Therapeutics

Latest Innovations

In vivo Active Inhibitors of FOXM1 for the Treatment of Breast Cancer

Triple Negative Breast Cancer (TNBC) constitutes about 10-20% of all diagnosed breast cancers and is known to be more aggressive and difficult to treat. TNBC lacks the...

Novel Endocannabinoid Therapeutics

Therapeutic endocannabinoid derivatives showing an increased half-life and enhanced anti-migratory properties. These compounds retain the anti-inflammatory, anti-cancerous...

Dearomative carboamination and its application in synthesis of anticancer agents

New synthesis method for isocarbostyril alkaloids based on dearomative carboamination of the benzene ring. This is the shortest and most efficient method known to date,...

Converting Gram-Positive Antibiotics to Gram-Negative Bacteria

Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and...

Isocarbostyril Alkaloids and Functionalization Thereof

Dr. Sarlah from the University of Illinois has synthesized novel analogs and isotopologs of the anticancer isocarbostyril alkaloids...

An Epitope- and Structure-based Shigella MEFA (multiepitope fusion antigen) Protein Induces Broad Antibody Responses against Shigella spp

Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by...

An Epitope and Structure-based Shigella MEFA (multiepitope fusion antigen) Protein Induces Broad Antibody Responses Against Shigella spp

Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by...

Fusidic Acid Derivatives with New Antibacterial Activity

Dr. Paul Hergenrother fhas developed a new series of broad spectrum fusidic acid derivatives. Designed using two distinct methodologies, these fusidic acid derivatives...

Split Prime Editing Platforms

Dr. Pablo Perez-Pinera has developed a method to divide prime editing tools into smaller components that are small enough to be delivered in adeno-associated viruses, an...

A Multivalent Cholera Multiepitope Fusion Antigen (MEFA) and Application for Development of Effective Vaccines for Cholera

 

Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against cholera. Cholera is an acute, diarrheal illness caused...

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