Therapeutics

Latest Innovations

HIV-1 Vaccine Immunogens

Dr. Procko from the University of Illinois at Urbana-Champaign has developed a novel set of HIV-1 immunogens for use as a HIV-1 vaccine. If effective these immunogens will...

In vivo Active Inhibitors of FOXM1 for the Treatment of Breast Cancer

Triple Negative Breast Cancer (TNBC) constitutes about 10-20% of all diagnosed breast cancers and is known to be more aggressive and difficult to treat. TNBC lacks the...

Novel Class of Anti-estrogen Drugs for the Treatment of Breast Cancer

Many estrogen receptor α (ERα)-positive breast cancers often develop resistance to endocrine therapy due to mutations in ERs. These mutations are associated with shorter...

Novel Endocannabinoid Therapeutics

Therapeutic endocannabinoid derivatives showing an increased half-life and enhanced anti-migratory properties. These compounds retain the anti-inflammatory, anti-cancerous...

Dearomative carboamination and its application in synthesis of anticancer agents

New synthesis method for isocarbostyril alkaloids based on dearomative carboamination of the benzene ring. This is the shortest and most efficient method known to date,...

Novel Estrogren Receptor β (ERβ) Drugs for the Treatment of Endometriosis

Endometriosis is the growth of endometrial lesions outside of the uterus – these lesions are adherent on various organs in the peritoneum, including the ovaries. It is a...

Novel Toll-like Receptor Inhibitors for the Treatment of Inflammatory Diseases

Toll-like receptors (TLRs) have been shown to play a vital role in the pathogenesis of many diseases, including inflammatory diseases. Exaggerated or prolonged TLR...

Converting Gram-Positive Antibiotics to Gram-Negative Bacteria

Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and...

Isocarbostyril Alkaloids and Functionalization Thereof

Dr. Sarlah from the University of Illinois has synthesized novel analogs and isotopologs of the anticancer isocarbostyril alkaloids...

An Epitope- and Structure-based Shigella MEFA (multiepitope fusion antigen) Protein Induces Broad Antibody Responses against Shigella spp

Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by...

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