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Pulmonary

Latest Innovations
Preparation of Degradable Silica-Drug Conjugated Nanoparticle with Monodisperse Particle Sizes The invention provides a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to... Read More The invention provides a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles.
Bioresorbable Silicon Electronics for Neural Sensing Dr. John Rogers from the University of Illinois at Urbana-Champaign has developed bioresorbable silicon electronics that can be used for real-time sensing of neural... Read More Dr. John Rogers from the University of Illinois at Urbana-Champaign has developed bioresorbable silicon electronics that can be used for real-time sensing of neural electrical activity. This invention could prevent follow-up neural surgeries, and has potentials for long-term monitoring of patients. 2015-158 Photo for Web.png
Quantum Dots with Thin Coatings that Allow for Efficient Bioconjugation Dr. Andrew Smith from the University of Illinois has developed new quantum dots with a multidentate polymer coating that minimizes size while maintaining stability and... Read More Dr. Andrew Smith from the University of Illinois has developed new quantum dots with a multidentate polymer coating that minimizes size while maintaining stability and improving efficiency of conjugation. Quantum dots are promising agents for cellular and molecular imaging, but their bulky organic coatings have limited their use in cells. Dr. Smith's quantum dots are small, stable, and can be conjugated to targeting molecules and purified easily.
Algorithm Modified Deoxynybomycin for the Treatment of Gram-Negative Bacteria Dr. Hergenrother from the University of IL has developed a novel antibiotic that is effective against certain antibiotic-resistant gram-negative bacteria. His powerful... Read More Dr. Hergenrother from the University of IL has developed a novel antibiotic that is effective against certain antibiotic-resistant gram-negative bacteria. His powerful predictive algorithm determines accumulation of molecules in Gram-negative bacteria and enables conversion of known Gram-positive only antibiotics into novel compounds with Gram-negative potency.
A Pro-Apoptotic Microbial Community Network Enriched in the Tissue of IPF and Lung Cancer Patients Dr. Isaac Cann from the University of Illinois has identified biomarkers and therapeutic strategy for treatment of... Read More Dr. Isaac Cann from the University of Illinois has identified biomarkers and therapeutic strategy for treatment of idiopathic pulmonary fibrosis (IPF) and lung cancer. This strategy has the potential to dramatically improve the lives of millions patients throughout the world. It is the first know effective treatment route for IPF. The therapeutic strategy is based on the discovery of link between microbial community remodeling and IPF. Furthermore, the lung microbial community can induce excessive apoptosis of alveolar lining epithelial cells leading to lung carcinogenesis. Benefit • Treatment strategies including broad spectrum antibiotics may be effective for treating IPF and preventing lung cancer