A method for imaging a brain of a subject includes providing a cognitive task for the subject or measuring resting state blood flow without a cognitive task, applying a saturation pulse sequence to saturate a slice within an imaging volume in the subject, and applying an imaging pulse sequence to acquire data from the imaging volume.
A saturated image is acquired shortly after termination of the saturation pulse sequence and a non-saturation image is acquired after spins flowing through the saturated slice have recovered. The saturation image and the non-saturation image are subtracted to generate a blood velocity or perfusion enhanced difference image indicating portions of the brain active during the cognitive task.
When measuring resting state blood flow without a cognitive task, the method includes acquiring a calibration scan and performing a quantitative evaluation of the blood velocity perpendicular to the saturated slice.
Dr. John Rogers from the University of Illinois at Urbana-Champaign has developed bioresorbable silicon electronics that can be used for real-time sensing of neural electrical activity. This invention could prevent follow-up neural surgeries, and has potentials for long-term monitoring of patients.
Dr. Andrew Smith from the University of Illinois has developed new quantum dots with a multidentate polymer coating that minimizes size while maintaining stability and improving efficiency of conjugation. Quantum dots are promising agents for cellular and molecular imaging, but their bulky organic coatings have limited their use in cells. Dr. Smith's quantum dots are small, stable, and can be conjugated to targeting molecules and purified easily.
Dr. Hergenrother from the University of IL has developed a novel antibiotic that is effective against certain antibiotic-resistant gram-negative bacteria. His powerful predictive algorithm determines accumulation of molecules in Gram-negative bacteria and enables conversion of known Gram-positive only antibiotics into novel compounds with Gram-negative potency.