Isocarbostyril Alkaloids and Functionalization Thereof

Dr. Sarlah from the University of Illinois has synthesized novel analogs and isotopologs of the anticancer isocarbostyril alkaloids lycoricidine and narciclasine. Currently, isocarbostyril alkaloids are low in natural abundance and have poor aqueous solubility. These new synthetic compounds exhibit improved metabolic activity, stability, and/or aqueous solubility. 
Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene. Bingham, et al. Dec 6, 2018.