Therapeutics

Latest Innovations

Enhancement of Immune Response to Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine by Interferon Alpha

 

Porcine reproductive and respiratory syndrome (PRRS) is a major problem for hog farmers worldwide. PRRS is caused by a virus which leads to reproductive failure in...

Therapeutic Scheme for Human Basigin

 

Cancer researchers are focusing their efforts on identifying central pathways that trigger or enhance the invasiveness of tumor cells. One such target is EMMPRIN (...

Biosynthesis of Lantibiotics: In vitro semi-synthetic production methods for generation of industrial antibiotic, Lacticin 481

 

This invention allows the engineering of semi-synthetic lantibiotics to a much larger extent than using typically practiced in vivo methods. The method is the...

Gene Cluster Capable of Enabling the Biosynthesis of the Antimicrobial Compound, Rhizocticin In Bacillus subtilis

 

Phosphonic and phosphinic acids are bioreactive compounds that have been used as antibiotics, antifungal agents, antimalarial drugs, and herbicides. Rhizocticins...

Therapeutic Agents for Treatment of Myotonic Dystrophy

 

Dr. Zimmerman's lab has developed a series of bioactive compounds for the treatment of myotonic dystrophy. The compounds disrupt the MBNL-(CUG) foci in vivo and...

Pharmaceutical Compounds and Pathways from Actinobacteria

 

Dr. Metcalf and Dr. van der Donk from the University of Illinois have discovered 12 novel phosphonate natural products as well as the genes responsible for the...

Compounds That Selectively Induce Cancerous Cell Death in the G1 Phase of the Cell Cycle

 

Malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients is 6 months. This coupled with the...

Compounds for the Treatment of Fluoquinolone resistant infections

 

Researchers from the University of Illinois have synthesized a variety of compounds with strong activity toward fluoroquinolone resistant bacteria. These compounds...

New Drugs for Malarial and Bacterial Infections

 

New anti-infectives are required now more than ever as resistance to existing drugs increases in prevalence. Enzymes unique to bacteria or parasites are potential...

Supramolecular Assembly for Non-Viral Gene Delivery

 

Gene therapy is an approach for human disease treatment. This is done by inserting nucleic acids into cells to produce proteins, fix or replace damaged genes, and...

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