Dr. Pablo Perez-Pinera from the University of Illinois has developed a multiplexable and universal nuclease-assisted vector integration system for rapid generation of gene knock outs using selection that does not require customized targeting vectors, thereby minimizing the cost and time frame needed for gene editing. Importantly, this system is capable of remodeling native mammalian genomes through integration of DNA, up to 50 kb, enabling rapid generation and screening of multigene knockouts from a single transfection. Furthermore, this method facilitates activation of genes by introduction of specific promoters that allows for genomic scale activation screens.
Benefits
• Minimizes cost and time for gene editing • Multigene knockouts can be rapidly generated • Facile integration of large constructs up to 50 kb • Introduces speci c promoters for genomic scale activation screens
Profs. Hyungsoo Choi and Kevin Kim have developed a hydrogel nanoparticle carrier comprising gelatin covalently crosslinked with cyclodextrin, which has a longer drug...
Profs. Hyungsoo Choi and Kevin Kim have developed a hydrogel nanoparticle carrier comprising gelatin covalently crosslinked with cyclodextrin, which has a longer drug release profile than other carriers. The invented nano/micro carriers allows delivery of therapeutic and/or diagnostic agents that have low aqueous solubility. These hydrophobic molecules are confined inside hydrophobic pockets, and are released as polymer matrix degrades.
Application
This technology is used for delivering hydrophobic drugs in aqueous environments in the body.
Benefit
This invention boasts a longer release profile and allows drugs to be released over a longer period of time due to additional crosslinking between gelatin and cyclodextrin.
Dr. Kong from the University of IL has developed microparticles that create fibrin gels with desirable properties for wound healing products, drug delivery, and...
Dr. Kong from the University of IL has developed microparticles that create fibrin gels with desirable properties for wound healing products, drug delivery, and diagnostic tools. When blood clots it forms fibrin gel networks to close wounds temporarily for more permanent healing to take place. A significant problem with artificially-made fibrin gel networks is that they can be difficult to tune to attain desirable gelation rate and rigidity. The microparticles developed by Dr. Kong solve this problem by releasing thrombin in response to H2O2 to make gels with tunable, desirable properties.
Benefits
Encapsulating thrombin and MnO2 nanosheets allows for decoupling of gelation rate and gel rigidity.
Applications
This technology may be used for nano- or microparticles for drug delivery, biological gels for biomedical applications, or bleeding control/wound management.
