An innovative, cost-effective method for making and integrating fluidic microchannels. This method for ultra-rapid prototyping of microfluidic systems requiring...
An innovative, cost-effective method for making and integrating fluidic microchannels. This method for ultra-rapid prototyping of microfluidic systems requiring fewer than 5 minutes from design to prototype uses liquid phase polymerization as an alternative to etching microchannels in silcone or glass.
The method consists of introducing liquid prepolymer into a plastic or glass cartridge, exposing the prepolymer to ultraviolet light through a mask to encourage photopolymerization and define channel geometry, removing the unpolymerized prepolymer, and rinsing the resulting microchannel.
The actuators used in this technology require nothing more than the chemicals surrounding them to monitor the chemistry, mimicking chemical balances as they are maintained in the human body. This new method is ideal for biological and medical applications requiring organic materials, no electronics or batteries, bioresponsiveness, and a single, uniform platform for processing. Potential applications include detection of biological and chemical agents, disease, and contaminants, and in vitro diagnostics and therapy devices. Other promising applications exist in the area of microelectromechanical systems (MEMS).
The invention greatly reduces the time and cost associated with the creation of microfluidics systems and requires no experience in microfabrication techniques, no cleanroom facilities, and no expensive equipment. Easy integration enables a manufacturing environment to readily incorporate "add-on" fluidics. This new technology allows ultra rapid prototyping and iterative design, affords immediate production of components, and simplifies complex systems
MEMS stages comprising a plurality of comb drive actuators provide micro and up to nano-positioning capability. Flexure hinges and folded springs that operably...
MEMS stages comprising a plurality of comb drive actuators provide micro and up to nano-positioning capability. Flexure hinges and folded springs that operably connect the actuator to a movable end stage provide independent motion from each of the actuators that minimizes unwanted off-axis displacement, particularly for three-dimensional movement of a cantilever. Also provided are methods for using and making MEMS stages. In an aspect, a process provides a unitary MEMS stage made from a silicon-on-insulator wafer that avoids any post-fabrication assembly steps.
Further provided are various devices that incorporate any of the stages disclosed herein, such as devices requiring accurate positioning systems in applications including scanning probe microscopy, E-jet printing, near-field optic sensing, cell probing and material characterization.
Dr. Seok Kim from the University of Illinois has developed a method to fabricate a silicon-based MEMS mirror and its elastomeric universal joint. This method,...
Dr. Seok Kim from the University of Illinois has developed a method to fabricate a silicon-based MEMS mirror and its elastomeric universal joint. This method, termed micro-masonry, can be extended to integrate elastomer and silicon components, thus enabling strong mechanical and electrical connections between two heterogeneous materials without causing the damage of elastomer. As a result, the fabricated device could exhibit 3D motion in a compact gimballess design.
Thermal sensitivity in piezoresistive sensors used in silicon microcantilevers makes them susceptible to unwanted signals such as temperature drift. In addition,...
Thermal sensitivity in piezoresistive sensors used in silicon microcantilevers makes them susceptible to unwanted signals such as temperature drift. In addition, when used in chemical sensing, current microcantilevers have difficulty testing femtogram (10-15) scale samples due to the effect of temperature variations on the mechanical signal. This invention is a microcantilever hotplate with both a resistive heater and temperature-compensated piezoresistive strain gauges that correct for the effect of temperature variations on the mechanical strain signal. This enables the ability to test samples in femtogram quantities allowing the preservation of highly valuable materials such as DNA samples or new drug compounds. In contrast, samples tested on the milligram scale prove to be costly since the samples are often discarded after testing.
Microcantilevers with integrated piezoresistive strain sensors are mainly used to replace optical (laser) deflection sensing thus reducing design complexity and cost. They may also be employed in various sensing applications such as gas flow sensing, acceleration sensing, microjet measurements and bio/chemical sensing. As bio/chemical sensors, piezoresistive microcantilevers are often prepared with a selective coating that is sensitive to a specific analyte. Analyte adsorption induces static deflection of the microcantilever by creating a surface stress, thus enabling embedded piezoresistors to measure analyte adsorption on the cantilever.
Microcantilevers with both resistive heaters and piezoresistors can also offer simultaneous heating and sensing. Two different cantilever designs with the same surface area have been designed with integrated heaters along the cantilever edges and a pair of piezoresistors for temperature-compensated strain gauges. The fabricated devices show successful integration of resistive heaters and piezoresistors. These microcantilever hotplates could enable simultaneous calorimetric and thermogravimeteric measurements by operating the heater and the piezoresistor pair together.
Thermomechanical data storage, biomorph actuation; nanoscale thermal analysis and manufacturing; material diagnostic characterization; calorimetry; and biochemical sensing.
The Intellipore technology is a membrane system and method for creating complex, three-dimensional microfluidic devices with improved interconnect functionality....
The Intellipore technology is a membrane system and method for creating complex, three-dimensional microfluidic devices with improved interconnect functionality.
Intellipores interconnects are intelligent pores that are voltage-gated and externally controllable. Comprised of nanopore membranes and microfluidic channels, this technology enables highly selective flow control and rapid, real-time, intelligent molecular transport in threedimensional microfluidic devices, enabling structures which are analogous to Very Large Scale Integration (VLSI) structures in microelectronics.
This technologys versatility creates the opportunity for these interconnects to be incorporated into many new devices, enabling a variety of new applications.
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This technology describes a fabrication method for multi-channel, multi-layered microfluidic devices, with numerous functional characteristics capable of...
This technology describes a fabrication method for multi-channel, multi-layered microfluidic devices, with numerous functional characteristics capable of integration into a lab-on-a-chip platform. The chip allows broader analytical capabilities in point-of-use microfluidic technology than previously possible, and it does so with exceeding strength and stability.
Fabrication of this chip is made possible by a transfer process of labile membranes and the development of a contact printing method for a thermally curable epoxy-based adhesive. This adhesive has bond strengths that prevent leakage, channel rupture and delamination to nearly 6atm. Channels on the chip - 100 m wide and 20 m deep - are contact printed without the adhesive entering the microchannel.
The chip is characterized in terms of resistivity measurements along the microfluidic channels, electroosmotic flow (EOF) measurements at differing pH levels and laser-induced-fluorescence (LIF) detection of green-fluorescent (GFP) plugs injected across the nanocapillary membrane and into a microfluidic channel. The resulting product is a mixed-polymer micro-nanofluidic multilayer chip, which has the electrical characteristics necessary for use in microanalytical systems.
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The ability to increase the functionality and complexity of micro/nanofluidic devices is currently limited by the capacity to accurately detect the position of...
The ability to increase the functionality and complexity of micro/nanofluidic devices is currently limited by the capacity to accurately detect the position of fluids within them. While an increased number of electrical sensors can improve detection capabilities, the presence of too many external electrical connections makes integration into the micro/nanofluidic network difficult and complicated. This invention is a method for connecting large arrays of electrical micro/nanofluidic sensors to external monitoring equipment, while using only a limited number of leads.
Sensors consisting of small electrical components (resistors, capacitors, or conduction gaps) are placed within an interconnected fluidic network and are addressed using a multiplexing approach that allows an array of m*n sensors to be supported by only m+n+1 electrical contacts. The multiplexing relies on the fact that each sensing element is connected to two electrical leads, and each electrical lead is connected to multiple sensing elements. This is a new structure for the purpose of sensing in massively parallel fashion (electrical sensor arrays) while reducing the external connections necessary to address each individual sensor element in the field of lab-on-a-chip (LOC) technology. Large arrays of electrical sensors that can be integrated in micro/nanofluidic networks can be controlled and addressed by a limited number of electrical leads that connect to low end electronic controls.
Dr. Xiuling Li from the University of Illinois at Urbana-Champaign has invented a helical antenna using her self-rolled-up membrane technology that is capable of terahertz...
Dr. Xiuling Li from the University of Illinois at Urbana-Champaign has invented a helical antenna using her self-rolled-up membrane technology that is capable of terahertz transmission and reception. This has the potential to overcome the "terahertz" gap that plagues communications and can greatly increase data transfer rates.
The power of EM wave will get attenuated as it travels through the air. Therefore, by the time it ends up getting picked up by the receiver, the power level usually is...
The power of EM wave will get attenuated as it travels through the air. Therefore, by the time it ends up getting picked up by the receiver, the power level usually is below the detection threshold, as processing of the attenuated signal occupies the majority of the front-end receiver and thus conumes large amounts of energy. Instead of amplification (power), the invention uses chirp conversion technique which takes a chunk of input wave and compresses all the energy into a small space.
Dr. Seok Kim from the University of Illinois at Urbana-Champaign has developed a versatile surface material that will serve as a general-purpose platform for fluid and...
Dr. Seok Kim from the University of Illinois at Urbana-Champaign has developed a versatile surface material that will serve as a general-purpose platform for fluid and light manipulations for micro and macroscale. Potential applications include: digital microfluidics, biomedical devices, virtual blinds, camouflage surfaces, and micromirror arrays. Compared to similar surfaces, this responsive surface consists of micropillars integrated with large area platelets, which increases the areal fraction of opaque regions on the surface and increases the tuning range of transmittance. It does not require heating to create a vapor layer, and allows the use of soft, ferromagnetic micropillars and offers a more efficient assembly process than prior works. Lastly, it allowed control over the final configuration of the platelets, either in-plane or out-of-plane configurations, for the very first time.