Research Tools & Reagents

Latest Innovations

CRISPR-SKIP System to Modulate Expression of Exons & Improve Cellular Delivery of DNA Editing Systems

Dr. Perez-Pinera has developed a new way to edit genes using CRISPR technology that promises to be safer and more efficient that existing technologies. His method uses...

Cooperative Chemoenzymatic Process for Dynamic Kinetic Resolution of Alkanes

Dr. Huimin Zhao from the University of IL has developed a new method for dynamic kinetic resolution of alkene reduction products. It involves a photocatalyst that...

End-Modified Double-Strand DNA Donors for Clone-Free & Selection-Free Gene Knock-In in Mammalian Cells Lines

Dr. Zhao from the University of IL has developed a rapid, cloning-free CRISPR/Cas9 based gene knock-in (KI) method that utilizes Cas9/gRNA ribonucleoprotein( Cas9 RNP)...

NitroxylFluor: A Thiol-Based Fluorescent Probe for Detection of HNO in Living Cells

Dr. Chan has developed a novel fluorescent probe, NitroxylFluor, for the detection of HNO in living cells. This fluorescent probe is highly selective for HNO, is less...

A Highly Selective Fluorescent Probe for Detection of Cancer Stem Cells via Aldehyde Dehydrogenase 1A1 Activity

Dr. Chan from the University of IL has developed a highly selective fluorescent probe for cancer stem cells (CSCs) detection. This cell-permeable fluorescent probe is...

Chemoselective Methylene Hydroxylation in Aromatic Molecules

Dr. White from the University of IL has developed a small molecule catalyst which enables the chemoselective methylene hydroxylation in aromatic systems. This...

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Dr. Cheng from the University of IL has developed a method which enables the polypeptide synthesis using non-purified N-carboxyanhydrides (...

Extrapolative Prediction of Enantioselectivity Enabled by Computer-Driven Workflow, New Molecule Representations and Machine Learning

Dr. Denmark from the University of IL has developed a computer-assisted workflow for catalyst design and reaction outcome prediction. This...

Novel Compounds that Induce Ferroptotic Cell Death

Dr. Hergenrother from the University of IL has synthesized 29 compounds derived from natural product pleuromutilin. Ferroptocide from the...

CoxFluor™: An activity-based Fluorescent Probe for Cyclooxygen-ase-2 (COX2)

Dr. Jefferson Chan from the University of IL has developed CoxFluor™, the first “turn on”, isoform specific, fluorescent probe used to detect and image COX-2 activity in...

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