Novel Compounds that Induce Ferroptotic Cell Death

Dr. Hergenrother from the University of IL has synthesized 29 compounds derived from natural product pleuromutilin. Ferroptocide from the collection was identified as a ferroptosis inducer. Unlike commonly used inducers, ferroptocide induces ferroptosis in a novel mechanism. It is not only a powerful research tool toward better understanding of Ferroptosis mechanism, but also potential drug for cancer treatment.