Professor Jie Chen has developed a mouse myoblast cell line whose mTOR pathway is insensitive to the presence of rapamycin. This invention is useful for studying related biochemical pathways and the drivers for skeletal myogenesis.
Publications:
The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. Erbay, Chen. J. Biol. Chem. 2001.
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. Erbay, Park, Nuzzi, Schoenherr, Chen. J. Cell Biol. 2003.