Professor Jie Chen has developed a mouse myoblast cell line whose mTOR pathway is insensitive to the presence of rapamycin. This invention is useful for studying related biochemical pathways and the drivers for skeletal myogenesis.
The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. Erbay, Chen. J. Biol. Chem. 2001.
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. Erbay, Park, Nuzzi, Schoenherr, Chen. J. Cell Biol. 2003.