Dr. Hsiao-Wecksler from the University of IL has developed a method to evaluate muscle tone and joint movement through wearable hardware that quantifies muscle tone and...
Dr. Hsiao-Wecksler from the University of IL has developed a method to evaluate muscle tone and joint movement through wearable hardware that quantifies muscle tone and joint movement, a classification algorithm to identify abnormalities, and a software application to store history and patient data. This technology provides an objective, quantitative measure of muscle tone (spasticity & rigidity) and strength that is portable and can be used for muscles of upper and lower limbs.
This technology also reduces variability in clinical measurements, especially for the purpose of training clinicians. It improves the accuracy of measurements, which are important to evaluate efficacy of treatments.
Dr. Pengfei Song from the University of Illinois and his collaborators at the Texas A&M University developed a novel high volume-rate 3D ultrasound imaging method and a device based on Fast...
Dr. Pengfei Song from the University of Illinois and his collaborators at the Texas A&M University developed a novel high volume-rate 3D ultrasound imaging method and a device based on Fast Acoustic Steering via Tilting Electromechanical Reflectors (FASTER). This technology addresses challenges of conventional 3D ultrasound imaging like high cost and low volume scan rate. FASTER is capable of high volume rate (up to 500 Hz) large field-of-view 3D imaging with conventional 1D transducers.
Dr. Pengfei Song has developed methods of real-time SR-UMI. Current SR-UMI requires hours of data post-processing, making it impractical for clinical, diagnostic...
Dr. Pengfei Song has developed methods of real-time SR-UMI. Current SR-UMI requires hours of data post-processing, making it impractical for clinical, diagnostic applications. Implementing advances in deep learning and parallel computing, Dr. Song's team was able to realize real-time microbubble signal extraction, separation, localization, tracking, and quantitative analysis and display. This technology has a wide range of clinical applications including but not limited to the diagnosis and characterization of many disorders including cancer, cardiovascular disease, and neurological diseases.
Professor Jie Chen has developed a mouse myoblast cell line whose mTOR pathway is insensitive to the presence of rapamycin. This invention is useful for studying related...
Professor Jie Chen has developed a mouse myoblast cell line whose mTOR pathway is insensitive to the presence of rapamycin. This invention is useful for studying related biochemical pathways and the drivers for skeletal myogenesis.
Publications:
The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. Erbay, Chen. J. Biol. Chem. 2001.
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. Erbay, Park, Nuzzi, Schoenherr, Chen. J. Cell Biol. 2003.
Researchers from the University of Illinois have developed a highly sensitive, graphene field effect transistor (gFET) that can detect DNA in samples. This technology uses...
Researchers from the University of Illinois have developed a highly sensitive, graphene field effect transistor (gFET) that can detect DNA in samples. This technology uses Loop-Mediated Isothermal Amplification (LAMP) and crumpled graphene in order to detect the presence of a target segment of DNA within a provided sample. By using crumpled graphene, gFET, and LAMP Dr. Ganguli's technology is able rapidly detect pathogens using entirely electronic means bringing diagnostics directly to point of care medical practice, all while being less expensive, more sensitive, and quicker than other traditional, gold-standard pathogen diagnostics methods. This technology is even able to detect molecular concentrations down to 8 zeptomolar.
Publication: Ganguli, A., Faramarzi, V., Mostafa, A., Hwang, M. T., You, S., & Bashir, R. (2020). High Sensitivity Graphene Field Effect Transistor-Based Detection of DNA Amplification. Advanced Functional Materials, 30(28), [2001031]. https://doi.org/10.1002/adfm.202001031
Professor Beth Stadtmueller and Sonya Kumar Bharathkar have created a chimeric secretory immunoglobulin A (cSIgA) with a modified secretory component (SC) that can be used...
Professor Beth Stadtmueller and Sonya Kumar Bharathkar have created a chimeric secretory immunoglobulin A (cSIgA) with a modified secretory component (SC) that can be used in therapeutic treatment. The bispecific cSIgA can bind its target antigen and additional ligands by an engineered SC portion, such as toxins or surface antigens. This can be applied to treatment for mucosal infections such as Clostridium difficile.
Researchers from the University of Illinois Urbana-Champaign have developed a non-invasive method for the early detection of human papillomavirus (HPV)-positive and -...
Researchers from the University of Illinois Urbana-Champaign have developed a non-invasive method for the early detection of human papillomavirus (HPV)-positive and -negative head and neck cancer using saliva samples. This method has potential research and clinical applications including diagnosis of HPV-positive and -negative head-and-neck cancer. The approach detects several genes characteristic of each type of cancer HNSCC that are commonly detected in head-and-neck cancer.
Applications: Diagnosis of HPV-positive and -negative head-and-neck cancer; research applications
Benefits:
Non-invasive as it only requires saliva from patient
Saliva-based screening is quick (i.e., hours) and easy as it uses common laboratory equipment
Head-and-neck screening can be completed more than the recommendation of once a year because it is low in cost, fast, and non-invasive.
Radiological clips, or markers, are inserted at the time of biopsy to mark tumor locations, lesions and lymph nodes for consistent identification over time and multiple...
Radiological clips, or markers, are inserted at the time of biopsy to mark tumor locations, lesions and lymph nodes for consistent identification over time and multiple treatments. Prof. Michael Oelze has developed a new type of radiological clip that have a unique ultrasonic signal, acting like both a beacon and a barcode. This technology can be particularly helpful to mark multiple areas that are close together.
