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Diagnostic Hardware/Software/Medical Devices

Latest Innovations
EMCCD Scintillation Camera for Low Energy X and Gamma Ray Imaging A system that incorporates teachings of the present disclosure may include, for example, an ionizing radiation sensor having a first scintillator for generating... Read More A system that incorporates teachings of the present disclosure may include, for example, an ionizing radiation sensor having a first scintillator for generating photons from incoming ionizing radiation, an imaging intensifier for amplifying the photons, and an electron-multiplying charge-coupled device (EMCCD) coupled to the imaging intensifier for sensing the amplified photons generated by the imaging intensifier.
Group Refractive Index Reconstruction with Broadband Interferometric Confocal Microscopy A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical... Read More A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical aperture microscope embedded into an interferometer and a spectrometric means, whereby spectral interferograms are analyzed to compute optical path delay of the beam traversing the sample as the sample is translated through the focus of an interrogating light beam. A determination of group refractive index may serve to disambiguate phase ambiguity in a measurement of refractive index at a specified wavelength. Spatial resolution of object characterization in three dimensions is achieved by imaging the object from multiple viewpoints. Applicable to a variety of industries, this novel method measures Group Refractive Indices of biological tissues at the micron scale and can be applied to several optical imaging techniques, such as Optical Coherence Tomography and Confocal Microscopy. Although the method can be used for non-medical applications, its most beneficial application is in the diagnosis of cancerous cells. It allows for quickly measuring cells' organelles to indentify cancerous properties. Since this method does not require refraction, a larger variety of biological samples can be examined. Hardware is readily available for the application of this method, and the method can be applied to any optical imaging technique due to its universal math.
A Non-Invasive Blood Viscosity Measurement through Pulse Oximetry A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation... Read More A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation level in a liquid, a magnetic source coupled to the pulse oximeter sensor, and a controller to control the pulse oximeter sensor and the magnetic source, and to measure a mechanical effect on the liquid responsive to the magnetic source applying a magnetic field to the liquid.
Ultrasonic Biopsy Needle Shear Wave Imaging An apparatus and method for estimating and imaging mechanical properties of biological tissues. The apparatus includes one or two ultrasound emitting devices (... Read More An apparatus and method for estimating and imaging mechanical properties of biological tissues. The apparatus includes one or two ultrasound emitting devices (transducers) that first apply an acoustic radiation force to vibrationally displace a sphere embedded in the medium. Alternatively, a biopsy needle may be inserted into the medium and vibrated along its axis to generate shear waves. During and after vibration, ultrasound is again applied to image shear waves in the medium that propogate from the vibrating sphere or needle. By measuring the local wavelength of the shear waves, the shear modulus and viscous coefficient of the medium surrounding the vibrating element are estimated.
Auto-Calibrating Parallel MRI Technique with Distortion-Optimal Image Construction This invention provides a new computational method for the formulation of magnetic resonance (MR) images to 1) reduce the scan time and complexity and 2) improve... Read More This invention provides a new computational method for the formulation of magnetic resonance (MR) images to 1) reduce the scan time and complexity and 2) improve upon existing MRI methods. This is all accomplished while maintaining the integrity and functionality of other MRI methods. This invention describes the development of a computational method for the formulation of magnetic resonance (MR) images. It achieves this by utilizing data acquired by multiple receiver channels available on standard MRI scanners to 1) automatically identify the receiver characteristics without the need for additional data acquisition, 2) using the identification results to enable high quality imaging with fewer data samples than current methods and 3) improving upon the existing parallel MRI methods. This technology addresses two of the key issues/challenges (faster data retrieval and artifact free images) that MRI industry currently faces. Applications Neurological Musculoskeletal Cardiovascular Oncological Benefits Reduced scan time Increased set of clinical applications Reduced complexity Better, high quality MR images (Artifact-Free Imaging) Software can be uploaded to existing machines
Computed Pathology: Stain-Free Computational Imaging Researchers from the University of Illinois have developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological... Read More Researchers from the University of Illinois have developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological samples without the use of any stains or dyes. The tissue is computationally recreated as if it were stained and imaged in diagnosis of biological samples. This method improves the cost and efficiency by avoiding expense and lessening the time required to complete multiple stains. Also, it improves the overall consistency of the staining process.
Highly Accelerated Image Reconstruction in Medical Imaging Researchers from the University of Illinois have developed a state of the art method that can reconstruct images in better quality, in less time, with fewer scans... Read More Researchers from the University of Illinois have developed a state of the art method that can reconstruct images in better quality, in less time, with fewer scans. They leveraged sparse characteristic of the image data and produced a two step algorithm that learns the patches of the image from the data and subsequently decreases elements in each patch.
Improved Magnetic Resonance Elastography Researchers at the University of Illinois have developed sequences that control the process of magnetic resonance elastography (MRE) data acquisition. ... Read More Researchers at the University of Illinois have developed sequences that control the process of magnetic resonance elastography (MRE) data acquisition. Capturing MRE data using single shot, echo planar imaging can quickly and non-invasively measure the stiffness of tissue. The subsequent image processing steps do not require off line computing, which improves the convenience of MRE in a clinical setting.
System and Method for Designing Multi-Channel RF Pulses for MR Imaging A system and method for designing RF pulses for multi-channel and/or multi-dimensional spatially-selective applications using a linear approximation. Embodiments... Read More A system and method for designing RF pulses for multi-channel and/or multi-dimensional spatially-selective applications using a linear approximation. Embodiments of the system and method may use a generalized linear-class large tip angle approximation to design RF pulses for multi-channel and parallel transmission. Further, some of these approximations allow for the design of arbitrarily large flip angles, irregularly-shaped flip angle profiles, or arbitrary initial magnetization values. Embodiments of the system and method may also provide for the design of k-space trajectories which aid in maintaining assumptions of the various linear class approximations.
X-Ray Fluorescence Computed Tomography with an Emission Tomography System A system that incorporates teachings of the present disclosure may include, for example, an apparatus having a collimator having at least one aperture and a... Read More A system that incorporates teachings of the present disclosure may include, for example, an apparatus having a collimator having at least one aperture and a fluorescence detector. The collimator can be positioned next to a compound. The compound can emit fluorescence X-rays when impacted by an X-ray beam generated by an X-ray source. The collimator can absorb at least a first portion of the fluorescence X-rays emitted by the compound and release at least a second portion of the fluorescence X-rays at the at least one aperture. The second portion of the fluorescence X-rays released by the at least one aperture have known directional information based on a position of the collimator. The fluorescence detector can detect the second portion of the fluorescence X-rays released by the at least one aperture. A three-dimensional (3-D) rendering of an elemental distribution of the compound can be determined from the fluorescence X-rays detected and the directional information.

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