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A System for High-Fidelity Multiplex Detection of Biomarkers Dr. Aksimentiev from the University of Illinois at Urbana-Champaign, with colleagues at Northeastern and University of North Carolina,... Read More Dr. Aksimentiev from the University of Illinois at Urbana-Champaign, with colleagues at Northeastern and University of North Carolina, has developed multiplex detection platform for general biomarker sensing. This platform uses nanopore-based fingerprinting of nucleic acid nanoparticles to detect the presence of biomarkers. Using a single nanoparticle kit, this invention makes it possible to detect a variety of biomarkers and, thus, diagnose a variety of health conditions. The primary application for this biomarker sensing platform is in the diagnosis of health conditions (e.g., cancer). Additional applications include encryption for homeland security and biodefense.
Novel Toll-Like Receptor Inhibitors for Treatment of Inflammatory Disease Dr. Katzenellenbogen from the University of Illinois at Urbana-Champaign has developed a novel class of inhibitors capable of inhibiting Toll-like Receptor signaling.... Read More Dr. Katzenellenbogen from the University of Illinois at Urbana-Champaign has developed a novel class of inhibitors capable of inhibiting Toll-like Receptor signaling. These compounds will allow treatment of inflammatory diseases such as sepsis. Currently there are no TLR inhibitors on the market and this novel set of compounds show higher affinity than currently published compounds. In addition to high specificity for TLRs these compounds are also able to be derivatized for specificity to specific classes of TLRs.
Novel Endocannabinoid Therapeutics Dr. Aditi Das from the University of Illinois at Urbana-Champaign has developed a novel set of therapeutic endocannabinoid derivatives.... Read More Dr. Aditi Das from the University of Illinois at Urbana-Champaign has developed a novel set of therapeutic endocannabinoid derivatives. These derivatives retain the anti-inflammatory, anti-cancerous, anti-angiogenic, and anti-platelet aggregatory properties while having an increased half life. As these compounds are based off endogenous endocannabinoids it is predicted side-effects will be miminal. Importantly these derivatives show enhanced anti-migratory properties compared to the endogenous compound suggesting they will act as potent drugs.
Novel Endocannabinoid Therapeutics Therapeutic endocannabinoid derivatives showing an increased half-life and enhanced anti-migratory properties. These compounds retain the anti-inflammatory, anti-cancerous... Read More Therapeutic endocannabinoid derivatives showing an increased half-life and enhanced anti-migratory properties. These compounds retain the anti-inflammatory, anti-cancerous, anti-angiogenic, and anti-platelet aggregatory properties and are predicted to have minimal side-effects.
Dearomative carboamination and its application in synthesis of anticancer agents New synthesis method for isocarbostyril alkaloids based on dearomative carboamination of the benzene ring. This is the shortest and most efficient method known to date,... Read More New synthesis method for isocarbostyril alkaloids based on dearomative carboamination of the benzene ring. This is the shortest and most efficient method known to date, enabling further synthesis of novel derivatives with improved metabolic activity, stability, and aqueous solubility.
Large Scale Parallel DNA Detection by 2D Solid-state Multi-pore Systems A scalable device design of a dense array of multiple 2D nanopores made from nanoscale semiconductor materials to simultaneously detect multiple DNA strands and identify... Read More A scalable device design of a dense array of multiple 2D nanopores made from nanoscale semiconductor materials to simultaneously detect multiple DNA strands and identify translocations of many biomolecules in a massively parallel detection scheme. The technology is based on the variation of the transverse sheet current across each membrane. The electronic sensing across the nanopore membrane offers a higher detection resolution compared to ionic current blocking technique in a multi-pore setup, irrespective of the irregularities that occur while fabricating the nanopores in a 2D membrane.
Solution Coating and Printing of Pharmaceutical Nanothin Films and Multilayer Nanocomposites A meniscus-guided solution coating technique to produce pharmaceutical nanothin films. This is a new way to manufacture personalized multilayer combination drugs, which... Read More A meniscus-guided solution coating technique to produce pharmaceutical nanothin films. This is a new way to manufacture personalized multilayer combination drugs, which can be beneficial to types of cancer where mono-chemotherapy is ineffective. This new technology enables a uniform deposition of thin films down to a few nm in thickness, easy alternation of the film morphology (modulation of dissolution rate) and polymorphism (control of bioavailability), and a layer-by-layer production of dosages comprised of multiple active pharmaceutical ingredients. The method is cost-competitive, scalable, and high-throughput.
Novel Toll-like Receptor Inhibitors for the Treatment of Inflammatory Diseases Toll-like receptors (TLRs) have been shown to play a vital role in the pathogenesis of many diseases, including inflammatory diseases. Exaggerated or prolonged TLR... Read More Toll-like receptors (TLRs) have been shown to play a vital role in the pathogenesis of many diseases, including inflammatory diseases. Exaggerated or prolonged TLR activation leads to pathological inflammation and other diseases. Despite the need, there are no small-molecule drugs clinically available against TLR pathways. This may be due to the significant signaling complexity of TLR signaling mechanisms. Dr. John Katzenellenbogen and a team of researchers have developed a novel class of inhibitors capable of inhibiting TLR signaling. These compounds have the potential to treat various inflammatory diseases.
Robotic Surgery with Haptic Feedback Researchers from University of Illinois have advanced the field of robotic surgery by introducing haptic feedback based on the 3D point cloud reconstruction technique. The... Read More Researchers from University of Illinois have advanced the field of robotic surgery by introducing haptic feedback based on the 3D point cloud reconstruction technique. The point cloud can be seen in the display and the doctor receives a feedback if the tip of the tool touches any unexpected region or with too great a force. The application has great potential since a small mistake can lead to death due to excessive bleeding.
Converting Gram-Positive Antibiotics to Gram-Negative Bacteria Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and... Read More Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and compound of matter are assisted by machine learning algorithm used for finding the characteristics of successful Gram-negative antibiotics. This invention offers wide-variety of Gram-negative antibiotic compounds for patients.