Skip to main content

All of These

Latest Innovations
Preparation of Degradable Silica-Drug Conjugated Nanoparticle with Monodisperse Particle Sizes The invention provides a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to... Read More The invention provides a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles.
Pharmaceutical Compounds and Pathways from Actinobacteria Dr. Metcalf and Dr. van der Donk from the University of Illinois have discovered 12 novel phosphonate natural products as well as the genes responsible for the... Read More Dr. Metcalf and Dr. van der Donk from the University of Illinois have discovered 12 novel phosphonate natural products as well as the genes responsible for the biosynthesis of hundreds of additional compounds of other natural product classes. Phosphonic and phosphinic acids represent an underexploited group of bioactive compounds with great promise for the treatment of human disease.
Enhanced Resolution for Biomedical Ultrasound Imaging Prof. Oelze from the University of Illinois has developed a novel technique of processing ultrasound images which will improve the spatial resolution by a factor... Read More Prof. Oelze from the University of Illinois has developed a novel technique of processing ultrasound images which will improve the spatial resolution by a factor of 6.9 (at least) over the diffraction limited approaches. It will also provide significant noise reduction.
Simultaneous Identification of Mechanical and Optical Properties of Single Viruses using a Single Device Professor Bahl from the University of Illinois at Urbana-Champaign has developed a device that can identify both optical and mechanical... Read More Professor Bahl from the University of Illinois at Urbana-Champaign has developed a device that can identify both optical and mechanical properties of single viruses with much higher throughput than current methods. This method takes us one step closer to identify the virus rather than just detect it. The rapid label-free identification of viruses can bring about a revolution in human health diagnostics and therapeutics.
Computational Improvements for Optical Coherence Tomography Dr. Boppart from the University of Illinois has developed new computational algorithms to improve Optical Coherence Tomography (OCT) imaging. This will provide... Read More Dr. Boppart from the University of Illinois has developed new computational algorithms to improve Optical Coherence Tomography (OCT) imaging. This will provide surgeons with a better view of cancerous tissue and allow improved treatment of numerous diseases.
Nano-Antennas light up to Sequence DNA Dr. Aksimentiev from the University of Illinois at Urbana-Champaign and researchers at TU Delft in The Netherlands have developed a plasmonic nanopore technology for DNA... Read More Dr. Aksimentiev from the University of Illinois at Urbana-Champaign and researchers at TU Delft in The Netherlands have developed a plasmonic nanopore technology for DNA sequencing. One of the hurdles facing current nanopore-based DNA sequencing technologies is the inability to control DNA speeds passing through the pore. The group has developed nano-antennas that can focus high intensity light on the nanopore to create a "hot-spot" to trap and slow down DNA movement, which can help read long lengths of DNA more efficiently.
Creating Super-Resolution Images using Standard Photobleaching and Blinking Movies Current super-resolution microscopy techniques require special laser setups and fluorescent molecules (such as PALM and STORM) that allow the fluorophores to be... Read More Current super-resolution microscopy techniques require special laser setups and fluorescent molecules (such as PALM and STORM) that allow the fluorophores to be turned on and off so that only a small number of fluorophores are turned on at any time. With the Super Shrimp image analysis algorithm, super-resolution images can be created from images with high densities of fluorophores. The invention creates microscopy images that have 5 or more times better resolution than standard microscopy images while using the standard microscopic set up available in most laboratories. It allows use of any fluorescent molecule (including quantum dots) that blinks or photobleaches to pick fluorophores out of the fluorescent background, and it can work with thousands of fluorophores in an image. This image analysis algorithm can localize quantized drops in fluorescence even with a background to create super-resolution images from standard photobleaching movies. It does not require special photo-switchable fluorophores (PALM, STORM) or fluorophores with long-lived dark states (dSTORM). The data acquisition is accomplished in minutes instead of hours and it can use standard laboratory microscopic set up with any fluorescent molecule. The algorithm processes a movie in which fluorescent molecules or particles are photobleaching or blinking and looks for individual photobleaching events that can be located with high resolution (i.e. the position of the fluorescent molecules). A composite image with resolution much higher than the original movie can then be generated. Noise is reduced by rejecting fluorophores that are poorly fit by a Gaussian and frames are averaged. Benefits The image analysis algorithm to create super-resolution images using standard photobleaching and blinking movies provides the following benefits: Uses standard laboratory equipment. Enables sub-cellular structure examination Can be used with any fluorescent molecule that can be detected by a CCD camera. It can use high labeling densities Fast data acquisition
Computed Pathology: Stain-Free Computational Imaging Researchers from the University of Illinois have developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological... Read More Researchers from the University of Illinois have developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological samples without the use of any stains or dyes. The tissue is computationally recreated as if it were stained and imaged in diagnosis of biological samples. This method improves the cost and efficiency by avoiding expense and lessening the time required to complete multiple stains. Also, it improves the overall consistency of the staining process.
Complex and Diverse Compounds from Abietic Acid Dr. Paul Hergenrother from the University of Illinois has created a diverse compound screening library from the synthetic scaffold abietic acid. Abietic acid... Read More Dr. Paul Hergenrother from the University of Illinois has created a diverse compound screening library from the synthetic scaffold abietic acid. Abietic acid is an abundant and widely available compound. Through manipulation of the ring system, the Hergenrother lab has constructed more than 91 novel and diverse compounds to be used in a high throughput drug screen. Dr. Hergenrother has received numerous honors for his achievements in chemistry and cancer research. The Hergenrother laboratory seeks to use small molecules to identify and validate novel targets for the treatment of intractable diseases, including cancer, degenerative disorders, and multi-drug resistant bacteria.
Miniaturized Walking Biological Machines Dr. Bashir has developed a walking biological machine. This "bio-bot" can move spontaneously, and may be useful for sensing, information processing, transport,... Read More Dr. Bashir has developed a walking biological machine. This "bio-bot" can move spontaneously, and may be useful for sensing, information processing, transport, protein expression and actuation applications.

Pages