Dr. Hergenrother from the University of IL has synthesized 29 compounds derived from natural product pleuromutilin. Ferroptocide from the collection was identified as a ferroptosis inducer. Unlike commonly used inducers, ferroptocide induces ferroptosis in a novel mechanism. It is not only a powerful research tool toward better understanding of Ferroptosis mechanism, but also potential drug for cancer treatment.
Dr. Jefferson Chan from the University of IL has developed CoxFluor™, the first “turn on”, isoform specific, fluorescent probe used to detect and image COX-2 activity in...
Dr. Jefferson Chan from the University of IL has developed CoxFluor™, the first “turn on”, isoform specific, fluorescent probe used to detect and image COX-2 activity in vivo and in vitro. The CoxFluor™ probe improves the quality of COX-2 assessments by providing more accurate and real-time measurements of enzyme activity and can be used as a basic science research tool/imaging probe for biological and pharmaceutical studies.
Application
Basic science research tool/imaging probe for biological and pharmaceutical studies
