Dr. Hergenrother from the University of IL has synthesized 29 compounds derived from natural product pleuromutilin. Ferroptocide from the collection was identified as a ferroptosis inducer. Unlike commonly used inducers, ferroptocide induces ferroptosis in a novel mechanism. It is not only a powerful research tool toward better understanding of Ferroptosis mechanism, but also potential drug for cancer treatment.
Dr. Jefferson Chan from the University of IL has developed CoxFluor™, the first “turn on”, isoform specific, fluorescent probe used to detect and image COX-2 activity in...
Dr. Jefferson Chan from the University of IL has developed CoxFluor™, the first “turn on”, isoform specific, fluorescent probe used to detect and image COX-2 activity in vivo and in vitro. The CoxFluor™ probe improves the quality of COX-2 assessments by providing more accurate and real-time measurements of enzyme activity and can be used as a basic science research tool/imaging probe for biological and pharmaceutical studies.
Application
Basic science research tool/imaging probe for biological and pharmaceutical studies
Dr. Pablo Perez-Pinera has developed a method to divide prime editing tools into smaller components that are small enough to be delivered in adeno-associated viruses, an...
Dr. Pablo Perez-Pinera has developed a method to divide prime editing tools into smaller components that are small enough to be delivered in adeno-associated viruses, an FDA-approved vehicle for therapeutic use. Prime editors have recently shown great promise as gene editing tools with greater specificity and fewer off-target effects than existing CRISPR-Cas based methods. This technology has potential as a research tool as well as a therapeutic strategy.
Professor Jie Chen has developed a mouse myoblast cell line whose mTOR pathway is insensitive to the presence of rapamycin. This invention is useful for studying related...
Professor Jie Chen has developed a mouse myoblast cell line whose mTOR pathway is insensitive to the presence of rapamycin. This invention is useful for studying related biochemical pathways and the drivers for skeletal myogenesis.
Publications:
The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. Erbay, Chen. J. Biol. Chem. 2001.
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. Erbay, Park, Nuzzi, Schoenherr, Chen. J. Cell Biol. 2003.
Dr. Hyunjoon Kong has developed an electrothermal manipulator for fragile, thin films. The device allows thin materials to be moved without comprising their integrity and...
Dr. Hyunjoon Kong has developed an electrothermal manipulator for fragile, thin films. The device allows thin materials to be moved without comprising their integrity and is a more versatile method than existing ones. It can be used in the transport of cell sheets and thin electronics. It can also be used in both wet and dry conditions. It may be used for biomedical tissues and cell sheets, as well as ultra-thin electronic materials.
Dr. Thomas Gaj has developed a novel prime editor based on a Staphylococcus aureus Cas9 ortholog. Furthermore, he has developed split intein versions of the prime editing...
Dr. Thomas Gaj has developed a novel prime editor based on a Staphylococcus aureus Cas9 ortholog. Furthermore, he has developed split intein versions of the prime editing tools that are small enough to be dual-delivered in adeno-associated viruses, an FDA-approved vehicle for therapeutic use. This invention has been shown to improve targeting capability of the prime editors by several fold. Prime editors have recently shown great promise as gene editing tools with greater specificity and fewer off-target effects than existing CRISPR-Cas based methods. This technology has potential as a research tool as well as a therapeutic strategy.
