Dr. Li from the University of IL has developed PEG gel and PDMS networks that have mechanophore’s embedded in them and has developed a method of using Ultrasound technique...
Dr. Li from the University of IL has developed PEG gel and PDMS networks that have mechanophore’s embedded in them and has developed a method of using Ultrasound technique to activate the mechanophores. The invention would be useful for non-invasive procedures and allow for stimulation of neurons by illuminating the mechanophore with ultrasound waves.
Dr. Abbaszadeh from the University of Illinois has invented a method and system for increasing radiation sensitivity in semiconductor detectors used in medical imaging...
Dr. Abbaszadeh from the University of Illinois has invented a method and system for increasing radiation sensitivity in semiconductor detectors used in medical imaging devices, such as Positron emission tomography (PET) scanners. Cadmium zinc telluride (CZT) is used in radiation detection medical applications. The cross- strip configuration of CZT detectors reduces the number of readout channels from n2 in pixelated electrode configuration to n. If there are multiple interaction photon events, multiple anodes and cathodes will be triggered at the same time and create ambiguity in determining the exact position of interaction. Generally, the multiple interaction events in cross-strip detectors are discarded. This invention will increase the sensitivity of semiconductor detectors by including these events. The sensitivity of the system is improved by nearly an order of magnitude.
Schematic of box-shaped CZT-based small animal PET system.
Dr. Hsiao-Wecksler from the University of IL has developed a method to evaluate muscle tone and joint movement through wearable hardware that quantifies muscle tone and...
Dr. Hsiao-Wecksler from the University of IL has developed a method to evaluate muscle tone and joint movement through wearable hardware that quantifies muscle tone and joint movement, a classification algorithm to identify abnormalities, and a software application to store history and patient data. This technology provides an objective, quantitative measure of muscle tone (spasticity & rigidity) and strength that is portable and can be used for muscles of upper and lower limbs.
This technology also reduces variability in clinical measurements, especially for the purpose of training clinicians. It improves the accuracy of measurements, which are important to evaluate efficacy of treatments.
Amyotrophic lateral sclerosis (ALS) is a fatal neurogenerative disorders that affect 5,000 people in the U.S. each year. Huntington’s disease (HD) is another progressive...
Amyotrophic lateral sclerosis (ALS) is a fatal neurogenerative disorders that affect 5,000 people in the U.S. each year. Huntington’s disease (HD) is another progressive and fatal neurogenerative disorder that affects nearly 30,000 people in the U.S. Both of these neurodegenerative disorders are associated with abnormal protein accumulation, such as SOD1 and HTT. CRISPR-Cas13 targets the genes of interest (i.e., SOD1 and HTT) and ultimately reduces the gene expression that are related to ALS and HD. Previous CRISPR technologies often use the Cas9 enzyme, which presents multiple problems with ease of delivery, size, and potential genomic damage to cells. Cas13 is smaller in size, making it easier to deliver. Furthermore, Cas13 targets the RNA—not the DNA, which means Cas13 downregulates gene expression without having to change the DNA sequence.
Prof. Yurii Vlasov and Christopher Kenji Brenden from the University of Illinois have designed an electrochemical biosensor capable of detecting small concentrations of...
Prof. Yurii Vlasov and Christopher Kenji Brenden from the University of Illinois have designed an electrochemical biosensor capable of detecting small concentrations of neurochemicals in vivo with high spatiotemporal resolution.
The probe design include a thin-layer design with microfluidic channels to decrease probe size and improve the voltage-current response from electroactive biomolecules. Electrodes are placed within the microfluidic channels of the cell to prevent degradation of electrode surfaces by immune responses and attack by biological agents.
Valve-free flow switching allows for in situ regeneration and calibration of the probe electrodes without removing the probe from the target biological tissue. This allows for longer measurements periods without experience large drift in electrochemical signals.
