Professor Beth Stadtmueller and Sonya Kumar Bharathkar have created a chimeric secretory immunoglobulin A (cSIgA) with a modified secretory component (SC) that can be used...
Professor Beth Stadtmueller and Sonya Kumar Bharathkar have created a chimeric secretory immunoglobulin A (cSIgA) with a modified secretory component (SC) that can be used in therapeutic treatment. The bispecific cSIgA can bind its target antigen and additional ligands by an engineered SC portion, such as toxins or surface antigens. This can be applied to treatment for mucosal infections such as Clostridium difficile.
RT-PCR RNA based approaches, the most popular method for SARS-CoV-2 detection, are limited by large numbers of consumables and reagents required, the need for well-...
RT-PCR RNA based approaches, the most popular method for SARS-CoV-2 detection, are limited by large numbers of consumables and reagents required, the need for well-optimized protocols, challenges with mutations, and RNA lingering after infectivity. Researchers at the University of Illinois, led by Dr. Aaron Timperman, have developed a protein-based rapid, reliable and inexpensive nanofluidic/microfluidic system to detect viral proteins with limits of detection at clinically relevant levels. The system receives a sample, purifies the virions, prepares the sample and sprays the sample directly into a mass spectrometry. This protein-based approach allows the collection of additional information such sequence mutations, modifications that affect protein function, and bound antibodies.
