Nanopore-based System for Molecule Sequencing

Dr. Aksimentiev has developed a new solid-state nanopore DNA sequencing method that affords superior control over DNA translocation. By creating custom-sized nanopores and exercising specifically designed microfluidic flow, this method allows for "flossing" of a DNA or RNA strand between nanopores. This allows for multiple reads and improved accuracy of sequencing strands. In comparison to existing platforms, this technology offers superior control over the passage of DNA through the nanopore and improves the accuracy of nanopore sequencing results. This technology can be integrated with most existing nanopore sequencing platforms. In addition to DNA, this technology has potential utility for characterizing other biopolymers, including proteins.