Multi-Functional Plasmon-Resonant Contrast Agents for Optical Coherence Tomography (OCT)


This portfolio of optical contrast agents and molecular detection technologies were developed to enhance the ability of optical coherence tomography (OCT) to non-invasively map molecules in living specimens and diagnose disease where it starts. OCT utilizes low-coherence interferometry to measure the intensity of reflected or backscattered light to form images with micrometer resolution, is readily integrated with existing optical instrumentation and has application across a wide range of biological, medical, surgical, and non-biological specialties.

This class of nanospheres and nanorods exhibit tunable plasmon resonances and can be engineered to specific sizes with strong absorption or scattering at select wavelengths - most notably the near-infrared range - for enhancing the sensitivity and scope of OCT.


  • Perform diagnostic and therapeutic functions
  • Capable of targeting specific cells and cell structures
  • Tunable optical properties
  • Variable resonance depending on particle orientation¬†