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Human Systems

Latest Innovations
Robotic Surgery with Haptic Feedback Researchers from University of Illinois have advanced the field of robotic surgery by introducing haptic feedback based on the 3D point cloud reconstruction technique. The... Read More Researchers from University of Illinois have advanced the field of robotic surgery by introducing haptic feedback based on the 3D point cloud reconstruction technique. The point cloud can be seen in the display and the doctor receives a feedback if the tip of the tool touches any unexpected region or with too great a force. The application has great potential since a small mistake can lead to death due to excessive bleeding.
Detection of Neurotransmitters via Interfacial pH Modulated Assisted Ion Transfer Dr. Shen from University of IL has developed an electrochemical method to directly detect neurotransmitters gamma-aminobutyric acid (GABA) and glutamate without... Read More Dr. Shen from University of IL has developed an electrochemical method to directly detect neurotransmitters gamma-aminobutyric acid (GABA) and glutamate without modification. In the detection, neurotransmitters are protonated thereby forming complexes with ionophores. This method is convenient and is able to monitor dynamic information of neurotransmitters. This method is compatible with both large instruments and benchtop unit.
Converting Gram-Positive Antibiotics to Gram-Negative Bacteria Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and... Read More Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and compound of matter are assisted by machine learning algorithm used for finding the characteristics of successful Gram-negative antibiotics. This invention offers wide-variety of Gram-negative antibiotic compounds for patients.
Characterizing Glioblastoma Heterogeneity via Single-cell Receptor Quantification Dr. Princess Imoukhuede from University of Illinois has developed a new quantitative receptor measurement approach for examining glioblastomas (GBM) heterogeneity. This... Read More Dr. Princess Imoukhuede from University of Illinois has developed a new quantitative receptor measurement approach for examining glioblastomas (GBM) heterogeneity. This approach is a paradigm shift in single-cell technologies: from gene-centric to proteomics. It provides never-before-seen insight into GBM heterogeneity that will ultimately enable more effective cancer treatment. It is a sensitive, quantitative approach that enables high-throughput measurements.
CRISPR-SKIP System to Modulate Expression of Exons & Improve Cellular Delivery of DNA Editing Systems Dr. Perez-Pinera has developed a new way to edit genes using CRISPR technology that promises to be safer and more efficient that existing technologies. His method uses... Read More Dr. Perez-Pinera has developed a new way to edit genes using CRISPR technology that promises to be safer and more efficient that existing technologies. His method uses single base editing, to avoid double-stranded breaks in DNA and induce a mutation that causes exon skipping to occur which can silence, knockdown or ameliorate the effects of downstream gene products. Avoiding double stranded breaks eliminates the possibility of malignant mutations which can result from improper non-homologous end joining. He also demonstrates a novel delivery method for the CRISPR-cas9 system using a split base editor inserted into an adeno-associated virus to realize greater, more efficacious delivery into the cell. This method can be used to treat diseases such as Duchenne’s Muscular Dystrophy with more permanence than current treatments as well as Huntington’s and cardiovascular diseases.
Synthetic Compound Eye Gamma Camera for SPECT Imaging Dr. Meng from the University of Illinois has developed a new synthetic compound eye (SCE) gamma camera design where each gamma camera panel consists of a large number... Read More Dr. Meng from the University of Illinois has developed a new synthetic compound eye (SCE) gamma camera design where each gamma camera panel consists of a large number micro-camera elements (MCE’s). The new deveice has the potential of 10-100 times greater sensitivity over the current commercial devices, while offering a comparable spatial resolution. It could significantly improve the capability of SPECT imaging for many diagnosis applications, such as cardiac and brain imaging.
Mechanophore Embedded in PEG Gel and PDMS Networks Dr. Li from the University of IL has developed PEG gel and PDMS networks that have mechanophore’s embedded in them and has developed a method of using Ultrasound technique... Read More Dr. Li from the University of IL has developed PEG gel and PDMS networks that have mechanophore’s embedded in them and has developed a method of using Ultrasound technique to activate the mechanophores. The invention would be useful for non-invasive procedures and allow for stimulation of neurons by illuminating the mechanophore with ultrasound waves.
Method and System for Increasing Radiation Sensitivity in Medical Imaging Detectors Dr. Abbaszadeh from the University of Illinois has invented a method and system for increasing radiation sensitivity in semiconductor detectors used in medical imaging... Read More Dr. Abbaszadeh from the University of Illinois has invented a method and system for increasing radiation sensitivity in semiconductor detectors used in medical imaging devices, such as Positron emission tomography (PET) scanners. Cadmium zinc telluride (CZT) is used in radiation detection medical applications. The cross- strip configuration of CZT detectors reduces the number of readout channels from n2 in pixelated electrode configuration to n. If there are multiple interaction photon events, multiple anodes and cathodes will be triggered at the same time and create ambiguity in determining the exact position of interaction. Generally, the multiple interaction events in cross-strip detectors are discarded. This invention will increase the sensitivity of semiconductor detectors by including these events. The sensitivity of the system is improved by nearly an order of magnitude. Schematic of box-shaped CZT-based small animal PET system.
An Epitope- and Structure-based Shigella MEFA (multiepitope fusion antigen) Protein Induces Broad Antibody Responses against Shigella spp Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by... Read More Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by Shigella bacteria. The protein is a multiepitope fusion antigen (MEFA), incorporating virulence factors which are conserved across multiple Shigella serotypes. When administered to animals, this fusion protein induces protection against Shigella epithelial cell invasion. Since virulence factors from multiple serotypes are included in the fusion protein, this protection can be extended to the various Shigella serotypes.
An Epitope and Structure-based Shigella MEFA (multiepitope fusion antigen) Protein Induces Broad Antibody Responses Against Shigella spp Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by... Read More Dr. Zhang from the University of Illinois has developed a promising candidate protein for a vaccine against Shigellosis, an infectious gastrointestinal disease caused by Shigella bacteria. The protein is a multiepitope fusion antigen (MEFA), incorporating virulence factors which are conserved across multiple Shigella serotypes. When administered to animals, this fusion protein induces protection against Shigella epithelial cell invasion. Since virulence factors from multiple serotypes are included in the fusion protein, this protection can be extended to the various Shigella serotypes.

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