siRNA Delivery System for Inflammatory Diseases

Dr. Jianjun Cheng and his research group have developed a system for delivering small interfering RNA (siRNA). siRNA can be used as a specific form of interference in the inflammation cascade that could be used to treat inflammatory diseases. The invention greatly enhances the delivery efficiency of the siRNA to the intended tissue.

Related publication: Yin, L., Song, Z., Qu, Q., Kim, K. H., Zheng, N., Yao, C., Chaudhury, I., Tang, H., Gabrielson, N. P., Uckun, F. M. and Cheng, J. (2013), Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation. Angew. Chem. Int. Ed., 52: 5757–5761. doi:10.1002/anie.201209991