Dr. Chan has developed a novel fluorescent probe, NitroxylFluor, for the detection of HNO in living cells. This fluorescent probe is highly selective for HNO, is less toxic for use in living cells, and is capable of outcompeting biologic thiols, resulting in better fluorescent detection than existing probes.
NitroxylFluor: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl, Journal of the American Chemical Society Volume139 Issue 51- Published December 27, 2017
