Expanding the Chemical Substrates for Genetic Code Reprogramming

Dr. Jeffrey Moore along with colleagues at Northwestern University has developed new nonproteinogenic substrates for use in a system that uses genetic reprogramming to create polymers. The system allows translation of polymers using substrates not used for protein synthesis. Presently over 200 substrates have been discovered, Dr. Moore has found over 40 new substrates. This technology allows for the creation of polypeptides and sequence-defined polymers in vitro and in vivo.