Dr. Kris Kilian has designed specific micropatterned surfaces as a substrate for somatic cell reprogramming. Geometric cues facilitate the reprogramming of somatic cells by providing curvature and pinch points that guide proliferation, chromatin architecture, and mesenchymal-to-epithelial transition (MET), which are major indicators of active reprogramming. The technology comprises a kit for somatic cell reprogramming that includes a micropatterned object and immobilized cell adhesion agent.
- A non-genetic method for cellular reprogramming
- Method saves time and enhances efficiency of reprogramming