A meniscus-guided solution coating technique to produce pharmaceutical nanothin films. This is a new way to manufacture personalized multilayer combination drugs, which...
A meniscus-guided solution coating technique to produce pharmaceutical nanothin films. This is a new way to manufacture personalized multilayer combination drugs, which can be beneficial to types of cancer where mono-chemotherapy is ineffective. This new technology enables a uniform deposition of thin films down to a few nm in thickness, easy alternation of the film morphology (modulation of dissolution rate) and polymorphism (control of bioavailability), and a layer-by-layer production of dosages comprised of multiple active pharmaceutical ingredients. The method is cost-competitive, scalable, and high-throughput.
Toll-like receptors (TLRs) have been shown to play a vital role in the pathogenesis of many diseases, including inflammatory diseases. Exaggerated or prolonged TLR...
Toll-like receptors (TLRs) have been shown to play a vital role in the pathogenesis of many diseases, including inflammatory diseases. Exaggerated or prolonged TLR activation leads to pathological inflammation and other diseases. Despite the need, there are no small-molecule drugs clinically available against TLR pathways. This may be due to the significant signaling complexity of TLR signaling mechanisms. Dr. John Katzenellenbogen and a team of researchers have developed a novel class of inhibitors capable of inhibiting TLR signaling. These compounds have the potential to treat various inflammatory diseases.
Researchers from University of Illinois have advanced the field of robotic surgery by introducing haptic feedback based on the 3D point cloud reconstruction technique. The...
Researchers from University of Illinois have advanced the field of robotic surgery by introducing haptic feedback based on the 3D point cloud reconstruction technique. The point cloud can be seen in the display and the doctor receives a feedback if the tip of the tool touches any unexpected region or with too great a force. The application has great potential since a small mistake can lead to death due to excessive bleeding.
Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and...
Dr. Hergenrother from the University of IL has developed a method to convert compounds of Gram-positive antibiotics to Gram-negative antibiotics. This method and compound of matter are assisted by machine learning algorithm used for finding the characteristics of successful Gram-negative antibiotics. This invention offers wide-variety of Gram-negative antibiotic compounds for patients.
