• OVPR

    The Office of the Vice President for Research facilitates collaborative research opportunities, streamlines related policies and procedures, and acts as a unified voice for U of I research.

  • UIC OTM

    The Office of Technology Management at Chicago is responsible for managing the intellectual property generated by research and educational activities at the University.

  • UIC Research Center

    Supplies a fully-equipped infrastructure and access to University resources, internship programs, world-class talent, and custom-designed business development services.

  • UI Research Park

    Provides an ideal environment for starting a high-growth technology venture, with wet-chemistry labs, office space, an array of shared equipment, server co-location facilities, and conference rooms.

  • IllinoisVENTURES

    IllinoisVENTURES is a seed and early-stage technology investment firm focused on research-derived companies in information technologies, physical sciences and life sciences, with a particular emphasis on those deriving from research conducted at the University of Illinois and other regional research institutions and federal laboratories.

Office of Technology Management, Urbana-Champaign

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Search Technologies

The research and level of innovation at the University has resulted in an impressive and balanced portfolio of technologies including everything from therapeutic treatments to new crop varieties, semiconductors to genetic algorithms, imaging agents to internet tools, and fuel cells to microfluidics.

Title Teaser Technology Numbers Inventor Name
Nexturastat, a novel Urea-based HDAC6 inhibitor effective against specific cancers

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.

DF132
Alan P. Kozikowski
Eduardo Sotomayor
Novel Isoxazole-Based HDAC6 Selective Inhibitors for the Treatment of Charcott-Marie-Tooth (CMT), a new epigenetic approach to therapy

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 

 		DF074
Alan P Kozikowski, Ph.D.
Irina Gaisina, Ph.D.
Carbazole Derivatives as G9a Methyltransferase Inhibitors for Cancer Treatment and Autophagy Induction.

G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation.

DF108 Alan P Kozikowski, Ph.D.
Atomic resolution spatial Imaging of current paths in nanoscale systems using a scanning tunneling microscope DF175 Dirk Morr, PhD
CAVE2 (TM) System

Increasingly, the Nation’s computational science and engineering research communities work with international collaborators to tackle complex global problems.

DE079
Andrew Johnson, PhD
Maxine Brown, PhD
Jason Leigh, PhD
Thomas Perterka, PhD
Daniel Sandin, PhD
Scalable Peer-to-Peer Streaming Protocol for Real Time Data

Current direct real time streaming implementations on the internet are limited by bandwidth consumption.  Peer-to-Peer streaming reduces server bandwidth requirements, but it is vulnerable to delay and reliability issues that multiply as the network scales in size.  Current Peer-to-Peer streaming implementations do not scale well and are not robust 

This scalable Peer-to-Peer protocol uses an elegant network formation and maintenance algorithm that minimizes the issues of peer churn, bum peers, and delay, providing for maximum theoretical scaling.

 

 		TF11142 Srikant Rayadurgam
Mouse model for mutant allele of the cell cycling inhibitor BARA in mice.