Treatment of Diseases Caused by Bacterial Exotoxins
Exotoxins and enterotoxins released by Staphyloccal aureus and Streptococcus pyogenes trigger massive release of inflammatory proteins (cytokines) by the immune system, which cause clinical problems in patients including: toxic shock syndrome; pulmonary infections causing pneumonia; severe atopic dermatitis and delayed wound healing. Left untreated, the body’s reaction to these toxins results in inflammation, microcapillary constriction, and eventually organ failure and death.
There are several treatments for these toxins and the reactions they cause, many involving antibiotic therapy; however, current treatments do not address inflammation associated with the toxins that remain at the site of the disease or infection. Furthermore, antibiotic-resistant strains of bacteria do not respond to antibiotic therapy.
The present technology provides a means to neutralize the toxins released by bacteria without the need for antibiotics as it binds tightly to the toxins and prevents the massive and sometimes fatal immune response.