Technologies Search
| A Set Of Algorithms And Software Package For Placement Of Standard Cell Circuits "Mongrel" |
The invention is composed of several algorithms designed for optimization of different aspects of the standard cell placement problem. This set of algorithms is embodied in the placement package that performs optimization in two phases: global placement and detailed placement (this decomposition is common among placement tools). In global placement the layout area is partitioned into a uniform grid of bins; the cells (components) of the circuit are assigned to global bins during this phase. |
Business Software, Chicago | |
| Alpha secretase regulates stem cell proliferation and cell fate determination |
Alzheimer's is a degenerative and terminal disease for which there is no known cure. The cause and progression of Alzheimer's disease is not well understood. Research indicates that the disease is associated with plaques and tangles in the brain. These plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as prions associated with protein misfolding diseases. Aβ is formed after sequential cleavage of the amyloid precursor protein (APP), a transmembrane glycoprotein of undetermined function. |
Chicago, Nervous, Neurologic, Stem cells | |
| Potent, Safe and Selective 5HT2c Agonists for the treatment of Bipolar Disorder and Schizophrenia |
Bipolar disorder is a devastating psychiatric condition that affects approximately 3 million persons in the US. It is characterized by mood disorders that range from episodes of abnormally elevated energy levels, and intense cognition followed by transient depressive states. The disease usually manifests in late adolescence or early adulthood. The extreme manic phases of the disease can be accompanied by psychotic delusion and hallucinations. |
Chicago, Nervous, Neurologic, Proteins, Genomics/proteomics | |
| 'Non-stick' Anti-Microbials for Cystic Fibrosis |
Improving the efficacy of cystic fibrosis treatments remains a challenging goal with many potential solutions.
|
Urbana-Champaign, Cellular Engineering, Antifungal, Sythesis and Analysis, Research Tools and Reagants, Therapeutic | |
| 2, 4-D Broadleaf-herbicide Resistant Transgenic Chancellor Grape |
In regions that traditionally support cereal crops, penetration of the viticulture industry has been difficult because of widespread use of 2,4-D broadleaf-weed killer on large industrial fields. Typical formulations of the ubiquitous herbicide are highly volatile and are prone to drifting long distances. |
Crops and Germplasm, Urbana-Champaign | |
| 2-Dimensional Photonic Crystal For Better Performance With Less Power |
Low cost VCSELs are currently used in data communication applications where beam quality is of little importance. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| 20alpha HSD constructs |
20alpha HSD constructs
20alpha HSD cDNA20alpha HSD GST fusion construct20alpha HSD promoter constructTruncated 20alpha HSD promoter construct |
Chicago, Cell Biology | |
| 3D Computer Reconstruction of the Velopharyngeal Mechanism |
Cleft palate reconstruction presents surgeons with large obstacles, including successful surgery planning, confirming the surgery was done correctly and alleviating the need for |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Imaging, Diagnostic hardware/software/medical devices | |
| 4.3 GHz Optical Bandwidth Light Emitting Transistor |
Semiconductor light emitting diodes (LEDs) and lasers using direct gap III-V materials, and electron-hole injection and recombination, have over the years led to numerous applications in display |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| A blood-based test for colorectal cancer screening using a miRNA panel |
Colorectal cancer (CRC) is the third leading cause of cancer and cancer-related death in the western world. In general this cancer develops slowly over the years from a small polyp up to a full metastatic cancer. Early detection guarantees an excellent prognosis with survival of over 95%. CRC screening has been shown to save lives and is highly cost effective. Several strategies have been developed for CRC screening. |
Assays, Chicago, Digestive, Oncologic | |
| A Cell-based System for High Throughput Screening of Inhibitors Against Oncogenic Transcription Factors |
Over nine million Americans living today have had a diagnosis of cancer, and a large percentage are undergoing active treatment for their disease, requiring life-long care to detect and treat recurrences, new cancers, treatment side effects, and to meet their supportive care needs. Though analysts at Merrill Lynch recently estimated that the market for cancer drugs would double to $50 billion a year in 2010, from $25 billion now, because of increased competition the sales potential for each drug is projected to fall 21 percent to 32 percent. |
ALL OF THESE, Assays, Chicago, Diagnostic biological tests/assays, Oncologic, Drug Design, Research Tools and Reagants | |
| A Composite Biosorbent for Treatment of Heavy Metal Waste Streams |
This patent-pending purification technology is a means of activating a ceramic substrate and preparing a chitosan gel that coats the surface of the substrate as well as its interstitial spaces. When used in water purification, this biosorbent provides a more efficient and less expensive method for removing heavy metals and other contaminants from water. |
Urbana-Champaign, Water | |
| A Database of Computed Atlas of Surface Topography of Proteins (CASTp) |
CASTp
(http://cast.engr.uic.edu) is an online tool that locates and measures |
Chicago | |
| A DNA-Cleaving DNAzyme-Based Fluorescent Sensor for Cu²+ Detection |
Copper is a widely used metal that can leak into the environment through various routes. |
Urbana-Champaign | |
| A Drawing Process for the Continuous Fabrication of Nanowires |
Electrochemistry has been used to fabricate various metallic nanostructures, due to its versatility for plating and surface finishing of a wide range of materials, through two
traditional methods. |
Processes, Urbana-Champaign | |
| A fluorescent sensor for Hg²+ detection |
Sensors that can detect mercury with high sensitivity and selectivity are very useful in preventing mercury poisoning as well as understanding its distribution.
Most fluorescent sensors for Hg²+ dete |
Urbana-Champaign | |
| A High Speed, High Precision Micro and Nano-Scale Cutting Machine |
Photolithography, a method for manufacturing grooves into surfaces of silicon primarily for the design and manufacture of electronics, has certain limitations when dealing with particular groove shapes and geometries as well as hard materials like metals. These limitations tend to hinder applications in other areas. Additionally, the complicated nature of using photolithography for prototypical product design is an issue that is of increasing importance as these designs become more complex. |
Processes, Urbana-Champaign | |
| A Joint Decoding and Equalization Algorithm for increased efficiency and lowered complexity in digital communication systems |
Reduce signal distortion and system complexity and increase computational efficiency in digital communications systems with an algorithm that combines the equalization and decoding tasks into one proc |
Urbana-Champaign | |
| A liquid-repellent, electrically conducting polymer coating for ice prevention/removal and EMI shielding |
Polymer nanocomposites are a new class of materials in which the filler substance is made up at least partially of nanoparticle elements such as carbon nanofibers, carbon nanotubes, nanoclays and other more exotic nano structures. These compounds can provide some very desirable properties for novel coating materials: mechanical strength, good electrical conductivity, and improved thermal and chemical resistance. These combinations of features have propelled these polymer compounds into one of the fastest growing plastic segments. |
Chicago, Energy, Environmental Sciences and Materials | |
| A Method for Chemical Ligation to Cysteine and other Thiols |
Development of efficient chemical ligation methods for the attachment of small molecules to peptides |
Chicago, Drug Design, Research Tools and Reagants |
|
| A Method for Compensating Wave Reflections in Transmission Lines |
This technology is a method to eliminate voltage overshoot in cables used to connect AC electric motors and pulse width modulation (PWM) inverters. As a function of cable length and voltage rise time, voltage overshoot occurs when high frequency currents reflect between the motor and source ends of a cable. University of Illinois researchers have devised a compensator that shapes the output of the PWM inverter in order to eliminate these reflections; the method only requires knowledge of the transmission line characteristic impedance and propagation delay. This technique e |
Power devices, Urbana-Champaign | |
| A Method for Precise Control of Alignment of Nanomaterials on a DNA Template |
The field of materials science has recently gained the ability to assemble singly-functional nanomaterials to DNA backbones; however, future applications for this technology (in electronics and p |
Urbana-Champaign | |
| A Method of Fabricating Free-Standing Flexible Substrates for Sensors and Electronics |
This technology allows significant advances in the application of sensing technology. The invention is a method for more efficiently creating superior substrates that are flexible in three dimensions and can be worn, attached to moving objects, or used to produce truly flexible displays. |
MEMS Devices, Urbana-Champaign | |
| A Method to Produce Janus Particles in Large Quantity |
This innovation provides a simple and generalizeable method to synthesize Janus colloidal particles in large quantity. Janus particles offer unique opportunities in particle engineering for building particular structures; offering insight into the movement of particles and serving as a basis for new materials and sensors. Earlier methods to produce Janus particles of colloidal size (≤1μm in dimension) have been severely limited in the amount of product, but this method has overcome limitations on yield. |
Urbana-Champaign | |
| A Micro-Machined Parallel-Plate Tunable Capacitor with a Wide Tuning Range |
Integrated wireless communications systems require tunable capacitors that have a wide tuning range, low loss, and monolithic integration. This new MEMS tunable capacitor perfectly meets those needs. |
MEMS Devices, Urbana-Champaign | |
| A MicroNano Fiber Testing Device |
Electro-spinning is a method for mass production of long polymeric nanofibers in a continuous non-woven form. The large variability in fabrication conditions and parameters in conjunction with the large surface-to-volume ratio of individual fibers can give rise to a spectrum of mechanical behavior that may deviate significantly from bulk.
This invention uses a micro-device as a miniature stress machine and an optical microscope to capture the motion of said micro-device. |
MEMS Devices, Urbana-Champaign | |
| A monoclonal antibody recognizing human p-glycoprotein in intact cells (UIC2) | Chicago | ||
| A More Stable and Efficient Retroviral Gene Delivery Vector |
Gene therapy has been called the "next big thing" in medicine for the past several years; however, its progress has been hampered by numerous difficulties in the development process such as |
ALL OF THESE, Neurologic, Oncologic, Urbana-Champaign, Drug Design, Antiviral, Research Tools and Reagants, Therapeutic | |
| A Multifunctional, Active Probe Array for Nano-Patterning and Imaging |
This invention is a novel multifunctional probe array that allows for both dip-pen nanolithography (DPN) and scanning probe contact printing (SPCP) along with a dedicated imaging tip. Each probe can be independently lifted from the substrate surface, so that either a writing or imaging tip is engaged on the surface at all times. This eliminates the need to load a new probe, which causes time delays and the need for recalibration. |
MEMS Devices, Urbana-Champaign | |
| A Natural Cross-Linking Agent for Use in Restorative and Preventative Dental Treatment |
Modern dentistry focuses on three segments of care: preventive measures, corrective procedures, and restorative treatments. Restorative treatments deal with the restoration of diseased, injured, or abnormal teeth to normal function. It includes all aspects of Endodontics, Periodontics and Prosthodontics. The practice involves combining the traditional techniques of dental arts with scientific (physical, chemical and biological) advances in materials and equipment. Advances in the practice of Dentistry, and in the materials used, have been significant in the last few decades. |
Chicago, Dental, Integumentary, Therapeutic | |
| A New Cancer Therapy Using Folate/Anti-T-Cell Antibody Conjugates |
This technology is a process for killing tumor cells using the body's own immune system to selectively seek out and destroy cancer cells. Tumor cells are targeted for lysis using an anti-T-cell-receptor antibody that is conjugated to folate or a folate analogue. The antibody-folate conjugate targets and binds to the folate-receptor-positive (FR+) tumor cells, resulting in tumor cell death. This technology can also be adapted to use antibodies for other effector-cells such as natural killer cells, monocytes, and macrophages. |
Urbana-Champaign | |
| A new family of compounds for HIV therapy |
Researchers at the University of Illinois have developed a family of novel, synthetic nucleoside analog inhibitors of viral reverse transcriptase (RT) that could potentially offer new treatment option |
Urbana-Champaign, Cell Biology, Cellular Engineering, Research Tools and Reagants | |
| A New Nixtimalization Process |
Working together, researchers at the University of Illinois and the University of Sinaloa, Mexico, have developed a new method of nixtamalization, the process of treating corn in an alkaline solution, that yields a higher-quality masa dough and/or instant masa flour than traditional nixtamalization processes. |
Crops and Germplasm, Urbana-Champaign | |
| A new shape concept for electrode contacts used for peripheral nerve stimulation and subcutaneous neurostimulation |
Currently available neurostimulation electrodes have cylindrical, flat, or slightly convex geometrical shapes. These designs work well with spinal cord and deep brain stimulation but their geometries do not work well to stimulate peripheral nerves. UIC researchers have proposed a non-traditional shape of the electrode contacts that changes the way electrical device interfaces with biological tissues and electrical energy of stimulation is delivered to the stimulation targets. |
Nervous, Diagnostic hardware/software/medical devices | |
| A novel antibiotic effective against drug-resistant bacterial strains |
Antibiotic resistance is a global problem with increased prevalence and sometimes deadly outcomes which showcases the need for drugs designed to overcome this epidemic. With increasing rates of bacterial drug resistance, the development of new antibiotics has become a crucial focus of the medical community. However, despite this well-established need, the U.S. FDA still only approved 13 new antibiotics in 2010-2011. |
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| A novel cardiac specific blood biomarker for diastolic heart failure |
There are 1.4 million patient visits per year in the U.S. |
Cardiac, Chicago, Circulatory, Diagnostic biological tests/assays, Immunoassay | |
| A Novel Device Platform for Electrode Insertion Procedures Used in Neurostimulation |
In
peripheral nerve stimulation and subcutaneous neurostimulation procedures, a neurosurgeon
inserts a wire-type electrode into the body using a straight needle and stylet
device. Because this needle and stylet
are straight, it is difficult to insert to match the natural curves of the
human body. To solve this problem, a surgeon
often bends the device in the operating room, creating rough kinks and
inconsistent bends in the needle and stylus.
These limitations make it difficult to remove and reinsert the stylus for
electrode insertion. |
Chicago, Nervous, Neurologic, Therapeutic hardware/ software/medical devices | |
| A novel kinase drug target for non-small-cell lung cancer |
Non-small cell lung cancer is prevalent in over 75% of all lung
cancer incidence, with over 50% of the diagnoses coming in the advanced stage
of the disease. With over 150,000 new
cases expected to be diagnosed and over 155,000 lung cancer patients expected
to die in 2010, research into understanding and combating this deadly illness
is greatly needed. Novel approaches to
gaining understanding and advances in this arena are highly prized; one such
area deals with non-muscle myosin light chain kinase (NM-MLCK). This kinase is a very important enzyme in the
mechanism |
ALL OF THESE, Chicago, Oncologic, Drug targets, Research Tools and Reagants |
|
| A novel method and medical device for detecting auditory problems. |
Our ability to follow verbal instructions is dependent on the proper functioning of the middle ear muscles. This is more difficult as the acoustical features in our modern environment becomes more complex and noisy. Currently, middle ear muscle function is monitored through clinical tympanometry and acoustic reflex (AR) testing. These clinical tools are sensitive to severe damage in the neural regulation of the muscles and growth deformations of the bone structure. |
Auditory, Chicago, Diagnostic hardware/software/medical devices | |
| A Novel Method for Prevention and Treatment of Narrowing of Cerebral Blood Vessels (NCBV) |
Narrowing
of cerebral blood vessels (NCBV) is a pathological condition that frequently
develops after subarachnoid hemorrhage and leads to impairment of cerebral
blood flow, cerebral oxygen delivery and subsequent cerebral ischemia and
stoke. It affects up to 60% of patients with hemorrhage after rupture of
intracranial aneurysms. Spinal cord
stimulation (SCS) is an established modality that is widely used to treat all
kinds of chronic pain, primarily neuropathic in origin |
Chicago, Nervous, Neurologic, Noninvasive device, Therapeutic hardware/ software/medical devices | |
| A Novel Prostate Cancer Vaccine with Eight Years of Clinical Data and Full Human Genome Profiling |
According to the American Cancer Society, prostate cancer is the second leading cause of cancer death among men in the US. It is estimated that more than 200 thousand new cases are diagnosed every year and more than 30 thousand will die of this disease. |
Chicago, Oncologic, Reproductive, Immunotherapy, Therapeutic | |
| A Novel Series of Indole-2-carboxyamide Derivatives with Potentially Higher Activity against Mtb than Isoniazid |
Tuberculosis
has become one serious disease all over the world, especially MDR-TB and
XDR-TB. In College of Pharmacy at UIC, scientists, who work in TB drug
discovery, found a compound -- indol-2-carboxyamide to be active against
mycobacterial tuberculosis (Mtb) in a high throughput screening campaign. Based
on this structure, a series of novel indole-2-carboxyamide derivatives were
prepared and showed excellent activities against actively replicating Mtb. |
Chicago, Infectious, Respiratory, Antibiotic | |
| A Novel System For Discovery Of Gene Function By Protein Surface Matching |
Proteins function by interacting with other molecules such as substrates and drugs, but the function |
Chicago | |
| A novel technology to facilitate new attachment of teeth |
There are a number of options for the replacement of missing teeth. Dental implants and implant-supported bridges are available as permanent solutions and removable dentures and dental bridges are common non-surgical treatment options. Implants have the benefit of strength and durability and can be used along with bridges or independently. They also generally do not necessitate any alterantion to the shape of the surrounding teeth. It has been shown that people with implants eat better and are healthier and enjoy life more than people with dentures. |
Chicago, Dental, NONE OF THESE, Gene and Cell Therapy, Therapeutic | |
| A Novel Transcriptional Inhibitor ARC Induces Apoptosis in Tumor Cells and Exhibits Anti-Angiogenic Activity |
Cancer is recognized as the second leading cause of death worldwide. When the
balance between cell
proliferation and cell death is disrupted, the ensuing aberrant proliferation
leads to tumor growth.
Cancer treatment is still largely achieved through the use
of chemo
and radiotherapy, both of which cause various side-effects. Treatments
which are tailored for
specific tumors with minimum side- effects are the ultimate
goal of
cancer therapy. For certain types of tumors which
express labile anti-apoptotic proteins, repression of cellular
transcription could be
useful. |
Chicago, Gender-specific disorders, Oncologic, Reproductive, Therapeutic | |
| A Novel Zero-Voltage-Switching Scheme for Photovoltaic/Fuel-Cell-Based High-Frequency-AC-Link Inverter | Chicago, Energy, Environmental Sciences and Materials |
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|
| A Process for the Formation of Glycosidic Bonds from Thioglycosides in Solution and on Polymer Supports |
The field of Glycobiology has grown tremendously over recent years and many different types of disea |
ALL OF THESE, ALL OF THESE, Chicago, Sythesis and Analysis, Research Tools and Reagants | |
| A Series of 5-methylthiazole Analogs derived from Clomethiazole for the Treatment of Alzheimer's Disease |
Clomethiazole (CMZ) is a sedative/
hypnotic, anticonvulsant, currently in clinical use for anxiety in the elderly
via its GABA-mimetic and anti-inflammatory actions. Besides acting as a GABAA potentiator,
CMZ was also proposed to inhibit the p38 mitogen-activated protein kinase
pathway and decrease inducible nitric oxide synthase (iNOS) expression in
cortical glial cells. |
Chicago, Nervous, Neurologic, Anti-inflammatory | |
| A SNP mutation associated with lower warfarin dose requirements (cytochrome P450 2C9*8 allele) |
Warfarin is the oral anticoagulant most frequently used to control and prevent thromboembolic disorders. It exerts its anticoagulant effects by inhibiting the synthesis of vitamin K-dependent clotting factors.
Prescribing the dose that both avoids hemorrhagic complications and achieves sufficient suppression of thrombosis requires a thorough understanding of the drug's unique pharmacology. Warfarin has a complex dose-response relationship that makes safe and effective use a challenge. |
Chicago | |
| A transgenic mouse model of pulmonary arterial hypertension (PAH). |
Over a quarter of a million individuals a year are hospitalized for pulmonary arterial hypertension (PAH). Survival rates of these patients are typically less than 3 years post diagnosis and there is currently no cure or tractable animal model for PAH. Researchers in Pediatrics at UIC have developed an animal model by crossing two strains of mice with conditional transgenes. |
Chicago, Circulatory, Pulmonary, Disease Model | |
| A virostatic ZnO particle for preventing topic spread of Herpes simplex virus-1 (HSV-1) |
There is no cure for herpes and current medications only treat the symptoms of the virus. UIC inventors have developed ZnO based micro‐nano particles that multivalently bind to HSV-1, rendering them un-infectable. |
Chicago, Infectious, NONE OF THESE, Antiviral | |
| Accelerated Testing and Validation of a Physician Order Entry Decision Support System through Semi-Automated Data Entry |
Preventable medical errors are common cause of patient safety problems. Two common types of physici |
Chicago | |
| Activation by two recombinant naturally occurring myeloid proteins of an anti-inflammatory and anti-hypoxic pathway |
S100 proteins are small calcium-binding proteins that are found at high levels in the extracellular milieu during inflammatory conditions. The UIC inventor has discovered that these proteins possess significant anti-inflammatory and anti-hypoxic activity. It was also shown that S100 proteins inhibit the activation of peripheral neutrophils by activating a specific type of PKC known for its anti-inflammatory activity, and have a protective effect against hypoxia. |
ALL OF THESE, ALL OF THESE, Chicago, Rheumatologic, Drug targets, Proteins, Genomics/proteomics, Research Tools and Reagants | |
| Activation of p21 activated kinase-1 by C2/C6 ceramides as a novel therapeutics alternative of beta blockers for systolic heart failure and ischemic heart disease | Cardiac, Chicago, Circulatory, Therapeutic | ||
| Active Interactive Genetic Algorithms for Reducing User Fatigue and Boosting Evaluation Consistency in Search-Based Domain |
Interactive genetic algorithms (iGAs) depend on the evaluations or decisions provided by a user. The reliability of those evaluations is key for the successful application of iGAs. However, even moderately-sized problems my require thousands of evaluations that are sometimes between rather similar solutions which can lead to frustration and inconsistent evaluations. This invention provides a scheme for actively combating user fatigue and inconsistency in iGAs. |
Business Software, Urbana-Champaign | |
| Adaptive Acquisition and Reconstruction of Dynamic Magnetic Resonance Images |
This invention is a new method for real time cardiac magnetic resonance (MR) imaging that produces high-spatial and temporal resolution motion movies of the beating heart non-invasively using a MRI scanner, even in the presence of breathing. |
Urbana-Champaign, MR, Diagnostic hardware/software/medical devices | |
| Advancements for Cardiac Hypertrophy Therapeutics |
Cardiac
hypertrophy occurs in response to increased stress on the heart. The transition from cardiac hypertrophy to
heart failure is primarily attributed to excessive cardiomyocyte growth which
is similar in some ways to tumor growth.
UIC inventors have developed Pak1 knockout mice to assist in providing
data for novel therapeutic strategies for cardiac hypertrophy. The inventors have conducted experiments
showing Pak1 may be an anti-hypertrophic player. Ultimately, through experimentation, the
inventors have identified several novel advances regarding Pak1 ac |
Chicago | |
| AFM Cantilever for Measuring or Actuating Temperature-Dependent Electrical Potential with Nanometer-Scale Resolution |
Temperature limits the sensitivity and resolution of every surface electrical potential measurement made by an AFM today. With existing AFM probes, temperature and current cannot be modulated, thus it is difficult to control temperature or to measure electrical potential
at the tip.
This device uses an integrated resistive heating element and temperature controls to combine temperature applications with voltage measurements to remove the uncertainty of temperature in surface electrical potential
measurements. |
Sensors, Urbana-Champaign | |
| Aligned Free-Standing Copper Nanowires |
This invention fabricates copper nanowires using thermal chemical vapor deposition (CVD) at temperatures of about 200º to 400º C. The method can produce vertically aligned copper nanowires on various metallic, oxide, and plastic substrates without the need for pores, templates, catalysts, or lithography of the substrate surface. The CVD process does not use hydrogen and is compatible with standard silicon processing technologies. |
Non-MEMS Devices, Urbana-Champaign | |
| Alkaline Chemistries in Microfluidic Fuel Cells |
This fuel cell is an invention of miniature proportions. UIUC researchers have developed the ability to integrate alkaline and mixed-media electrochemistries into microfluidic fuel cells. This technology takes advantage of two well documented phenomena: 1. the high output of alkaline electrochemical reactions; and 2. the reliable, low-maintenance qualities of laminar flow.
Microfluidic alkaline fuel cells eliminate the need for a semi-permeable membrane (PEM) and operate under the unique principles of laminar flow in which substances interact without experiencing turbulent mixing. |
Renewable Fuels, Urbana-Champaign | |
| Altered Intracellular Localization of the BRK/ Sik protein Tyrosine Kinase in Human Prostate Tumors |
Brk is an intracellular protein tyrosine kinase that is significantly over expressed in a majority of breast tumors, while being detected at appreciable levels in only a limited range of adult tissues that does not include the mammary gland. It has recently been demonstrated to have a role in promoting the proliferation of carcinoma cells, one that it is unlikely to perform in normal adult cells, and it therefore represents an exciting target for the development of novel cancer therapies based on specifically or selectively interfering with its functions. |
Chicago | |
| Ambient Temperature Conductive Ink Process |
Researchers at the University of Illinois have developed a room temperature process to orient ink particles to enhance conductivity. |
Urbana-Champaign | |
| An Adult Human Blood-Derived Cell Population Displays Embryonic Markers and High Potential Giving Rise to Insulin-Producing Cells |
Developing a more ethically acceptable alternative to embryonic stem (ES) cells will radically advance treatment of human dominant diseases. One potential therapeutic application of ES cells is to treat Type I Diabetes, which is characterized by the loss of insulin-producing pancreatic, or beta, cells. Recent studies suggest that, under the right conditions, ES cells can differentiate to insulin-producing cells that could be transplanted into the pancreas of Type I diabetic patients as a cure for this disease. |
Chicago, Endocrine, Endocrine, Therapeutic | |
| An analysis test to screen for the potential risk of sudden cardiac death, focusing on the splicing abnormalities of the cardiac voltage gated sodium channel (SCN5A) mRNA |
Hypertrophic
cardiomyopathy (HCM) leading to sustained ventricular tachyarrhythmias is the
most common cause of sudden cardiac death (SCD) in young patients. Previously,
it was shown that adult patients with heart failure (HF) at increased risk of
SCD have increased abundance of alternatively spliced mRNA for the cardiac
voltage gated sodium channel (SCN5A) mRNA. These splice variants encode
nonfunctional sodium channels that contribute to arrhythmic risk. |
Chicago | |
| An Environmentally Friendly Process for Oxidation of Alcohol Using Crystaline Recyclable, Fluorous-Tagged Sulfoxide |
The controlled oxidation of primary and secondary alcohols to aldehydes and ketones is one of the mo |
Chicago, Sythesis and Analysis, Research Tools and Reagants | |
| An experimental five level version of the EQ-5D and item-response based method to crosswalk between existing 3 level reference-based algorithms and the experimental EQ—5D 5 level version |
The standard EQ-5D developed by the EuroQol group discriminates 3 levels of health. It is a statistical survey to measure the self reported assessment of the health status of the patient. The measure is widely used by the pharmaceutical industry in clinical trials. The group has an algorithm of the system to 5 levels, and then used a novel approach to crosswalk between the 3 level and 5 level system in order to adapt existing 3 level algorithms to the experimental 5 level system. |
Chicago, Other | |
| An imaging technique for quantitative mapping of retinal oxygen tension |
For retinal cells to maintain normal metabolic function, they demand oxygen and nutrients . Various conditions, like acute retinal artery embolic disease, retinal vein occlusion and retinopathy of prematurity, are associated with abnormalities in retinal oxygenation and are implicated in the development of glaucoma and age-related macular degeneration. |
Chicago, Ocular, Ophthalmalogical, Imaging, Diagnostic hardware/software/medical devices | |
| An Integrated Localization, Routing and Indexing Architecture and Algorithms for Wireless Sensor Databases |
A node is any device connected to a computer network. A wireless network is composed of autonomous sensors as the nodes, each with its own storage, processing, communication and power capabilities, distributed over the geographic space. As its size grows and as sensors acquire complex functionalities, the volume of data gathered, manipulated and communicated across the network increases dramatically. |
Chicago | |
| An Organic-Inorganic Nanocomposite Film For Photovoltaic And Optical Limiting Applications |
Photovoltaic cells are a novel way of converting solar energy into some usable form of energy. Thi |
Chicago, Solar | |
| Analog and Digital Applications Coupled Cavity VCSELs |
Optical communications have become a main method of high-speed data transmission and are at the forefro |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Antenna Selection for Wideband MIMO System |
This invention is method of pre-computing the optimal pairing of antennas to RF/ analog frontends in wireless MIMO systems without the need for computationally complex and power consuming searches.
O |
Urbana-Champaign | |
| Anti – inflammatory and immunomodulatory effects of GLP – 1 in lipid based formulations |
Glucagon-like peptide-1 (GLP-1) is a 30-mer peptide hormone secreted by intestinal L-cells that bind to GLP-1 receptor on the β-cell and stimulates insulin secretion in response to ingested carbohydrates and lipids. Native GLP-1 peptide, however, has limited applications as a therapeutic agent due to its rapid elimination in vivo. A number of GLP-1 analogs with longer half-lives have been synthesized and approved for treatment. The aqueous solubility of the peptide is low. |
Autoimmune, Chicago, Infectious, Lymphatic, Muscular, Nervous, Pain, Renal, Reproductive, Rheumatologic, Urinary, Anti-inflammatory, Therapeutic | |
| Anti-Prostanoids as treatment for Sleep Apnea |
Sleep apnea is a potentially life-threatening disorder characterized by temporary breathing interruptions during sleep. Sleep apnea is usually accompanied by snoring and results in daytime fatigue and other disabling characteristics. According to the National Institute of Health, more than 15 million Americans are affected with sleep apnea including 25% of middle-aged men and 10% of middle-aged women. |
Chicago, Nervous, Neurologic, Therapeutic | |
| Antibodies against b-Chain Associated Regulator of Proliferation (BARP) | Chicago | ||
| Antithrombotic and Anticoagulant Peptides that Inhibit Signaling Via Specific G Protein Subunit Switch Regions |
In the last decade the incidence of thrombo-embolic diseases in which anti-platelet drugs may have been beneficial was estimated to be 2,500,000 patients affected by coronary artery diseases, 873,000 patients with cerebrovascular disease, i.e., stroke or transient ischemic attack, and 2,000,000 patients with peripheral arterial occlusive disease. However, even though G protein signaling pathways are known to be intimately involved in the genesis of thromboembolic events, it has not been possible to pharmacologically target G proteins as a means of decreasing blood platelet functi |
Chicago, Genomics/proteomics | |
| Antithrombotic Membrane Permeable Peptides that Inhibit the Interaction of Platelet Adhesion Receptor, Glycoprotein Ib-IX, with von Willebrand factor |
In the last decade the incidence of thrombo-embolic diseases in which anti-platelet drugs may have been beneficial was estimated to be 2,500,000 patients affected by coronary artery diseases, 873,000 patients with cerebrovascular disease, i.e., stroke or transient ischemic attack, and 2,000,000 patients with peripheral arterial occlusive disease. The interaction between the platelet glycoprotein (GP) Ib-IX complex and von Willebrand factor (VWF) is known to initiate both hemostasis and pathological thrombosis, particularly in arteries and capillaries. |
Cardiac, Chicago, Circulatory, Proteins, Genomics/proteomics | |
| Antithrombotic Membrane Permeable Peptides that Inhibit the Interaction of Platelet Integrin αIIbβ3 with Src Kinase |
In the last decade the incidence of thrombo-embolic diseases in which anti-platelet drugs may have been beneficial was estimated to be 2,500,000 patients affected by coronary artery diseases, 873,000 patients with cerebrovascular disease, i.e., stroke or transient ischemic attack, and 2,000,000 patients with peripheral arterial occlusive disease. Platelet integrin signaling pathways mediate cell adhesion and transduce critical signals in the dynamic regulation of cell adhesion, spreading, migration, and proliferation. Integrin signaling is bidirectional as exemplified in the pro |
Cardiac, Chicago, Circulatory, Therapeutic | |
| AOXADUR Antioxidant Treatment for Increasing Service Life of Asphalt Mixtures |
Background
Chemical binders used in asphalt paved surfaces are subject to age-hardening, resulting in increased stiffness over time, a major cause of cracking and the subsequent need for re-surfacing.
|
Highways and Roads, Urbana-Champaign | |
| Apparatus and Methods for Dilating Vasospasm of Small Intracranial Arteries |
Intracranial vasospams are often delayed complications that develop in patients with ruptured brain aneurysms. Current treatment involves either pharmacologic intervention or mechanical dilation using a specialized low-radial-pressure compliant balloon microcatheter. However, due to limitations in this mechanical balloon treatment, microcatheters cannot be maneuvered into smaller and more tortuous vessels and therefore only the larger, proximal vessels are treated. This poses a large health threat to those who need full vessel treatment to control the vasospasm. |
Chicago, Nervous, Neurologic, Invasive device, Therapeutic hardware/ software/medical devices | |
| Apple Tree Co-op 43 ( "Juliet") |
Researchers at the University of Illinois have developed a highly productive late-season red apple tree. Resistant to apple scab disease, the tree produces apples of exceptional "Juliet". Co-op 43 is the 15th apple cultivar developed by the cooperative breeding program between the University of Illinois, Purdue University, and Rutgers University. |
Crops and Germplasm, Urbana-Champaign | |
| Application of GFP-forkhead fusion proteins for high throughput, cell-based assay of Akt activity |
Akt is an enzyme that plays a critical
role in the regulation of cell survival and mediating effects of insulin on
glucose metabolism. The Factors, which activate Akt, may provide important
therapeutic tools in the treatment of neurodegenerative disorders. The mammalian
transcription factors, FKHR, FKHRL1 and AFX, function as key regulators of
insulin signaling, cell cycle progression and apoptosis downstream of
phosphoinositide 3-kinase (PI3K). Forkhead proteins function as classical
transcriptional activators and target genes encoding pro-apoptotic proteins
(e.g. |
Chicago | |
| Archon: Simple Archival System |
Archon: Simple Archival System (SAS) is a tool allowing for easy management of information about archives and manuscripts, and automatic publishing of archival findings in a web-based environment. It exports data in standard bibliographic and archival formats, such as MARC (Machine Readable Cataloging) and EAD (Encoded Archival Description).
Archon allows for the organization of records into a user defined classification scheme. Archon is written in PHP and will run on any hardware and operating system supporting PHP 5 and a MYSQL or SQL Server database. |
Database, Urbana-Champaign | |
| Aryl naphthalide lignans as anti-HIV agents |
There is an estimated 33 million individuals that are infected with the HIV worldwide.
Currently, there are many anti-HIV therapeutic drugs in clinical use. Although these drugs have significantly extended the life span of HIV-positive people in wealthy countries, they are non-curative and suffer from diminishing effectiveness due to the development of viral resistance. In addition, many of the existing treatments have adverse side effects that erode patient quality of life. |
Chicago, Infectious, Antiviral, Therapeutic | |
| Assembly Method for Three-Dimensional MEMS Saves Chip Space Using Single Magnetic Actuation for Large Arrays of Devices |
This technology is an efficient process for assembling large arrays of three-dimensional, hinged micro structures for micro electromechanical systems (MEMS) applications. Using a single electromagnet for actuation, this new method saves chip space as well as actuates large arrays of devices in parallel. It makes fabrication of MEMS devices more reliable and simple by eliminating the need for biasing several actuators and not requiring a constant source of energy for actuation. |
MEMS Devices, Urbana-Champaign | |
| Atomic resolution spatial Imaging of current paths in nanoscale systems using a scanning tunneling microscope | Chicago, Micro/nano scale (non-electronic) | ||
| Auto-Calibrating Parallel MRI Technique with Distortion-Optimal Image Construction |
Magnetic Resonance Imaging (MRI) is a medical imaging technique most commonly used in radiology to visualize the internal structure and function of the body. |
Urbana-Champaign, Imaging, MR, Diagnostic hardware/software/medical devices |
|
| Autoimmune Diabetes Biomarkers for Diagnosis and Treatment |
Latent Autoimmune Diabetes of Adults (LADA) is a genetically‐linked, hereditary autoimmune disorder characterized by a delayed‐onset of Type 1 diabetes in adults. Patients with LADA are frequently misdiagnosed as having Type 2 diabetes based on age, not etiology. It is hypothesized that up to 20% of people diagnosed with Type 2 diabetes may actually have LADA. |
Chicago | |
| Automated Cancer Detection and Tissue Classification |
This
portfolio focuses on the automated detection of two prevalent types of cancer:
breast and prostate. Both types of
cancer are very prevalent, impacting many individuals per year. Manually-conducted histological assessment of
potentially cancerous tissue by a highly trained pathologist forms the current
gold standard of diagnosis. Several
samples are usually taken and several sections from each section are examined:
roughly 20 to 120 sections are examined per patient—frequently by more than one
pathologist. Such manual assessment
suffers from several limi |
ALL OF THESE, Oncologic, Urbana-Champaign, Imaging, Diagnostic hardware/software/medical devices |
|
| Automated Maintenance of Problem-Drug Matches in the Electronic Medical Record to Promote Patient Safety |
The advent of electronic medical records (EMRs) with computerized physician order entry (CPOE) makes |
Chicago | |
| Battery Having a Built-In Controller |
This invention comprises a series of 7 patents and 2 patent applications describing single and multi-cell batteries having electronic circuitry interposed between the electrochemical cells and the battery terminals. |
Chicago, Non-MEMS Devices | |
| Biodegradable Implants and Matrices for Tissue/Bone Repair |
These technologies provide biodegradable bone implants and artificial bone matrices for bony tissue repair. |
Urbana-Champaign | |
| Biomarkers for Prediction of Stroke Risk in Atrial Fibrillation |
Every year in the United States more than 775,000 people experience a stroke, with one occurring on average every 40 seconds. Accounting for about one of every 18 deaths in the United States, the condition ranks third among all causes of death. With only a four hour therapeutic window, stroke is also a leading cause of long-term disability. The estimated direct and indirect cost of stroke in 2010 is estimated to be $73.7 billion dollars; as a result, there is a growing market for risk determining methods for stroke, especially in patients with atrial fibrillation (AF), the |
Assays, Cardiac, Chicago, Circulatory, Diagnostic biological tests/assays, Neurologic | |
| Biomarkers for Rheumatoid Arthritis (RA) diagnosis, treatments, and efficacy assessment |
Rheumatoid Arthritis (RA) is an autoimmune disease that attacks a person’s own joints and surrounding tissue. The UIC inventors have identified ligands and receptors that are elevated in RA as targets for pharmacological treatments and clinical diagnostic assays. |
Chicago, Diagnostic biological tests/assays, Rheumatologic, Skeletal, Immunoassay |
|
| Biomimetic 3D Scaffolds for Bone and Dental Pulp Tissue Regeneration |
Loss of dental and craniofacial tissues due to disease, injury or genetic disorders negatively affects the quality of life of millions of Americans. Presently, the gold standard in clinical treatment for craniofacial bone defects is autografts and demineralized bone matrix (DBM). Autografts perform exceptionally well, but are known to induce donor site morbidity and DBMs poorly induce regeneration of lost tissue. |
Chicago, Digestive, Skeletal, Biomaterial, Cellular Engineering | |
| Biomimetic Device for Tumor Cell Capture |
Cancer
remains one of the world’s most devastating diseases, accounting for over 500,000 deaths in the United States and nearly 8 million worldwide in 2007. Although recent advances in diagnostic and therapeutic
methods to treat primary tumors have resulted in a decrease in mortality from the disease, cancer metastasis still poses a great
risk to those who have undergone treatment. The detection of spontaneous circulating tumor cells (CTCs) and/or tumor microemboli (CTM) would give physicians an early heads-up on the spread of the disease. |
Chicago, Circulatory, Oncologic, Diagnostic hardware/software/medical devices | |
| Biosynthesis of Lantibiotics: In vitro semi-synthetic production methods for generation of industrial antibiotic, Lacticin 481 |
This invention allows the engineering of semi-synthetic lantibiotics to a much larger extent than using typically practiced in vivo methods. The method is the first in vitro reconstruction lantibiotic photosynthesis and introduces non-proteinogenic amino acids. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Antibiotic, Therapeutic | |
| Biosynthesis of Silver Nanoparticles (SNP) by Fungus Trichoderma Reesei: A Route for Large-Scale Production of SNPs | Chicago | ||
| Buried Tunnel Contact Junction For Better Performance With Less Power |
In many semiconductor light emitting devices, minimizing the volume of the p-type material is desirable. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| CACL: A Context-Aware Cross-Layer Broadcast Scheduling Scheme |
Broadcasting is commonly used in ad hoc networking to build routes to unknown destinations. In static topologies, broadcasting is rarely used - a routing path between any two nodes must only be learned once. In dynamic topologies (typified by high mobility) learned routes can be ephemeral. Mobility effects are exacerbated by network traffic, which increases forwarding delays at each hop on a routing path. With increasing mobility and network traffic, routes must be built at shorter intervals. |
Chicago, Networking/Data Transmission | |
| Calibration of counter-current and partition chromatographs and columns |
High speed countercurrent chromatography (HSCCC) and centrifugal partition chromatography (CPC) are the major techniques that are used for the separation of a large variety of natural products. Proper selection of a biphasic solvent system for counter-chromatography (CCC) separations is very important because in CCC, the solvent acts as both the column as well as the eluant. But the lack of a clear method for comparing the many possible biphasic solvent systems or solvent system family performance seems to be a major impediment in more widespread use of these techniques. |
Chicago, Chromatography, Research Tools and Reagants | |
| Cancer screening and monitoring using computer software |
Late
diagnosis is considered a major cause of high incidence of oral cancer
(OC). OC is the 11th most common cancer
in the world. Almost all oral cancers
are squamous cell carcinomas, since squamous cells line the oral cavity. Biopsy can determine whether an abnormal area
in the oral cavity is cancerous. However,
a method for early diagnosis is imperative to reduce incidence of the disease. The inventor proposes that software based on
fractal dimension (FD) patterning can be used to analyze oral cancer
histological samples. FD is a variable
for m |
Chicago | |
| Cancer Vaccine for Prevention of Angiogenesis |
Angiogenesis
is a multi-step process involving degradation of the extracellular matrix, and
then migration, proliferation, and re-differentiation of endothelial cells into
patent vessels. Angiogenesis is normally observed under transient physiological
conditions such as embryogenesis, wound healing, and reproductive functions in
adults. Under pathological conditions such as cancer, abnormal angiogenesis
supports the survival and progression of human tumors. |
ALL OF THESE, Chicago, Oncologic, Vaccines, Therapeutic | |
| Candidate target genes for breast cancer treatment |
Identification of genes as novel potential targets for the treatment of breast cancer remains a curr |
Chicago | |
| Carbazole Derivatives as G9a Methyltransferase Inhibitors for Cancer Treatment and Autophagy Induction. |
G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation. |
Chicago, Oncologic, Reproductive, Respiratory, Therapeutic | |
| CAVE2 (TM) System |
Increasingly, the Nation’s computational science and engineering research communities work with international collaborators to tackle complex global problems. |
Graphics/Visualization/Image | |
| Cblb – A Therapeutic Agent to Prevent the Consequences of Sepsis |
Lung diseases, excluding lung cancer, caused an estimated 243,000 deaths in 2003. The market for anti-inflammatory drugs to treat diseases was approximately $31.1 billion in 2005 and is projected to increase to $47.8 billion in 2010.
Cblb is the first specific agent to prevent or ameliorate a common cause of acute lung injury. Few effective drugs are available for the treatment of the acute inflammatory response underlying the clinical manifestations of sepsis. |
Chicago, Circulatory, Infectious, NONE OF THESE, Reproductive, Respiratory, Urinary, Therapeutic | |
| Cellular detection of luminescence resonance energy transfer enabled by protein-targeted, lanthanide complexes |
Fluorescence resonance energy transfer (FRET) microscopy is used to image transient protein-protein interactions in living cells. In FRET, a donor fluorophore is excited by incident light, and the excited state energy from the donor is transferred to a nearby (< 10 nm) acceptor fluorophore. |
Chicago, Research Tools and Reagants | |
| Characterization of Ultra Thin (< 50 Å) Dielectric Films to Increase Chip Production Efficiency and Decrease Waste (MEPR-FTIR) |
Currently, FTIR is used to probe semiconductor wafers but cannot be used to probe the thinner dielec |
Chicago | |
| Charge Pump Power Converter |
This invention comprises a series of 7 patents and patent applications with various European and Asi |
Batteries and fuel cells, Chicago | |
| Chemical Dyes as Contrast Agents for Optical Coherence Tomography |
This invention utilizes chemical dye in optical coherence tomography (OCT) by altering the optical spectrum of incidence radiation. |
CT, Research tools, Urbana-Champaign, Diagnostic hardware/software/medical devices |
|
| Chemical Ligation |
Development of efficient chemical ligation methods for the attachment of small molecules to peptides and proteins, for joining two proteins, and for the attachment of oligosaccharides to peptides and proteins is an area of current research interest. Large glycopeptides or proteins are generally prepared from smaller fragments by convergent synthesis, and chemical ligation is a critical step in assembling large molecules from smaller building blocks. The efficiency of the chemical ligation depends on the permanency of the ligated bond. |
ALL OF THESE, ALL OF THESE, Chicago, Therapeutic | |
| Chronic pain therapy using transplanted autologous chromaffin-like cells |
Opioid
therapy is the cornerstone of pain management; however, opioids can lead to
negative health consequences including cognitive impairment, tolerance, drug
abuse, and addiction.Alternative approaches to treat pain include the use of
intrathecal pump implantation for opioid infusion and implanted stimulators for
electrical stimulation of the brain, spinal cord, and peripheral nerves.
Although such strategies can be effective, cost and invasiveness in addition to
potential serious complications limittheir application to a relatively small
patient population. |
Chicago | |
| CMOS compatible processes for Epitaxial CoSi2 formation in shallow junction semiconductor devices |
As semiconductor device scaling extends into the deep sub-micron regime, the criteria for a salicide process become more stringent. Of particular concern is the junction leakage current, which is a strong function of silicided contact quality. The necessity for epitaxial metal-silicides has become apparent for future generation ultra-shallow junction devices in order to provide uniform silicide-Si interface and preserve the junction integrity. |
Processes, Urbana-Champaign | |
| Co-Stimulation Augments the Proliferation of CD4+CD25+ Regulatory T-cells |
A sub-population of CD4+ T-cells that express CD25 has been identified for its crucial role in the physiological control of autoimmunity and is referred to CD4+CD25+ cells. These cells account for a small percentage of the normal CD4+ T-cells. The discovery of CD4+CD25+ cells has lead to a flurry of investigations to utilize these cells to control undesired responses of T-cells against beneficial foreign antigens. The current invention leverages CD4+CD25+ cells in a way that surpasses any prior art for tolerizing the immune system for specific antigen suppression. |
Chicago, Proteins, Genomics/proteomics | |
| Cobalt Precursors for Formation of Cobalt or Cobalt-Containing Material |
Chemical vapor deposition (CVD) of cobalt requires a cobalt precursor that can be easily vaporized, leaving high-purity cobalt on a surface while causing no surface damage. This newly developed technology covers the composition of new cobalt precursors and a method for producing high-quality cobalt (or cobalt-containing) films and powders using those precursors. |
Processes, Urbana-Champaign | |
| Coherent fiber continuum source centered at 1040nm by in situ transform-limited pulse compression |
This technology provides a method using standard,
inexpensive components and software, in an elegantly simple configuration, to generate
ultra-short laser pulses of a quality currently available only from complex,
costly systems, such as the Ti:Sapphire laser.
Ultra-short laser pulses, shorter than 10 - 15 femtoseconds, are used in
many applications including: multiphoton microscopy, coherent anti-Stokes Raman
spectroscopy, and femtochemistry. At
this time, such precision ultra-short pulse lasers are largely cost prohibitive
in many applications, relatively difficult and |
Microscopy, Urbana-Champaign | |
| Coil Inductor Assembly Method |
This technology-plastic deformation magnetic assembly (PDMA)-is an innovative, proven, patent-pending method for vertically assembling inexpensive, high-performance coil inductors that take up a small area on the chip and reduce noise due to substrate loss.
University researchers developed this novel assembly method for integrating coil inductors into radio frequency (RF) circuits. PDMA essentially stands the coil inductors vertically on end so that they take up far less space on the chip than planar inductors. |
MEMS Devices, Urbana-Champaign | |
| Colloidal Polymer Adsorbent for Removing Natural Organic Matter from Drinking Water Supplies |
This patent-pending purification technology offers a more environmentally friendly and economically competitive method for purifying drinking water supplies. |
Urbana-Champaign, Water | |
| Combination therapy targeting both GSK3 and CK2 for treatment of Alzheimer’s disease. |
Alzheimer's disease(AD) has been identified as a protein misfolding disease (proteopathy), caused by accumulation of abnormally folded A-beta and tau proteins in the brain. Amyloid beta (Aβ or Abeta) is a peptide of 39–43 amino acids that appear to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. The pathological mechanism by which Aβ causes neuronal dysfunction and death remains largely unknown. |
Chicago, Nervous, Neurologic, Therapeutic | |
| Commensal/ Food bacteria-based DNA vaccine and DNA vaccine-delivery system |
Existing delivery systems have many limitations related to efficiency and safety. Some of these techniques include the gene gun, high voltage electroporation, lipofection, infective viruses (i.e. retroviruses, herpes and adenoviruses) or bacteria. An ideal molecular delivery system should be safe, highly efficient, biocompatible, non-immunogenic, capable of protecting DNA/RNA/protein, and small in size. The majority of existing delivery systems are used for in vitro transfection and have low efficiencies (i.e. |
Chicago, Vaccines, Drug delivery, Research Tools and Reagants, Therapeutic | |
| Commutation technique for an ac-to-ac converter based on state machine control |
This invention is a technique that resolves current commutation challenges in various types of ac-ac switching power converters. It also applies to inverters and rectifiers with high-frequency links. Direct ac-ac converters such as matrix converters and cycloconverters benefit from the approach. This technology commutates load current without inserting dead-time into the switching sequence or using large inductors to limit shoot-through current. Both of these prior techniques intrinsically compromise a converter's performance and efficiency. |
Batteries and fuel cells, Urbana-Champaign | |
| Compounds that Selectively Induce Cancerous Cell Death in the G1 Phase of the Cell Cycle | ALL OF THESE, ALL OF THESE, Urbana-Champaign, Cell Biology, Gene expression, regulation and signal transduction, Anti-inflammatory, Marker, Molecular Biology, Drug Design, Drug targets, Proteins, Immunotherapy, Drug delivery, Genomics/proteomics, Sythesis and Analysis, Research Tools and Reagants, Therapeutic | ||
| Concept for qHNMR using GARP decoupling |
NMR spectroscopy is one of the principal techniques used to obtain physical, chemical, electronic and structural information about a molecule. It is the only technique that can provide detailed information on the exact three-dimensional structure of biological molecules in solution. Given the diversity of its applications, NMR spectroscopy has become, and will continue to remain, indispensable to the pharmaceutical and biotech industries. |
Chicago, NONE OF THESE, NONE OF THESE, Spectroscopy, Research Tools and Reagants | |
| Conductive, hydrophobic Nanofiber coating for smart textiles |
E-fabrics
are fabrics that incorporate electronics and circuitry into natural and
synthetic fibers. E-fabrics need to
maintain conductivity while being stretched and subjected to the same wear normal
fabric would experience. The UIC
inventors have created a nitrile rubber matrix with nanofiber fillers (metallic
or nonmetallic) formulated for spray application to surfaces. This spray can create elastic, conductive
coatings or printed circuits. The
invention is specifically formulated to be applied to synthetic fibers, such as
polyester, without loss of adhesi |
Chicago, Energy, Environmental Sciences and Materials |
|
| Continuous flow Nanoparticle Production through ultrasonic spray pyrolysis |
This invention is a method for the continuous production of semiconductor nanoparticles (i.e. quantum dots), nanostrucutured catalysts, nanostructured metals and metal oxides, and ceramic oxide nanoparticles using ultrasonically generated aerosols of high boiling point solvents. |
Processes, Urbana-Champaign | |
| Controlled-release Drug Delivery Through Precision Particle Fabrication |
This patent-pending technology can produce uniformly sized microparticles (5 to 500
μm) made from biocompatible, biodegradable polymers. These particles release the drugs they contain with an unprecedented level of control, enabling custom-designed drug release profiles and effectively managing the burst effect. Precision Particle Fabrication (PPF) uses acoustic excitation and/or flow-limited field-injection electrostatic spraying technologies to fabricate either uniformly sized micro- or nanoparticles of predefined, complex size distributions. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Drug delivery | |
| Copper Mediated Trifluoromethylation of Aryl Iodides |
The
trifluoromethyl group is found in many biologically active compounds and
pharmaceuticals. The utility of these groups is well established, but the
methods of incorporating them into aromatics compounds are limited. Traditionally,
trifluoromethyl groups are introduced into aromatic compounds by the reaction
of carboxylic acids with sulfur fluoride, or the fluorination of
trichloromethyl group with a reagent, but these are toxic and difficult to
handle. |
Organic, Urbana-Champaign | |
| Corn Pericarp Recovery Method for Dry Milling Process Increases Cost Efficiencies |
This technology is a flotation method for recovering corn coarse fiber (pericarp or bran) in the corn dry milling ethanol process (dry grind process). In the dry grind process, the pericarp is ground up with the rest of the kernel components and placed in the fermenter. The pericarp does not ferment and ultimately ends up in the low valued distillers dried grains with solubles (DDGS) after having taken up valuable space in the fermenter. |
Crops and Germplasm, Urbana-Champaign | |
| Crack Sensor | Chicago, Manufacturing and Construction | ||
| Crack Sensor |
The present UIC invention provides a new methodology to
measure large displacements in concrete structures. In general, structural
displacements and crack openings in civil structures are large and in the order
of a few millimeters or centimeters. Mechanical systems using springs and
magnetic transduction methods or other techniques are employed to measure large
displacements. |
Chicago | |
| Creating a New Type of Diode from Dissipative Quantum Dots |
A small electronic system, referred to as a quantum dot
(QD), possesses discrete energy levels, whose energy spacing can be much larger
than room temperature (Note that the term “quantum dot” is used in a very
general way: it simply describes an electronic system that possesses discrete
energy levels. As long as the electronic states of this quantum dot do not
interact with the outside environment (for example, they are not located on a substrate),
an electron located in one of these energy levels can in general not transition
to another level. |
Chicago, Engineering |
|
| Creating super-resolution images using standard photobleaching and blinking movies |
Current super-resolution microscopy techniques require special laser setups and fluorescent molecules (such as PALM and STORM) that allow the fluorophores to be turned on and off so that only a small number of fluorophores are turned on at any time. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Cell signaling | |
| Customizable microfluidic chips |
University researchers have developed two separate methods for the design and fabrication of customizable microfluidic chips. |
Urbana-Champaign | |
| Data Mining Software for Market Research |
The
inventor has developed sentiment analysis software that uses a corpus based
classification approach for text mining.
Various sources maintain that insights derived from text mining of user
generated feedback can provide substantial economic benefits to businesses looking
for competitive advantages. The proposed
software could be used as a stand-alone sentiment analysis system or added to
an existing text analytics system which needs sentiment analysis capabilities. |
Chicago | |
| Dereplication database and classification system for chemical compounds, specifically from the genus Actaea |
UIC Scientists have designed an automated chemical structure dereplication software capable of identifying the chemical structure of an unknown molecule from raw NMR data using dereplication and data mining principles. The dereplication tool provides information about chemical shifts of methyl groups within the triterpenoid family of molecules. This software provides a standardized model for naming the compounds based on the structure and variation to the methyl group location including members of the cycloartane triterpenes family. |
Chemistry and Physics, Chicago, Bioinformatics | |
| Dereplication database and classification system for chemical compounds, specifically from the genus Actaea |
UIC Scientists have designed an automated chemical structure dereplication software capable of identifying the chemical structure of an unknown molecule from raw NMR data using dereplication and data mining principles. The dereplication tool provides information about chemical shifts of methyl groups within the triterpenoid family of molecules. This software provides a standardized model for naming the compounds based on the structure and variation to the methyl group location including members of the cycloartane triterpenes family. |
Chemistry and Physics, Chicago, Bioinformatics | |
| Dereplication database and classification system for chemical compounds, specifically from the genus Actaea |
UIC Scientists have designed an automated chemical structure dereplication software capable of identifying the chemical structure of an unknown molecule from raw NMR data using dereplication and data mining principles. The dereplication tool provides information about chemical shifts of methyl groups within the triterpenoid family of molecules. This software provides a standardized model for naming the compounds based on the structure and variation to the methyl group location including members of the cycloartane triterpenes family. |
Chemistry and Physics, Chicago, Bioinformatics | |
| Dereplication database and classification system for chemical compounds, specifically from the genus Actaea |
UIC Scientists have designed an automated chemical structure dereplication software capable of identifying the chemical structure of an unknown molecule from raw NMR data using dereplication and data mining principles. The dereplication tool provides information about chemical shifts of methyl groups within the triterpenoid family of molecules. This software provides a standardized model for naming the compounds based on the structure and variation to the methyl group location including members of the cycloartane triterpenes family. |
Chemistry and Physics, Chicago, Bioinformatics | |
| Dereplication database and classification system for chemical compounds, specifically from the genus Actaea |
UIC Scientists have designed an automated chemical structure dereplication software capable of identifying the chemical structure of an unknown molecule from raw NMR data using dereplication and data mining principles. The dereplication tool provides information about chemical shifts of methyl groups within the triterpenoid family of molecules. This software provides a standardized model for naming the compounds based on the structure and variation to the methyl group location including members of the cycloartane triterpenes family. |
Chemistry and Physics, Chicago, Bioinformatics | |
| Dereplication database and classification system for chemical compounds, specifically from the genus Actaea |
UIC Scientists have designed an automated chemical structure dereplication software capable of identifying the chemical structure of an unknown molecule from raw NMR data using dereplication and data mining principles. The dereplication tool provides information about chemical shifts of methyl groups within the triterpenoid family of molecules. This software provides a standardized model for naming the compounds based on the structure and variation to the methyl group location including members of the cycloartane triterpenes family. |
Chicago, Molecular Modeling, Bioinformatics | |
| Desktop Simulated Medical Record Interface |
The
proposed invention is a secure web-based application using a |
Chicago | |
| Detecting and Correcting System Constants on an MR System |
A generalized technique for simultaneously characterizing an MRI system delay and all eddy currents associated with a physical gradient axis is proposed. |
||
| Detecting and Correcting System Constants on an MR System |
A generalized technique for simultaneously characterizing an MRI system delay and all eddy currents associated with a physical gradient axis is proposed. |
||
| Detecting and Correcting System Constants on an MR System |
A generalized technique for simultaneously characterizing an MRI system delay and all eddy currents associated with a physical gradient axis is proposed. |
||
| Detecting and Correcting System Constants on an MR System |
A generalized technique for simultaneously characterizing an MRI system delay and all eddy currents associated with a physical gradient axis is proposed. |
ALL OF THESE, ALL OF THESE, Chicago, MR, Diagnostic hardware/software/medical devices | |
| Detecting human activities using smartphones and maps |
In
ubiquitous and context aware computing, understanding the mobility of a client
from sensor data is an important area of research. The transportation mode,
such as stair, escalator, elevator, car, bus, aboveground train, or walk
denotes some characteristics of the mobile user’s context. With knowledge of a
traveler’s transportation mode, targeted and customized advertisements may be
sent to the traveler’s device. |
Applications |
|
| Detection and Prediction of Disordered Breathing Events Using a LAMSTAR Neural Network (NN) |
Currently,
the most common and effective treatment for obstructive sleep apnea (OSA) is
continuous positive airway pressure (CPAP). This involves blowing air into the
airway during sleep to maintain its patency. Existing auto-titrating CPAP
systems rely only on early detection of disordered breathing events. |
Chicago, Pulmonary, Respiratory, Therapeutic hardware/ software/medical devices | |
| Development of Nanoscale Neuromodulating Platforms for Vision Restoration |
The invention is a nanoscale molecular structure that can selectively attach to the extracellular fa |
Chicago, NONE OF THESE, Ocular, Biomaterial, Cell signaling, Research Tools and Reagants, Therapeutic hardware/ software/medical devices | |
| Device and Method for Screening Molecular Diversity For Agents Which Bind Macromolecules and Their Complexes |
UIC researchers have found a novel technology, comprising of a method and a device, for the identifi |
Assays, Chicago, Diagnostic biological tests/assays, Digestive, Gastrointestinal, NONE OF THESE, NONE OF THESE, Bioinformatics, Drug Design, Research Tools and Reagants, Therapeutic, Therapeutic hardware/ software/medical devices | |
| Diabetes ABCs |
A novel app that provides a visualization for health care providers and educators to use with patients. It will show values of A1c, blood pressure, and LDL-cholesterol relative to goals using a thermometer scale. |
Chicago, Educational/Research Tools | |
| Diagnostic and Potential Therapeutic Targets to Prevent Arrhythmia |
Heart disease is the number one cause of death in the United States, surpassing even cancer. The National Center for Chronic Disease Prevention and Health Promotion estimates that approximately 950,000 Americans die of cardiovascular diseases every year, accounting for more than 40 percent of all deaths. One form of cardiovascular disease, arrhythmia, is associated with very high levels of morbidity and mortality. Sudden arrhythmic death claims more than 300,000 lives each year.
Arrhythmia is defined as abnormal beating of the heart caused by various factors includ |
Chicago | |
| Differential MMSE Reception: New Algorithms Improve High-Capacity Wireless Communications |
This invention provides a new method of simultaneously addressing two major problems in high-capacity wireless communications: signal fading and interference. The technology consists of a new signal control algorithm that reformulates the minimum mean squared error (MMSE) criterion. Adaptive receivers for interference suppression based on the standard MMSE criterion fail over fading channels. |
Networking/Data Transmission, Urbana-Champaign | |
| Discovery of novel inhibitors of Pantothenate Synthetase using hierarchical screening | ALL OF THESE, Chicago, Infectious, Drug Design, Research Tools and Reagants | ||
| Dissolvable Films of Silk Fibroin for Ultrathin, Conformal Bio-Integrated Electronics |
Strategiesfor bio-integrated electronics must overcome the numerous challenges associatedwith the mismatch between the hard, planar surfaces of semiconductor wafers andthe soft, curvilinear tissues of biological systems. These differences between the surfaces leadto low fidelity coupling at the biotic/abiotic interface as well as limitedlong-term tissue health. Even extremelythin, flexible systems can only wrap around shapes with zero Gaussian curvature(such as developable surfaces such as cones and cylinders). |
ALL OF THESE, ALL OF THESE, Nervous, Neurologic, Urbana-Champaign, Invasive device, Therapeutic hardware/ software/medical devices | |
| DNA Sequence that Confers Aphid Resistance in Soybeans (Rag2) |
Soybean aphid
is an invasive insect pest that was first discovered in North America in 2000. Since
then, these aphids have become a significant pest in the soybean producing
regions of the northern USA and southern Canada. Currently, millions of acres
of fields are sprayed with insecticide each year, which is both costly and has
potential environmental implications. Researchers at the University of Illinois
and USDA – Agricultural Research Service have identified a gene that can confer
aphid resistance for soybeans. |
Crops and Germplasm, Urbana-Champaign | |
| DNA Sequence that Confers Aphids Resistance in Soybeans (Rag1) |
Soybean aphid
is an invasive insect pest that was first discovered in North America in 2000
and can have devastating effects on soy crops and yields. A new advance from
the University of Illinois Department of Crop Sciences allows for engineering
of aphid-resistant soybean cultivars. |
Crops and Germplasm | |
| DNA Sequencing Systems Using Nanoscale Field Effect Sensor Arrays |
This invention is a novel approach to performing DNA sequencing-by-synthesis methodology that is anticipated to make DNA sequencing routine, highly accurate and affordable. |
ALL OF THESE, ALL OF THESE, Assays, Diagnostic biological tests/assays, Urbana-Champaign | |
| Double Chambered Sequential Compression Device to Prevent or Heal Pressure Induced Ulcers |
Existing Sequential Compression Device’s (SCD) resolve Deep Vein Thrombosis (DVT) and Post-Thrombosis Syndrome (PTS) but are unable to prevent Heel Pressure Ulcer (HPU) from potentially developing as they do not prevent the heel from being pressed on mattress for long periods of time. Heel pads used to prevent HPU can rarely be used along with SCD as they interfere with each other. The Double Chamber SCD modifies the existing SCD by providing elevation to the leg (or rested limb) and thus prevents the conditions which cause HPU. |
Chicago, Circulatory, NONE OF THESE, Noninvasive device, Therapeutic hardware/ software/medical devices | |
| Drug discovery of anti-H5N1 and other influenza virus entry inhibitors |
H5N1, a highly pathogenic avian influenza virus, has become a new pandemic threat since it has rapid |
Chicago, Pulmonary, Respiratory, Drug Design, Antiviral, Research Tools and Reagants, Therapeutic | |
| Drug Discovery of Enoyl-Reductase (FabI) Inhibitors against F. Tularensis and Bacilllus anthracis in a Computational Approach |
Although Tularemia and Anthrax are rare according to the records in US, the diseases themselves are highly incapacitating to infected persons and have been used as biological weapons in the past. For the national security, the development of their specific antibiotics is particularly necessary. Scientists in Center for Pharmaceutical Biotechnology have found a lead compound based on a computational high-throughput screening targeting Francisella tularensis FabI.
|
Chicago, Circulatory, Infectious, Antibiotic | |
| Drug Treatment For Sleep Related Breathing Disorder | Chicago, Nervous, Neurologic, Pulmonary, Respiratory, Therapeutic | ||
| Drug treatment to increase stem cell population |
Market research indicates that neurodegenerative diseases are destined to become the next great health crusade over the next several decades. One of the approaches to this issue involves stem cells. Stem cells are unspecialized cells that have a unique ability to develop into any type of cell. They may potentially serve as an unlimited source of specialized cells including blood, liver, muscle, and bone cells. Patients with damaged cells due to neurological conditions may benefit from such research. |
Chicago, NONE OF THESE, NONE OF THESE, Ocular, Ophthalmalogical, Cell Biology, Research Tools and Reagants, Stem cells | |
| Dual Drug Entities for the Treatment of Alzheimer’s Disease |
The present UIC invention is a medical invention related to a new treatment modality for Alzheimer’s disease. Alzheimer’s disease is a neurodegenerative disease charac-terized by the presence of both amyloid plaques and neurofibrillary tangles. Oxidative stress in neuronal cells has also been implicated as a major contributory factor. Current therapeutic approaches towards Alzheimer’s are directed towards either targeting the prevention/ removal of amyloid plaques using PKC activators, or the management of oxidative stress using HDAC inhibitors. |
Chicago, Nervous, Neurologic, Therapeutic | |
| Early Extraction of Fetal Heart Sounds |
Non-invasive extraction of fetal ECG (fECG) is not possible except late in the pregnancy due to difficulties in separating the fECG signal and differentiating it from the maternal ECG (mECG). For effective treatment of fetal cardiac problems, it is important to obtain an early fECG. However, early in the pregnancy, the mother’s heartbeat is several thousand times stronger than the fetal heartbeat. This limits the ability of medical personnel to accurately examine the fetal heartbeat and detect any abnormalities. |
Assays, Chicago, Gender-specific disorders, NONE OF THESE | |
| Early Warning Hydraulic Pump Diagnostic System for Predicting and Preventing Pump Failures |
This new, reliable diagnostic system performs real-time pump health assessments that can predict pump failures prior to their occurrence thereby minimizing downtime for maintenance, improving safety and reliability of hydraulic pump systems, and reducing costs.
The technology can be easily integrated into new or existing hydraulic pumps without extensive modification. |
Agricultural Equipment, Urbana-Champaign | |
| Early Warning System for Aircraft Surface Contamination |
Ice formation and other surface contaminants frequently endanger aircraft by reducing their level of performance and maneuverability. This new sensing device improves the chances for aircraft pilots or autopilots to react, change flight controls to adjust to the situation, and avert accidents. Similar sensing systems exist; however, this system is a more efficient and better safeguard.
This system uses a sensor that measures the effects of the contaminant on the lifting surfaces, such as the wings of the aircraft, and relays this information to the pilot in real time. |
Aerospace, Urbana-Champaign | |
| Efficient Detection of Peroxide-Based Explosives |
TATP
(triacetone triperoxide) has emerged as an explosive of choice for terrorists
in recent years, because it is easy to produce, highly explosive, and hard to
detect. Some recent examples of TATP use are the Northwest Airlines Flight 253
attempted bombing (2009), the London bombings (2005), and the American Airlines
Flight 63 attempted bombing (2001). |
Sensors, Urbana-Champaign | |
| Electrophoresis as a method for improving hydrogel purification: a step toward therapeutic ready hydrogels |
Among the currently developed drugs, about 25% require encapsulation especially with drugs that are prone to side-effects which defines the role that drug delivery systems have in the therapeutic arena. Hydrogels are one type of delivery system that have been designed and used in the treatment of various clinical applications from wound healing to cancer. There are many synthetic and recombinant compositions that all aim to act as delivery systems for a variety of potential therapeutics including peptides, RNA, DNA and viruses. |
Chicago, Oncologic, Electrophoresis | |
| Engineered Pattern Release of Polydimethylsiloxane (PDMS) through Induced Surface Adhesion |
This technology is a new non-photolithographic method for preparing polymer resists that can be used in microfabrication as polymer resist molding methods.
The Adhesion Technique is an improvement on a previously known sealing method. The use of adhesion technique and the engineered release of the thin film form a support material using this novel design. |
Processes, Urbana-Champaign | |
| Enhanced DDGS |
A new process that uses a combination of sieving and elutriation/aspiration to separate traditional DDGS into two components: clear fiber and DDGS with enhanced or enriched characteristics such as low-fiber (LF), High Protein (HP) content. |
Agricultural Engineering, Urbana-Champaign |
|
| Enhancement of Immune Response to Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine by Interferon Alpha |
Porcine
reproductive and respiratory syndrome (PRRS) is a major problem for hog farmers
worldwide. PRRS is caused by a virus which leads to reproductive failure in
sows and respiratory problems in piglets and growing pigs. The PRRS virus
spreads rapidly, leading to large economic losses for farmers and overall lower
health for pigs. Currently, PRRS is controlled by inoculating pigs with
modified live virus which stimulates the immune system of pigs against the PRRS
virus. |
Life Sciences - Non-medicine, Urbana-Champaign |
|
| EphB1/Elk signaling regulates albumin transcytosis via caveolae in endothelial cells |
The present invention is related to a
targeted drug delivery system, and in particular, a method of delivering agents
to specific tissues utilizing the endothelial transcytosis mechanism. |
Chicago, Drug delivery | |
| Esophageal Stethoscope for Extraction of Discrete Heart Sounds from the Heart Sound |
According to the CDC, heart disease and stroke are the first and third leading causes of death in the United States, respectively. Public health measures, such as encouraging healthier lifestyles and increasing early detection and intervention have been significant in preventing heart disease and stroke for those who are healthy and in improving the health of people who have experienced these conditions. |
Circulatory, Diagnostic hardware/software/medical devices | |
| Estrogen Receptor alpha and beta promoters in pGL3 vectors |
Estrogen Receptor alpha and beta promoters in the luciferase reporter vector pGL3. |
Chicago, Cell Biology | |
| Evidence Based Treatment of Behavioral Symptoms of Dementia - Mobile App |
Researchers at the University of Illinois at Chicago have developed a downloadable digital application (App) that is designed to aid clinicians and dementia care professionals in behavioral management of dementia in older adults. This App is an evidence based treatment algorithm that is designed to be downloaded to iOS and Android devices as a portable aid to clinicians in determining appropriate treatment options for those affected by dementia. Specifically, the App takes the user through a series of questions based on the behavior of the patient in order to determine treatment options. |
Applications, Chicago | |
| Evidence for noradrenergic neuronal damage in experimental autoimmune encephalomyelitis (EAE) |
A demyelinating disease (DD) is any disease of the
nervous system in which the myelin sheath of neurons is damaged. DD of the
central nervous system such as Multiple Sclerosis(MS) , Optic Neuritis
typically have no cure. MS is an idiopathic disease of suspected autoimmune cause,
in which the body's immune response attacks a person's central nervous system,
leading to demyelination. It has a prevalence that ranges between 2 and 150 per
100,000.Treatments attempt to return function after an attack, prevent new
attacks, and prevent disability.
|
Chicago | |
| Expanding Umbilical Cord Blood Stem Cells to Allow for Adult Stem Cell Transplantation |
Hematopoietic Stem Cells (HSCs) are self-renewing, multi-potential cells mainly residing in bone marrow and are the progenitors of red blood cells, white blood cells and of the cells of the immune system. HSCs can also be isolated from umbilical cord blood and from the peripheral blood. HSCs comprise only a small fraction of bone marrow or umbilical cord blood cells, but are the critical element in HSC transplantation due to their ability to colonize bone marrow and to differentiate into the full complement of hematopoietic cells. |
Chicago, Stem cells | |
| Extendable intravenous catheter |
Intravenous catheters are used for administration of intravenous medications, fluids, and blood products, routinely in the emergency departments, hospitals, and other patient care areas. |
Cardiac, Chicago, Circulatory, Invasive device, Therapeutic hardware/ software/medical devices | |
| Extracellular Matrix Proteins Enhance Stromal Cell Adhesion |
Corneal transplantation is currently the most common form of organ transplant performed in the United States. |
Chicago, Ocular, Ophthalmalogical, Therapeutic |
|
| Fabrication of Microfluidic Systems and Components Using Light Initiated Polymerization |
The potential of microfluidics systems has been limited by cost. Now a new technology offers an innovative, cost-effective method for making and integrating fluidic microchannels. This proprietary method for ultra-rapid prototyping of microfluidic systems requiring fewer than 5 minutes from design to prototype uses liquid phase polymerization as an alternative to etching microchannels in silcone or glass. |
MEMS Devices, Urbana-Champaign | |
| Fiber optic spectroscopic digital imaging sensor for flame properties monitoring |
The proposed invention is novel system for monitoring flame properties using a fiber optic spectroscopic imaging sensor. |
Chicago, Sensors | |
| Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Composite Materials |
In the United States, 2.5 million orthopedic and plastic reconstructions, including bone, cartilage, tendon, ligament, and breast, are performed annually. Most bone repair procedures require a replacement structure to restore tissue function, including total substitutes (artificial joints), or tissue harvested from a second anatomic location of the same patient or from other patients and transplanted to the compromised area. |
Chicago, Dental, Skeletal, Biomaterial, Therapeutic hardware/ software/medical devices | |
| Fit and Strong! An award-winning, evidence-based program for older adults with osteoarthritis |
Osteoarthritis is one of the oldest and most common types of arthritis. When cartilage breaks down in the joints, it causes bones to rub against each other, resulting in serious pain and a severe loss
of movement for the patient. The biological cause of the condition is unknown, but the incidence of osteoarthritis increases with age. Osteoarthritis is estimated to affect over 20 million Americans, with most of those sufferers over the age of 45. Women are more likely than men to develop osteoarthritis after reaching the age of 50. Currently, there is no preve |
Chicago, Rheumatologic, Skeletal, Therapeutic | |
| Flared and Tapered Rib Waveguide Laser |
This invention increases a narrow stripe laser's power while maintaining its single mode nature by making the laser wider. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Flaw Tolerant Oxide Ceramic Composites |
This set of technologies take up the problems associated with ceramics in oxidizing environments. By strengthening materials and slowing the growth of cracks it is possible to produce flaw tolerant oxide ceramic composites. |
Composites, Urbana-Champaign | |
| Flexible Sensory Skin |
These technologies include three inventions that can work independently or that can be integrated to address problems with sensing and monitoring in a wide variety of industries, including military, medical and robotics. Each of the three inventions confronts a specific set of problems:
Artificial Hair Cell Sensor is a method for designing and fabricating arrayed artificial cilia-type micro-sensors in flexible substrates. |
Non-MEMS Devices, Urbana-Champaign | |
| Form and function of bone marrow derived from endothelial progenitor cells, their potential use in cell-based therapies for regenerative and reparative medicine, and as an aid for tumor cell killing and drug screening |
Cell therapy technologies and methods have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. The inventors have identified a way to use bone marrow derived endothelial progenitor cells for use in cell-based therapy ranging from reparative medicine to drug screening. |
Chicago, NONE OF THESE, Skeletal, Drug delivery, Stem cells | |
| Foxm1b siRNA to Inhibit Tumor Cell Proliferation |
Hepatocellular Carcinoma (HCC), also known as primary liver cancer or hepatoma, is a cancer that ari |
Chicago, Digestive, Gastrointestinal, Oncologic, Gene and Cell Therapy, Therapeutic | |
| Frequency Domain Dynamic Light Scattering (FD-DLS) and Fourier Transform Angular Light Scattering (FT-ALS) |
The Frequency Domain Dynamic Light Scattering (FD-DLS) is a new methodology that facilitates study of dynamics in arbitrarily scattering samples. Dynamic light scattering (DLS) measures the intensity of light scattered by particles in the sample over a broad range of temporal scales. DLS instruments obtain a correlation factor from the intensity versus time profile for situations where light scatters no more than once in the medium. |
Microscopy, Urbana-Champaign | |
| FRET Based High-Throughput Screening |
Advanced molecular imaging tools combinedwith investigative tools like biochemical and cell based assays have thepotential to unravel complex molecular processes. These tools combined withhigh throughput screening can significantly impact diagnostics for cancerscreening and accelerate drug discovery. The present inventions are two new FluorescenceResonance Energy Transfer (FRET) biosensor pairs, one composed of two newcolors, mOrange2 and mCherry and the other composed of a modified high-sensitiveECFP/YPet pair that can significantly enhance the dynamic range of a variety ofbiosensors. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Molecular Biology, Genomics/proteomics |
|
| Fuel Cell Separator Plate Having Controlled Fiber Orientation and |
This technology is both a new fuel cell separator plate made of robust composite materials and a method of manufacturing said separator plate. |
Urbana-Champaign | |
| Full length and truncated HSD17B7 promoter in pGL3 |
Full length and truncated HSD17B7 promoter in pGL3, a luciferase reporter vector. |
Chicago, Cell Biology | |
| Fully Optically Controlled Heterojunction Power Semiconductor Device For Fast Repetitive Switching |
Switches are possibly the most elementary devices in the field of electronics. A switch controls the flow of current in a circuit such that either the current flows at a value determined by the other components in series with it, or does not flow at all, as the case may be. A switch has it's own parameters that determine how fast it can switch from open to closed, or how rapidly it can interrupt the flow of current once it is has been opened. |
Chicago | |
| Gamma secretase regulates stem cell proliferation and cell fate determination |
Alzheimer's is a degenerative and terminal disease for which there is no known cure. The cause and progression of Alzheimer's disease is not well understood. |
Chicago, Nervous, Neurologic, Stem cells |
|
| Gas Purification Device with Liquefaction of Dilute Gas Components |
Many manufacturing processes currently emit large quantities of gas effluent into the atmosphere or dispose of by techniques such as thermal oxidation or bio-filtration (which both consume auxiliary fuel and produce CO2). These are usually carrier gases that contain dilute concentrations of organic gas (contaminants).
This invention discloses a new device process for separating dilute gas(es) (e.g. organic gases) from gas streams for reuse as a liquid or other useful purposes (e.g. auxiliary fuel or chemical manufacturing). |
Environmental Testing and Remediation, Urbana-Champaign | |
| Gateable Nanofluidic Interconnects for Three-Dimensional Microfluidic Architectures: “Intellipore” |
The Intellipore technology is a membrane system and method for creating complex, three-dimensional microfluidic devices with improved interconnect functionality. |
MEMS Devices, Urbana-Champaign | |
| Gene Cluster Capable of Enabling the Biosynthesis of the Antimicrobial Compound, Rhizocticin in Bacillus subtilis |
Phosphonic and phosphinic acids are bioreactive compounds that have been used as antibiotics, antifungal agents, antimalarial drugs, and herbicides. Rhizocticins are naturally occurring phosphonates produced by Bacillus subtilus that have antifungal properties and interfere with the biosynthesis of the amino acid threonine. By varying the N-terminal amino acid group in the rhizocticin compound, it i |
Infectious, NONE OF THESE, Urbana-Champaign, Antifungal, Therapeutic | |
| Genes for the Biosynthesis of Plantazolicin, a Molecule Effective in Killing Bacillus Anthracis |
Anthrax disease, caused the by the bacterium Bacillus anthracis, is a major bioterrorism threat. Currently, B. anthracis infections are treated with various broad-spectrum antibiotics. Antibiotic treatment must be effective at eliminating all B. anthracis, which often requires over 60 days of antibiotic treatment. Consequently, the current method of treatment increases the dangers of multi-drug resistance. |
ALL OF THESE, Urbana-Champaign, Antibiotic, Therapeutic | |
| Genetic Assay for Predicting Risk of Esophageal Cancer and a Proteomic Biomarker Assay to Monitor Esophageal Cancer Progression |
Esophageal
Adenocarcinoma (EAC) and squamous cell carcinoma (SCC) are two major
histological types of esophageal cancer.
Incidence of EAC has rapidly increased in America, with a nearly 5-fold
increase in Caucasian males. Factors
that attribute to SCC prevalence appear to vary depending on geographic
region. SCC has higher prevalence in
central Asia, southern Africa, and some areas of China; nutritional
deficiencies, intake of pickled vegetables, nitrosamine-rich or mycotoxin-contaminated
foods, and low socioeconomic status may be a factor. In Europe and Nor |
Chicago, Diagnostic biological tests/assays, Digestive, Oncologic, Immunoassay | |
| Genetic Screening Method for Selecting Genetically Elite Dairy Cattle |
Currently, it takes several years to gather reliable data for selecting genetically superior dairy cows or bulls for use in breeding programs using traditional methods. |
Urbana-Champaign, DNA/RNA sequencing, Genomics/proteomics |
|
| Handheld Heavy Metal Testing Device |
This
inexpensive and user friendly heavy metal testing device will benefit
environmental scientists and medical professionals. The technology measures a change in energy
resulting from aptamer folding in response to certain heavy metals. This measurement occurs in a handheld testing
device. |
Chicago | |
| Hearing-Aid Device and System |
This suite of technologies enhances hearing aid sensitivity and usability. Improved algorithms and microphone configuration innovation provide better signal processing and response. |
Assistive device, Auditory, Urbana-Champaign | |
| High Performance Sensor Boards for Structural Health Monitoring |
Civil
infrastructure is the foundation of our society and has a widespread impact on
the quality of our daily lives.
Monitoring the safety and functionality of the world’s buildings,
bridges, and lifeline systems, is critical to improving maintenance practices,
minimizing the cost associated with repair and ultimately improving public
safety. Structural health monitoring
(SHM) systems provide a way for engineers to determine the overall health of a
given structure. SHM systems have the
ability to detect real-time damage or potential failure due to outside events,
|
Civil, Mechanical and Industrial |
|
| High Strength Carbon Nanofibers with Modulated Surfaces |
Carbon fiber
technology is predominantly focused on microfibers in the range of X to Yum. Such fibers have been optimized heavily over
the past decades and are now used ubiquitously.
Carbon nanofibers on the other hand are a new idea and are currently
fairly crude, relatively short, unaligned, relatively impure, and necessarily smooth
thereby limiting possible applications. The
possibilities for carbon nanofibers are very diverse as they have the potential
to be used in any conventional microfiber application but can be used in
smaller laminar applications with dra |
Micro/nano scale (non-electronic), Urbana-Champaign | |
| High-Resolution Electrohydrodynamic Jet Printing for Printed Electronics |
Electrohydrodynamic jet printing has been largely ignored in the high resolution graphics and electronics fabrication industries because previous methods used broad and blunt nozzles that did not prov |
Urbana-Champaign | |
| High-temperature catalytic fuel reformation structure |
This micro-scale hydrogen reforming structure achieves the isolation of pure hydrogen gas from mainstream hydrocarbon fuel sources such as gasoline, diesel fuel or JP-8 for use in preexisting fuel cel |
Urbana-Champaign | |
| Higher efficiency Ca3Co4O9 thin film material for high-temperature thermo-electric energy generation |
Researchers
from the University of Illinois at Chicago and from the University of Alabama
at Tuscaloosa have discovered a method to improve the thermoelectric properties
of a Ca3Co4O9 thin film material
by 50% at room-temperature. An
improvement in high temperature waste-heat conversion into electrical energy is
valuable for industrial processes such as auxiliary power generation, solar
cells, or power plants. |
||
| Highly Reflective Interface For Distributed Bragg Reflectors |
Distributed Bragg Reflectors (DBRs) are a fundamental component of optical devices requiring an optical gain, such as various types of semiconductor lasers. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Histone acetyl transferases (HATs) activators and histone deacetylases inhibitors (HDACs) are novel therapeutic targets for alcoholism treatment |
Results
of the inventor’s study suggest that decreased histone acetylation due to
decreased activity of histone acetyltransferases (HATs) in the amygdala during
alcohol withdrawal may be associated with withdrawal symptoms such as anxiety. Also, acute ethanol exposure may produce
anxiolytic effects because of its capacity to increase histone acetylation via
increasing the levels of CREB binding protein recruitment. Increased CREB activity increases HATs
activity or inhibits the histone deacetylases (HDACs) activity in the amygdala.
Thus, HATs actvators or HDACs inhibitors |
ALL OF THESE, Chicago, NONE OF THESE, Therapeutic | |
| Homing Endoneucleases Selection System |
Researchers in the bioengineering department at the University of Illinois have developed a highly sensitive in vivo selection method for directed evolution of homing endonucleases.
The Zhao Lab has |
Dermatologic, Diagnostic biological tests/assays, Skeletal, Urbana-Champaign, Expression and purification, Immunoassay, Drug Design, Research Tools and Reagants | |
| HRQOL ( Health Related Quality of Life) Survey for patients with Systemic Lupus Erythematosus (SLE) |
UIC inventor has created a questionnaire, gathered data and used it to generate a Health Related Quality of Life (HRQOL) index for patients with Systemic Lupus Erythematosus (SLE) a debilitating autoi |
||
| HRQOL (Health Related Quality of Life) Survey for patients with Systemic Lupus Erythematosus (SLE) |
UIC inventor has
created a questionnaire, gathered data and used it to generate a Health Related
Quality of Life (HRQOL) index for patients with Systemic Lupus Erythematosus
(SLE) a debilitating autoimmune disease. Currently available generic measures
for HRQOL lack important domains that are particularly important in SLE
patients, such as sleep, fatigue and emotional intimacy. Though it would be
more appropriate to use a SLE specific HRQOL as a health outcome measure, none
is available for use in the US.
The Lupus QoL is such an instrument.
|
Chicago | |
| HSD17B7 Knockout Construct |
HSD17B7 construct for the generation of HSD17B7 knockout mice. |
Chicago, Cellular Engineering | |
| Human Carboxypeptidase D (CPD) Rabbit Polyclonal Antiserum |
Carboxypeptidase
D (aka: CPD, Metallocarboxypeptidase D, gp180), the human homolog of duck
gp180, is a member of the regulatory B-type carboxypeptidase family. Carboxypeptidases perform a wide variety of roles, ranging from food digestion
to the selective biosynthesis of hormones and neuropeptides. |
Chicago | |
| Human Carboxypeptidase D (CPD) Rabbit Polyclonal Antiserum |
Carboxypeptidase
D (aka: CPD, Metallocarboxypeptidase D, gp180), the human homolog of duck
gp180, is a member of the regulatory B-type carboxypeptidase family. Carboxypeptidases
perform a wide variety of roles, ranging from food digestion to the selective
biosynthesis of hormones and neuropeptides. |
Chicago | |
| Hybrid Modulation of Multiphase Converter |
This invention is a multiphase hybrid modulation scheme for the
operation of an isolated High Frequency and High Power Direct Power Conversion
(DPC) inverter. The invention is unique because it eliminates the Low Pass
Filter found in traditional inverters. Currently, conventional converters
include a diode rectifier stage which is followed by the Low Pass Filter and a
Voltage Source Inverter, (VSI) at the end. |
Chicago | |
| Hybrid Plasma-Semiconductor Transistors |
Plasma-based electronic devices assumed a significant role in communications and d |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Hybrid Semiconductor 3D Nanoscale Patterning Method using Superionic Solid State Stamping (S4) and Metal Assisted Etching (MacEtch) |
Various high aspect ratio semiconductor 3D nanostructures have begun to have profound effect on the design and performances of many types of devices, including batteries, solar cells, detectors and thermoelectrical systems. Photolithography is typically used for the fabrication of these nanostructures, which is an extremely expensive technique, especially for large area applications. |
Processes, Urbana-Champaign | |
| Hydrophilic Polymer Conjugated Lipids for Peptide and Protein Folding Disorders |
Treatment and control of peptide and protein folding disorders like Alzheimer’s disease remains a perplexing medical problem due to a poor understanding of the disease pathogenesis. Biochemical and genetic studies have implicated extracellular neuritic plaques formed from an aggregated hydrophobic peptide, beta amyloid (Aβ) as a major factor involved in the pathogenesis of AD. Beta amyloids are formed by cleavage of APP (Amyloid precursor protein) by the action of the enzyme secretase in the transmembrane region of the cell bilayer. |
Chicago, Nervous, Neurologic, Drug delivery | |
| Identification and Analysis of Genes Necessary for the Biosynthesis of the Phosphonate Antibiotic Dehydrophos from Streptomyces luidus |
Bacterialresistance to antibiotics is a growing problem. Phophonic and phosphinic acids are compounds with a carbon-phosphorusbond with P in the reduced form. They sharestructural similarity with phosphate esters and carboxyalte-containingcompounds which are ubiquitous metabolites in cellular biology, making themless toxic to the host organism. Inaddition, because these compounds exist in a reduced form, these compounds arehighly resistant to hydrolysis and enzymatic cleavage, making them morestable. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Antibiotic, Therapeutic |
|
| Identification of 12-MER Novel Peptides that blocks herpes simplex virus type-1 entry into primary human cell culture models |
Currently there are no vaccines or treatments that prevent Herpers Simplex Virus-1 (HSV-1). The inventor has identified specific peptides to heparan sulfate that could possibly be a prophylactic or therapeutic agent against Herpes infection. The peptide blocks Herpes Simplex Virus –1 from entering cells. |
Chicago, NONE OF THESE, NONE OF THESE, Gene and Cell Therapy, Therapeutic | |
| Identification of a pseudogene that is only expressed in human cancer cells and tissues |
The present invention is a medical invention related to a novel diagnostic marker for cancer. In particular, it relates to studies investigating the expression profile of a pseudo MLCK gene. Myosin-light-chain kinase (MLCK) is a serine/threonine-specific protein kinase that phosphorylates the regulatory light chain of myosin II. It is of critical importance in regulating cytoskeletal dynamics by increasing myosin-actin crossbridge. |
ALL OF THESE, Chicago, Oncologic, Gene expression, regulation and signal transduction, Genomics/proteomics | |
| Identification of Serum Amyloid A as an Endogenous Ligand for Toll-Like Receptor 2: Composition and Method for Detection |
In 2010, the market for anti-inflammatory
therapeutics is projected to exceed $40 billion at an average annual growth
rate of just over 10%. The market for
anti-inflammatory therapeutics for Rheumatoid Arthritis alone exceeds $12
billion per year. Scientists at the
university of Illinois at Chicago have discovered a novel therapeutic target
for treatment of these conditions. |
Cardiac, Chicago, Circulatory, Server, Immunotherapy, Drug delivery, Therapeutic | |
| Identifying the correct targets for dimethylfumarate to be used in the prognosis/diagnosis for MS disease severity, relapses, or remissions |
Dimethylfumarate
(DMF) is a drug with targets that are not well known. The inventor has
re-addressed the question of which protein(s) are targeted by DMF in the brain.
In astroglial cells, several proteins were identified which showed modification
on a cysteine residue. This can be used to determine other drugs that might
similarly modify those target proteins in vitro and in vivo. |
||
| ImageGrouper |
The technology is a software-based Graphical User Interface (GUI) that makes Content-Based Image Retrieval (CBIR) effective and easy to use. The software is a front-end user interface that can work on any underlying CBIR system. |
Graphics/Visualization/Image, Urbana-Champaign | |
| IMPACT Open-Source Compiler Efficiently Integrates Instruction-Level Parallelism |
The OpenIMPACT C-compiler incorporates instruction-level parallelism and generates C code for highly parallel microprocessors with twice the efficiency of existing open source compilers. It is designed to produce code for the newest state-of-the-art 64-bit processors and is freely available as an open-source program.
IMPACT has been used for nearly five years by leading microprocessor manufacturers for both microprocessor design and architectural evaluation. |
Systems, Urbana-Champaign |
|
| Improved Ion-Implanted pn Junctions in Semiconductors |
The invention improves the process of ion implantation and annealing, which is used to introduce dopants into a semiconductor to make pn junctions. The improvements control the motion of bulk semiconductor defects such as interstitial atoms through control of surface chemistry. This leads to a reduction of the depth and electrical resistance of the pn junction. |
Processes, Urbana-Champaign | |
| Improved Lipid-based Formulations of VIP/Secretin/Glucagon Family of Peptides to Treat Autism |
Autism is a psychiatric disorder, characterized by impairment in language, social communication, soc |
Chicago, Drug delivery | |
| Improved Raman Spectroscopic Analysis for Grain Composition |
Grain
breeders and dealers rely heavily on the compositional properties of many
different types of grain, including: soybeans, corn, rice, and wheat etc. The most common variables assessed for
commercial and nutritive properties of grains are oil and protein content, both
of which are highly variable, with values ranging from 20 – 60%. |
Crops and Germplasm, Urbana-Champaign | |
| Improving Bonding Properties of Surgical Glues for Cartilage Repair Using Liquid Crystal Matrices |
This technology offers an improved approach to repairing damaged articular cartilage using traditional bonding adhesives or surgical glues. |
Urbana-Champaign | |
| Improving the Cycle Time of Semiconductor Manufacturing |
This technology is an algorithm used for scheduling semiconductor wafer fabrication in multiproduct manufacturing plants. |
Business Software, Urbana-Champaign | |
| Inexpensive Refractometer Measures Fluid Concentration in Real Time |
This versatile and highly efficient refractometer determines the concentration of a fluid by measuring in real time the index of refraction of a fluid. |
Environmental Testing and Remediation, Urbana-Champaign |
|
| Infrared Microspectroscopy for Intact Fibers |
This
technology uses mathematical principles to correct for spectral distortions in
concert with a novel device capable of holding an individual fiber in tension
to thereby permit Infrared analysis of individual fibers. |
Microscopy | |
| Injectable System for Controlled Drug Delivery |
This technology provides an effective means of control release kinetics for pharmaceuticals. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Molecular Biology, Nucleic acid manipulation, Genomics/proteomics, Research Tools and Reagants | |
| Innovative and Versatile System for Measurement of Thickness, Uniformity, Delamination, and Integrity of In Situ Thin Films |
This technology is a new method for measuring the thickness and integrity of thin films (nanometer to micron thickness), primarily those deposited on semiconductor substrates, although it is broadly applicable to many material systems. It provides direct measurements, is relatively inexpensive, and can be implemented inline with an existing process. An invaluable series of applications exist for determination of film uniformity, extent of film lamination, and defect detection. |
Processes, Urbana-Champaign | |
| Innovative Computational Techniques for Identification of Novel T-cell Epitopes |
Disease associated proteins are broken down by the cellular proteolytic machinery. Antigen-specific |
ALL OF THESE, Chicago, Infectious, NONE OF THESE, NONE OF THESE, Disease Model, Research Tools and Reagants |
|
| Innovative fuel and new catalyst ink |
An innovative, formic acid fuel mixture enhanced by a safer and more efficient catalyst yields higher currents and superior performance in portable fuel cells. |
Renewable Fuels, Urbana-Champaign | |
| Integrated Lightweight Disaster Shelter (ILDS) |
Natural and political disasters leave hundreds of thousands of people without adequate shelter at any given time throughout the world. Current solutions administered by governments and aid agencies consist largely of tents and similar temporary shelters. These shelters, while inexpensive and easily transported, are neither durable, resistant to the elements, nor do they address the needs of clean water, electricity, disease and lighting. |
Civil, Mechanical and Industrial, Urbana-Champaign |
|
| Integrated Portable Pneumatically Powered Ankle-Foot Orthosis |
Below the knee muscle weakness, defined by weak
dorsiflexor (shin) or plantarflexor (calf) muscle groups, can result from a
variety of physical impairments or congenital abnormalities. Stroke, spinal
cord injuries, polio and multiple sclerosis are among some of the physical injuries
and congenital defects responsible for the condition. The largest complication
from below the knee muscle weakness is abnormal gait, which when compensated
for can lead to further complications in other muscles and joints. |
Muscular, Nervous, Neurologic, Skeletal, Urbana-Champaign, Noninvasive device, Therapeutic hardware/ software/medical devices | |
| IntelliBadge (TM) |
For the first time, IntelliBadge combines Radio Frequency ID technology with data management tools and real-time graphical visualizations to produce highly usable information about a person's movement |
Security, Urbana-Champaign | |
| Interference of TANK binding kinase 1 mediated antiviral response by virulence factor of herpes simplex virus 1 |
Herpes simplex virus 1 and 2 are two species of the herpes virus family that cause infections in humans. All viruses in the herpes family produce life-long infections. The proposed technology is a system that was created for developing vaccines and antiviral drugs for HSV-1 and HSV-2. Also, can be used to develop inhibitors of TBK1, a kinase required for proliferation and survival of cancers cells. |
ALL OF THESE, ALL OF THESE, Chicago, Vaccines, Research Tools and Reagants, Therapeutic | |
| Interferometric Synthetic Aperture Microscopy (ISAM) Using Partially Coherent Light Source |
Interferometric Synthetic Aperture Microscopy (ISAM) (TF06039) is a method of tomographic optical microscopy that brings the power of computed imaging and inverse scattering together with interfero |
ALL OF THESE, Autoimmune, Cardiac, Infectious, Neurologic, Oncologic, Pain, Pulmonary, Urbana-Champaign, Cell Biology, Imaging, Cell signaling, Diagnostic hardware/software/medical devices, Drug targets, Drug delivery, Research Tools and Reagants | |
| Interferon-Gamma Activation of Mesenchymal Stem Cells for Treatment and Prevention of Graft versus Host Disease |
Mesenchymal Stem Cells (MSC) can be manipulated to
facilitate organ repair and regeneration and manipulate the individual’s immune
system. Their ability to accomplish both of these tasks is dependent on their
state of activation. The UIC inventors have discovered a new method to activate
these stem cells and transform them so that they can provide more effective
regeneration as well as more effective control of damaging immune system
processes. |
Chicago, NONE OF THESE, NONE OF THESE, Immunotherapy, Stem cells, Therapeutic | |
| Inverse scattering for broadband scanning near-field microscopy |
The development of near-field scanning optical microscopy (NSOT) has been driven by the need for an imaging technique that retains the various contrast mechanisms afforded by optical microscopy methods while attaining spatial resolution beyond the classical optical diffraction limit.
NSOT, as an extension of near-field scanning optical microscopy (NSOM), amounts to inverting the scattering data collected by the NSOM and reconstructing the sample, instead of taking the raw data as an image of the sample.
|
Microscopy, Urbana-Champaign | |
| Ionizable Isotopic Labeling Reagents for Relative Quantification |
Liquid chromatography/mass spectrometry (LC/MS) is increasingly being used for metabolic analysis due in part to its widespread availability and compatibility with biological samples. This invention provides ionizable, isotopic labeling reagents and labeling reaction products, answering the current need for relative quantification using mass spectrometry.
|
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Spectroscopy, Research Tools and Reagants | |
| ISAC Technology |
Proven to significantly reduce reflection cracking in asphalt concrete (AC), the Interlayer Stress-Absorbing Composite (ISAC) technology is available for licensing by commercial companies.
Developed at the University of Illinois at Urbana-Champaign, ISAC is a three-layer composite that isolates the AC overlay from the pavement beneath it. Typical 2- to 3-inch thick AC overlays are susceptible to reflection cracking that is, propagation of cracks in the underlying pavement through the overlays. |
Highways and Roads, Urbana-Champaign | |
| JARID1A : a Novel Oncology Therapeutic Target |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed
nuclear protein. JARID1A binds to the retinoblastoma protein (RB) variants that
modulate cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed
nuclear protein. JARID1A binds to the retinoblastoma protein (RB) variants that
modulate cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
|
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed
nuclear protein. JARID1A binds to the retinoblastoma protein (RB) variants that
modulate cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed nuclear
protein. JARID1A binds to the retinoblastoma protein variants that modulate
cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed
nuclear protein. JARID1A binds to the retinoblastoma protein variants that modulate
cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed
nuclear protein. JARID1A binds to the retinoblastoma protein variants that modulate
cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed nuclear
protein. JARID1A binds to the retinoblastoma protein variants that modulate
cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| JARID1A : a Novel Oncology Therapeutic Target. |
Many cancers can be attributed to alterations and
mutations in tumor suppressor proteins. JARID1A (Jumonji, AT-rich interactive
domain 1A) also recognized as RBP2 and RBBP2 is a ubiquitously expressed
nuclear protein. JARID1A binds to the retinoblastoma protein (RB) variants that
modulate cellular transcription and molecular proliferation/differentiation. JARID1A has also been shown to interact with
rhombotin-2, a protein implicated in T-cell mediated leukemia.
JARID1B also recognized as PLU-1 has been shown to
block terminal differentiation altering cell fate. |
Chicago | |
| Jones Phase Microscopy and White Light Quantitative Phase Microscope (PC++) |
The phase contrast microscope is a vital instrument in biological and medical research; it facilitates the observation of living cells by using spatial light modulation to enhance the intrinsic contrast of transparent and colorless components in a cell. It can reveal cell structure without the need of contrast agents. However, the information obtained is only qualitative.
|
Microscopy, Urbana-Champaign | |
| L1 Adaptive Control for Robust Adaptive Control Systems with Performance Guarantees |
In flight control and other critical control systems, robust control is often augmented by gain scheduling to provide slowly adaptive robust behavior across varying operating conditions. Even with the benefit of gain scheduling, however, robust control is unable to provide performance guarantees under conditions outside the preconfigured set of parameters. Furthermore, because developing a gain-scheduled controller requires developing and linking several independent controllers, the development process is |
Aerospace, Urbana-Champaign | |
| Landscape Green Infrastructure Design (L-GrID) Model, a computer model for stormwater management |
In the US, there is a growing interest in the adoption of green infrastructure for stormwater management. This trend emerges from the increasing awareness that the growing area of paved surfaces due to urbanization has put increasing pressure on stormwater management facilities. As a result, there is a higher frequency of combined sewer outflows, floods and the exposure of residents and habitat to polluted water. |
Chicago | |
| Laulimalide-derived Potent Microtubule Stabilizing Agent |
Amphidinolides, a family of natural compounds that have shown promise as powerful anti-tumor agents, |
ALL OF THESE, Chicago, Oncologic, Therapeutic |
|
| Legislative Bill Tracking System |
Over the last
decade, every state and many counties, cities, school districts, and other
legislative and quasi-legislative bodies have published websites providing
up-to-date information on the debates, drafts, and motions of their legislative
processes.
It is
essential for an organization trying to monitor legislation to keep current on
the bills and motions moving through these legislative processes. |
Business Software, Urbana-Champaign | |
| Licensed March 28 2013 -----Treatment Of Carcinoma With A DNA-Based Vaccine Enriched For Cells That Induce Cancer Immunity - A New Vaccine Strategy |
According to the American Cancer Society, cancer is recognized as the second leading cause of death worldwide and accounts for over 20% of all deaths in the United States. Cancer develops when the balance between cell proliferation and cell death is disrupted, and the ensuing aberrant proliferation leads to tumor growth. While no cure for cancer exists to date, new treatment approaches using therapeutic vaccines offer a promising approach in the care of cancer patients. Ongoing studies involving the use of cellular vaccines in cancer therapy are currently being conducted worldwide. |
Chicago | |
| Light Emitting Transistor and Laser |
This invention is the world's first light emitting transistor. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Lipid Based Formulations of drugs for cardiovascular disease |
There are a limited number of marketed products to
treat symptomatic arrhythmias. Intravenous amiodarone is the drug of the choice
for life-threatenining arrhythmias such as ventricular tachycardia or
ventricular fibrillation and is sometimes (unapproved) used for supraventricular
tachycardias such as atrial fibrillation. However, it is poorly water soluble and current commerciallyavailable
formulations of intravenous amiadarone have serious side effects due to their
vehicles. |
Chicago | |
| Lipid Drug Delivery System for Cancer Therapeutics | ALL OF THESE, ALL OF THESE, Urbana-Champaign, Drug delivery | ||
| Long-Range Energy Transfer via Quenching Surfaces for the Detection of Biomolecular Binding and Unbinding |
This technology is a rapid, simple and sensitive method for detecting the binding or unbinding of biomolecules using a silicon wafer.
|
Urbana-Champaign | |
| Low Power, High Performance Circuits for Multi-GHz Systems |
This technology is a suite of four inventions relating to microelectronic logic circuits and the reduction of power and/or time requirements. The suite comprises: (1) parallel dynamic logic (PDL) and speed-enhanced skewed static logic (SSS); (2) skewed static logic (S2L) with topology-dependent dual threshold voltage (Vt); (3) reduced swing-clock double-edge triggered flip-flop; and, (4) low-power, small-area, small jitter, delayed lock-loop (DLL)-based clock generator.
Collectively, these technologies serve to reduce power consumption and/or enhance performance. |
Electronics, Urbana-Champaign |
|
| Low-cost Parylene Thickness Sensor for More Accurate Deposition Systems |
This simple, inexpensive sensor detects the end-point thickness during parylene deposition with greater accuracy than conventional methods. It reduces production costs and enables the use of parylene coatings in applications that require a higher precision of thickness than is currently available. This disposable sensor is fabricated using a low-cost micromachining technology and can be easily implemented in commercial parylene deposition systems. Use of the sensor requires only the replacement of a viewport by a new flange with electrical feedthroughs and mechanical supports. |
Sensors, Urbana-Champaign | |
| Lower Cost Pump-Probe Fluorescence Microscope with High Spatial Resolution |
This new pump-probe fluorescence microscope provides efficient, high-resolution, lifetime imaging of ultrafast fluorescence phenomena. It provides an economical alternative to existing confocal and fluorescence microscopes. This microscope provides superior resolution to standard fluorescence and two-photon microscopes and comparable resolution to confocal microscopes. In addition, it eliminates the problem of precision alignment that must be maintained with confocal microscopes. |
Microscopy, Urbana-Champaign | |
| Lymphatic Filariasis Vaccine |
Lymphatic
filariasis (LF), commonly known as elephantiasis, is a painful and profoundly
disfiguring disease. LF is a parasitic disease caused by microscopic,
thread-like worms that is transmitted through mosquitoes. Approximately 1.3
billion people, primarily long term residents of tropical or sub-tropical
areas, are at risk of contracting LF. |
Chicago, Infectious, Vaccines | |
| Macroporous Hydrogel Scaffolds for Cell Encapsulation in Regenerative Medicine | Chicago, NONE OF THESE, NONE OF THESE, Macromolecular Structure and Function, Research Tools and Reagants | ||
| Make New Connections with Masterless Soft-Lithography |
Masterless Soft-Lithography (m-SL) allows for the patterning of substrate surfaces through the adhesion of poly (dimethylsiloxane) (PDMS) to silicon oxide, silanes, and similar chemical functionalities. This enables the transfer of a polymer pattern into a surface through its physical contact with a lithographically modified PDMS stamp |
Processes, Urbana-Champaign | |
| Male Infertility Diagnostic and Companion Therapeutic |
Nearly one quarter of men worldwide are homozygous for a mutation in a gene that encodes a key sperm surface protein that is critical for normal sperm functioning in the female reproductive tract. Methods of detection of the genetic mutation, or the deficit of the protein on sperm, are predictive of reduced male fertility. Supplementation of sperm with the purified protein restores sperm function. |
Assays, Chicago, Gender-specific disorders, Reproductive | |
| MarketMaker |
MarketMakerTM is a collaboration of the University of Illinois Extension, the Initiative for the Development of Entrepreneurs in Agriculture, the Illinois Deoartment of Agriculture, and C-FAR. The idea for MarketMakerTM was an outgrowth of previous C-FAR projects exploring market opportunities for value-added meat products.
MarketMaker provides a one-stop shop for strategic marketing information for producers and food retailers alike. |
Database, Urbana-Champaign | |
| Matricellular Scaffold Modulators for Regeneration of Periodontal Tissues |
Periodontal disease is one of the major reasons for tooth loss in the United States and may be associated with systemic effects, including heart disease and rheumatoid arthritis. Although tooth retention has greatly improved over the past few decades, a significant percentage of older Americans do not have functional dentitions and only 42.4% of the U.S. |
Chicago, Dental, Digestive, Rheumatologic, Biomaterial, Cellular Engineering | |
| Matrix-Metalloprotease Activation of Chemotherapeutics from Hydrogel Matrices |
Each year approximately 13,000 people die from malignant brain tumors in the U.S. Glioblastoma multiforme (GBM) is a highly aggressive brain tumor whose prognosis with currently available treatments is bleak. The following invention attempts to address this problem by using a hydrogel-based delivery system that can control the release of drugs based on the activity of matrix metalloproteases (MMPs). |
ALL OF THESE, Chicago, NONE OF THESE, Oncologic, Therapeutic | |
| Mechanical Device for Jaw-thrust and Chin Lift |
UIC researchers have developed a mechanical device that will perform jaw‐thrust and chin-tilt (instead of chin-lift) in patients with suspected neck/cervical spinal injury, thus freeing the rescuer to attend to other aspects of stabilization of critically ill patients. |
Chicago, Pulmonary, Respiratory, Invasive device, Therapeutic hardware/ software/medical devices | |
| Medical Crochet Hat for Infants with Respiratory Distress Syndrome |
Respiratory
distress syndrome occurs in
0.5%
to 1.0% of all deliveries and in 10% of all premature deliveries. |
Chicago | |
| MedPen – Portable Laser Cautery Tool |
UIC
researchers have developed a next generation laser cautery tool and scalpel
using today’s fiber laser technology. This compact, turn-key, and alignment
free device will provide the field paramedic or warfighter with a unique,
portable, and battery-operated laser for coagulation or hemostatic control of
bleeding vessels, closing wounds while minimizing risk of infection, and
quickly cutting soft or hard bodily tissues.
|
Chicago | |
| Metal-Assisted Etching for Improved Porous Semiconductors |
The invention is a novel method for manufacturing porous semiconductors, including silicon (Si), gallium nitride (GaN) and silicon carbide (SiC). The method involves applying a thin, discontinuous metallic (preferably platinum) layer to a semiconductor wafer, prior to using common wet chemical etchants (e.g., hydrogen fluoride, hydrogen peroxide), to produce porous silicon (PSi) or other porous semiconductors (PGaN, PSiC). |
Processes, Urbana-Champaign | |
| Metaspectra: Software for Storage and Retrieval of Spectral Metadata |
Metapectra is an online database of spectral peaks and associated software that allows for easy searching by wave number, tissue, bond type and other characteristics, thereby enabling quick retrieval of information. All peaks in the database have biographical information - the scientific paper it is found in and the author of the paper - allowing for easy citation.
In spectroscopy, one common issue is determining the meaning of a peak on a spectrum of a tissue sample. |
Educational/Research Tools, Urbana-Champaign | |
| Method and Apparatus for Monitoring the Dynamic Function of Middle Ear Muscles |
Our ability to follow verbal instructions is dependent on
the proper functioning of the middle ear muscles. This becomes more difficult as the acoustical
features in our modern environment
become more complex and noisy. Currently, middle ear muscle function is
monitored through clinical tympanometry and acoustic reflex (AR) testing. |
Chicago | |
| Method for Depositing Multi-element Complex Structures by Chemical Vapor Deposition (CVD), Atomic Layer Depositions (ALD), or a Combined Alternating Mode using a Single Deposition System |
This invention is a novel method for depositing multi-element complex structures by chemical vapor deposition (CVD), atomic layer deposition (ALD), or a combined alternating mode using a single deposition system. The technology can be easily adapted to add more precursors or oxidizing reagents and can be used in continuous or cyclic modes to deposit simple or multi-metal films, or more complex structures such as multilayered stacks or nano-laminates.
Working prototype exists |
Chicago, Coatings | |
| Method for large-scale fabrication of atomic-scale structures on material surfaces using surface vacancies |
This technology is a method for making modifications to semiconductor wafers on an atomic scale, creating "nanowires" or "nanoclusters" on a commercially viable scale. These types of modifications will become more important as the line-widths of processors decrease beyond the physical limits of current production techniques. In this case, transistors and other components will have to be made at the atomic level to improve performance and speed. |
Processes, Urbana-Champaign | |
| Method for Non-invasive Diagnosis of Endometriosis |
Endometriosis is one of the most common gynecological disorders, affecting up to 10-15% of women of reproductive age, more than 5.5 million women in North America alone. The two most common symptoms of endometriosis are pain and infertility and about 30 percent to 40 percent of women with endometriosis are infertile, making it one of the top three causes for female infertility.
With an estimated symptomatic population of six million women and serious problems resulting in low fertility, there is a significant latent potential. |
Assays, Chicago, Diagnostic biological tests/assays, Gender-specific disorders, Reproductive | |
| Method of Inhibiting Tumor Cell Proliferation |
Liver cancer (HCC) is the fifth most common cancer in the world. A deadly disease, liver cancer will |
ALL OF THESE, Chicago, NONE OF THESE, Oncologic, Therapeutic | |
| Method to Suppress Stimulated Brillouin Scattering in Optical Fibers |
Developed by researchers at the University of Illinois at Urbana-Champaign, this new fiber optic technology suppresses stimulated Brillouin scattering (SBS) in fiber laser technologies, |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Methods for Producing Fertile Crosses Between Wild and Domestic Soybean Species |
Soybean
crop is susceptible to a variety of threats including soybean cyst nematode
(SCN), soybean rust, bean pod mottle virus (BPMV) and aphids. SCN is currently the largest pest of soybean
and can be controlled with crop rotation or nematicides, however, crop rotation
is not always successful and nematicides can be expensive and harmful to human
health. Generation of a soybean that is genetically resistant to SCN (and other
diseases) would avoid these complications. |
Crops and Germplasm, Urbana-Champaign | |
| Micellar-encapsulation of thiostrepton increases solubility and tumor accumulation |
The proteasome is a protein complex that targets
ubiquitin-tagged proteins for degradation in an ATP-dependent manner. Proteasomes
are prone to hyperactivity in cancer cells.
Recent studies show that proteasome inhibitors, such as thiostrepton,are
effective anticancer therapeutics via inhibition of FoxM1 expression and
transcriptional activity. FoxM1 is an oncogenic
transcription factor that is one of the most
overexpressed genes in cancer. |
Chicago | |
| Micelle Drug Delivery System that Reduces Risk of Toxicity and Improves Compound Targeting |
Bioavailability of therapeutic agents is an important limiting factor in successful therapeutic treatment. Formulations that can enhance the bioavailability and activity of the therapeutics are highly desirable. UIC researchers have developed novel drug delivery agents that have been found to significantly enhance the efficacy of potential therapeutic agents. |
Chicago, Drug delivery | |
| Microcantilever heater-thermometer with integrated temperature compensated strain sensor |
Thermal sensitivity in piezoresistive sensors used in silicon microcantilevers makes them susceptible to unwanted signals such as temperature drift. In addition, when used in chemical sensing, current microcantilevers have difficulty testing femtogram (10-15) scale samples due to the effect of temperature variations on the mechanical signal.
This invention is a microcantilever hotplate with both a resistive heater and temperature-compensated piezoresistive strain gauges that correct for the effect of temperature variations on the mechanical strain signal. |
MEMS Devices, Urbana-Champaign | |
| Microdischarge Photodetectors |
This invention allows for the production of a family of photodetectors that are sensitive in the ultraviolet, visible, and near-infrared regions of the spectrum. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Microfabricated Fluid Channels |
Designed to eliminate the time-consuming dipping required for inking the dip pen nanolithography (DPN) array used for nanoscale patterning, this invention provides a method for providing fluids "inks" to a large array of scanning probe microscope tips. |
Urbana-Champaign | |
| Microfabrication of Membranes for the Growth of Cells |
All cells respond to chemical and physical cues form their environment to program their gene regulat |
Cardiac, Chicago, Circulatory, Muscular, NONE OF THESE, Cell Biology, Biomaterial, Cellular Engineering, Gene and Cell Therapy, Research Tools and Reagants, Therapeutic, Therapeutic hardware/ software/medical devices | |
| Microfluidic Device Platform for Perfusion Chamber Systems |
In
stroke research, the hippocampal acute brain slice preparation is a model for
studying how neuronal tissue responds to a hypoxic insult. Additionally, in diabetes research,
pancreatic islets preparation and dynamic loading of oxygen and glucose is
critical to understand how hypoxia alters the glucose-insulin response of the
pancreas. However, standard techniques
using commercial perfusion chambers cannot accurately provide oxygen delivery
and control to model hypoxic conditions. |
Chicago, Diagnostic biological tests/assays, Digestive, Gastrointestinal, Micro/nano scale, Nervous, Neurologic | |
| Micronutrient Fortification and Delivery |
More than three million people worldwide are afflicted with disorders caused by micronutrient deficiencies that are often preventable. |
Food processing, Urbana-Champaign | |
| Microscale Liquid Conductivity Sensors |
Conductivity of a liquid solution provides valuable information about the solution, but commercially available conductivity probes are costly and have diameters greater than 1cm, limiting their potent |
Non-MEMS Devices, Urbana-Champaign | |
| Microvascular Networks and Composite Materials Using Sacrificial Fibers | Composites, Urbana-Champaign | ||
| Miniature 3-axis horizontal micro-milling machine |
This invention is a 3-axis machine for micro-milling and drilling. It is built through the compilation of new uses for existing technology, improvements of existing products, and novel solutions to the design challenges of a miniature machine tool. This machine solves several of the problems that have been associated with creating a miniature micro-machining platform and takes miniature machine tools from the laboratory stage of development to a product that can be easily commercialized. |
Civil, Mechanical and Industrial, Urbana-Champaign |
|
| MIRUNDS: A Novel Convention for Describing Purity of Spectrometrically Validated Botanical Reference Materials |
Natural product chemical compounds and reference materials are often complicated mixtures that are currently classified with a percentage of purity. However, these products are simply labeled with obscure percentages and no explanation as to the remaining constituents. The current labeling system provides no indication as to which impurities are present and if those impurities will negatively affect the outcome of procedures using these reference materials. |
Chicago | |
| Mitochondrial Anti-Oxidants for Prevention of Cardiovascular Disorders |
Angiotensin II activation and associated elevation in reactive oxygen species have been implicated in pathogenesis of many cardiovascular disorders including arrhythmia. Nevertheless commonly-used antioxidants have been shown to be ineffective in clinical trials. |
Chicago | |
| Mobile Application for Calculating Digoxin Dosage |
This application is designed to allow healthcare providers to calculate an appropriate, individualized dose for digoxin for their patients using simple, easily retrievable clinical and demographic characteristics. The application will do so for both a bolus, or loading dose, as well as a maintenance dose. Additionally, the digoxin dose may be individualized by indication (atrial fibrillation or flutter, heart failure, or both) and desired digoxin concentration. |
Applications, Cardiac, Chicago, Circulatory | |
| Model Based Environment For Validation of System Reliability, Availability, Security and Performance |
MobiusTM is a software tool for modeling the behavior of complex systems. Originally developed for studying the reliability, availability, and performance of computer and network systems, its use has expanded to include a broad range of discrete-event systems from biochemical reactions within genes to the effects of malicious attacks on secure computer systems.
The flexibility and power found in MobiusTM come from its support of multiple high-level modeling formalisms and solution techniques. |
Debug/Optimize/Secure, Urbana-Champaign | |
| Modeling of microfluidic systems for high throughput cell culture | Urbana-Champaign, Cell signaling, Research Tools and Reagants |
|
|
| Modulating Cardiac Sodium Channels to Treat Cardiac Related Sudden Death |
Cardiovascular disease continues to be a leading cause of death in the Western hemisphere. Cardiac arrhythmias affect more than 5 million people annually in the United States, resulting in more than 1.2 million hospitalizations and 400,000 deaths each year. Heart failure affects 4.7 million Americans, 1.5% of the total population. |
Cardiac, Chicago, Circulatory, Drug targets, Research Tools and Reagants |
|
| Modulation of Multidrug Resistance by New Tropane Alkaloid Aromatic Esters from Erythroxylum pervillei |
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ALL OF THESE, Chicago, Oncologic, Antibiotic, Therapeutic | |
| Modulation of Opioid Analgesics by CaMKII Inhibitors | ALL OF THESE, Analgesic, Chicago, Pain, Therapeutic | ||
| Molecular Biomedical Engineering |
These patent-pending optical contrast agents and molecular detection technologies were developed to enhance the ability of optical coherence tomography (OCT) to non-invasively map molecules in living specimens and diagnose disease where it starts. OCT utilizes low-coherence interferometry to measure the intensity of reflected or backscattered light to form images with micrometer resolution, is readily integrated with existing optical instrumentation and has application across a wide range of biological, medical, surgical, and non-biological specialties. |
ALL OF THESE, ALL OF THESE, Assistive device, Circulatory, CT, Diagnostic biological tests/assays, Hematologic, NONE OF THESE, NONE OF THESE, Urbana-Champaign, Imaging, Biomaterial, Gene expression, regulation and signal transduction, Invasive device, Marker, Diagnostic hardware/software/medical devices, Molecular Biology, Drug Design, Proteins, Enzymes, Genomics/proteomics, Sythesis and Analysis, Research Tools and Reagants | |
| Mouse model for mutant allele of the cell cycling inhibitor BARA in mice. | Chicago, NONE OF THESE, NONE OF THESE, Disease Model, Research Tools and Reagants |
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| Mouse Model for Studying Autoimmunity and Inflammation in Atherosclerosis |
Atherosclerosis
is an immunoinflammatory disease elicited by lipid accumulation in an arterial wall.
Increasing evidence suggests that the immune system is a major factor
modulating atherogenesis. Naturally
arising CD4+CD25+ regulatory T cells (Tregs) which actively maintain
immunological tolerance to self and nonself antigensare powerful atherogenicinhibitors.
Thus, new therapeutic approaches for
atherosclerosis may involve immune modulation using Tregs.
|
Chicago | |
| Multi-functional Multi-layered Nano- & MicroFluidic Device |
This technology describes a fabrication method for multi-channel, multi-layered microfluidic devices, with numerous functional characteristics capable of integration into a lab-on-a-chip platform. The chip allows broader analytical capabilities in point-of-use microfluidic technology than previously possible, and it does so with exceeding strength and stability. |
MEMS Devices, Urbana-Champaign | |
| Multicomponent coupling and glycopeptide synthesis with |
Development of efficient chemical ligation methods for the attachment of small molecules to peptides and proteins, for conjoining two proteins, and for the attachment of oligosaccharides to peptides and proteins is a current research frontier in chemical biology. Large glycopeptides or proteins are generally prepared from smaller fragments by convergent synthesis, and chemical ligation is a critical step in assembling large molecules from smaller building blocks. The present invention is related to the use of cyclic thioanhydrides as linchpins in multicomponent coupling reactions. |
Chicago, Drug Design, Research Tools and Reagants | |
| Multiple Wavelength DBR Laser |
The invention is a general design for a simultaneously emitting, dual wavelength diode laser for electronically simpler and more efficient remote sensing (e.g., water vapor on Mars, wind/weather analy |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Multiple-Input Buck Boost Power Converter |
This technology is a power converter circuit to convert multiple direct current (dc) inputs to one or more dc outputs. This dc-dc power converter allows its load to be powered by multiple, different sources of various voltage and current levels (such as solar panels, batteries, fuel cells, etc.). This converter has both buck and boost capability. |
Energy-Active, Urbana-Champaign |
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| Multiple-use Corn zein-based Biodegradable Resins, Sheets, and Films are an attractive alternative to plastic |
This technology is a process for preparing biodegradable resins comprised of corn zein and fatty acids and forming the resins into sheets, thin films, and similar products useful in a broad range of food packaging and agricultural applications. Corn zein-based Biodegradable Resins present an environmentally friendly alternative to plastic. |
Agricultural Engineering, Urbana-Champaign | |
| Multiplexed Sensor Arrays for Micro/Nanofluidic Networks |
The ability to increase the functionality and complexity of micro/nanofluidic devices is currently limited by the capacity to accurately detect the position of fluids within them.
While an increased number of electrical sensors can improve detection capabilities, the presence of too many external electrical connections makes integration into the micro/nanofluidic network difficult and complicated.
This invention is a method for connecting large arrays of electrical micro/nanofluidic sensors to external monitoring equipment, while using only a limited number of leads. |
MEMS Devices, Urbana-Champaign | |
| Mutations Of MDR1 P-Glycoprotein That Improve Its Ability To Confer Resistance To Chemotherapeutic |
The development of drug resistance in tumor cells is a major obstacle to clinical response in cancer |
Chicago, NONE OF THESE, NONE OF THESE, Oncologic, Disease Model, Research Tools and Reagants | |
| Nanofiber Coating of Surfaces for Intensification of Spray or Drop Impact Cooling |
Various methods are available for cooling high-heat flux electronic, optical and radiological devices. However, the miniaturization and breakthrough developments for these components are severely hindered by the need to cool them at heat fluxes on the order of 1 kW/cm2. There are many different approaches to cooling these devices: conduction and heat spreading, air cooling, piezo fans, synthetic jet cooling, nanolightning, liquid jet cooling (including liquid metal jets), heat pipes, cold plates, immersion cooling, micro-channel heat sinks and spray cooling. |
Chicago, Energy, Environmental Sciences and Materials | |
| Nanoscale, Electrified Liquid Jets for High Resolution Printing of Charge |
The ability
to print a polarized electrical charge onto a medium, or charge patterning, is
currently in the early stages of development.
A similar technology commonly used in office printers, Xerography,
thrives in large size regimes. There
exist only a few competitive technologies capable of printing at the nanometer
scale. Current technologies use
processes that provide only low resolutions and relatively poor control over
the printed charges. For example,
current atomic force microscopy probes can provide suitable charges, but are
only able f |
Non-MEMS Devices, Urbana-Champaign | |
| Nanotip Engineering Suite |
Developed by the University of Illinois at Urbana-Champaign, this suite of six technologies enhances multiple facets of nanolithography and scanning probe microscopy. The suite features multifunctional, active probe arrays that enable nanoscale and microscale printing with multiple fluids, nanotube micromachining techniques for high-resolution probe tips, fluid dispensing systems for multiple probes, and a simple
electrostatic actuation method for independently lifting individual probes in a high-density probe array. |
MEMS Devices, Urbana-Champaign | |
| Native Oxide (NatOx) Improves Aluminum-bearing III-V Semiconductor Devices |
NatOx is a well-known, proven, and patented technology that enables the formation of high-quality oxide layers on compound semiconductors, leading to improved performance and lower costs for optoelectronic and microelectronic devices.
Oxides provide crucial functions in semiconductors, including masking, passivation, isolation, and other more active functions. Although long available for silicon-based devices, a native (as opposed to deposited) oxide was not available for Group III-V semiconductors.
|
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Near-field Volume Scanning Optical Tomography |
The Near-field Volume Scanning Optical Tomography (NVSOT) improves upon the existing Near-field Scanning Optical Microscopy (NSOM) modalities by extending the data acquisition to obtain the tomographic information of the sample without multi-directional measurements or multi-angle illuminations.
Three-dimensional imaging is a much desired capability in the field of life sciences and nanotechnology; current techniques require multiple image acquisitions and complicated optical set-up.
|
Microscopy, Urbana-Champaign | |
| Near-infrared optical sensors based on single-walled carbon nanotubes |
Using single-walled carbon nanotubes (SWCNT), a technology for near-infrared (NIR) optical sensors has been developed. |
Diagnostic biological tests/assays, Urbana-Champaign, Biosensors |
|
| Neuropharmalogical Treatment of Sleep Apnea and Hyponea Syndrome |
Sleep apnea is a disorder characterized by periods in which a sleeping person is momentarily unable |
Chicago, Nervous, Neurologic, Pulmonary, Respiratory, Therapeutic | |
| New Design for the Endotracheal Tube |
Respiratory failure is not an uncommon phenomenon and may occur due to failure or malfunctioning of organs in the respiratory tract. In the case of this event, normal respiration is restored using a mechanical device called ventilator that delivers air to the patient with appropriate oxygen composition, at an appropriate rate. Air is delivered from the ventilator to the lungs through a specially designed tube, termed endotracheal tube. Endotracheal is inserted through the patient’s mouth or nose and passes through the throat and vocal cords. |
Chicago, Pulmonary, Respiratory, Invasive device, Therapeutic hardware/ software/medical devices | |
| New Drugs for Malarial and Bacterial Infections |
New anti-infectives are required now more than ever as resistance to existing drugs increases in preval |
ALL OF THESE, Infectious, Oncologic, Urbana-Champaign, Antibiotic, Therapeutic | |
| New Method for Producing Low Resistivity Paladium/Germanium (PdGe) Contacts on Group III-V Materials |
Group III-V semiconductor devices have many advantages over silicon-based semiconductors, including speed and the ability to produce optical emissions. For this reason, they are being widely used in optoelectric devices.
This technology offers a new method for producing low-resistance electrical contacts on Group III-V materials used in electrical and optical devices. The new method produces the lowest known resistivity PdGe contacts on gallium arsenide (GaAs). |
Processes, Urbana-Champaign | |
| New Nanotechnological Targeting System for Tumor Cells |
The
intricate requirements for successful drug carriers include a size limitation
of 50 – 200 nm in diameter in order to have prolonged and elevated levels in
the blood stream, while being able to selectively diffuse into the tumor
tissue. The limitations for active
targeting of tumor cells, which exploits specific ligand-receptor interactions
between the vector and the cancer cell, are even more stringent; the drug
carrier must be 1 – 10 nm in diameter to facilitate cellular uptake, and have
conformational flexibility to enhance targeting efficiency. UIC researchers hav |
ALL OF THESE, Chicago, Oncologic, Drug delivery | |
| New Purification Technology to Recover Industrial Process Fluids |
The University's proven, patent-pending filtration system offers an improved method for purifying industrial process fluids-such as parts washing cleaning solution and metalworking coolant-extending fluid lifetime and thus minimizing costs associated with chemical purchase and waste disposal.
This efficient and cost-effective technology consists of an integrated membrane filtration system that separates emulsified oils and contaminants from detergents, solvents, and metalworking coolant while using the machine's existing pumping system. |
Environmental Testing and Remediation, Urbana-Champaign | |
| New representation of countercurrent and partition chromatograms |
Counter-current chromatography (CCC) is a high resolution separation technique useful for fractionating complex mixtures, such as natural product extracts, under very mild conditions based on their relative solubility in two immiscible phases. Cross-platform comparison of CCC chromatograms is essential for the calibration, quality control, trouble shooting, and test performance of instruments, as well as rapid development of new CCC/CPC (Counter-partition chromatography) columns. |
Chicago, Chromatography, Research Tools and Reagants | |
| New Target for Breast Cancer Drug Therapy |
Breast cancer is the most common type of cancer diagnosed in women in the US and the second most common cause of death in women in the US. Treatment for breast cancer often involves a combination of surgery, chemotherapy, radiotherapy, and hormone therapy. Chemotherapy focuses on inhibiting estrogen binding to receptors, blocking estrogen production, targeting DNA replication, or preventing the division of cancer cells. Though clearly beneficial, the use of these drugs is severely limited due to serious adverse effects. |
Chicago, Oncologic, Reproductive, Drug delivery | |
| New Technologies for Cost-Efficient Manufacture and Improved Functionality of Microfluidic Devices for Medical and Biological Applications |
These three technologies improve the manufacturing and functionality of microfluidic devices. The technologies enable fast, easy, and inexpensive construction of microfluidic devices that can perform complex functions, have innovative designs, and operate autonomously. Devices fabricated using these technologies offer self-regulating functions, better "constriction regions" for positioning objects within the device, and the ability to create a large liquid-air interface by means of "virtual walls" in the device's channels. |
Life Sciences - Non-medicine, Urbana-Champaign |
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| New Technologies to Better Stabilize Colloid Particles |
These technologies provide greater control over the interactions of microscopic particles suspended within a liquid (i.e., colloids). |
Ceramics, Urbana-Champaign | |
| New Tomographic Reconstruction Algorithms for Faster CT Scans |
CT scanners are gathering more data than ever, far exceeding the ability of the hardware and software to process and analyze the data and consequently slowing down diagnosis. |
Urbana-Champaign | |
| New, easy-to-use web-based software tools give novice users the power of a webmaster |
NCSA has developed a software suite that allows novices to edit and manage content directly on a website and corporations to maximize the efficiency of both the users in their organization and of thei |
Business Software, Urbana-Champaign | |
| Nexturastat, a novel Urea-based HDAC6 inhibitor effective against specific cancers |
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped. |
Chicago, Circulatory, Oncologic, Angiogenesis | |
| Nonequilibrium Chemovoltaics Hydrogen Fuel Cell |
Nonequilibrium Chemovoltaics Hydrogen Fuel Cells has potentially of having a massive impact on the alternative energy systems market, and thus help-ing this nation to cope with the approaching energy |
Chicago | |
| Noradrenaline increases oligodendrocyte precursor cell maturation and modulates pathology in experimental autoimmune encephalomyelitis |
A demyelinating disease (DD) is any disease of
the nervous system in which the myelin sheath of neurons is damaged. DD of the
central nervous system such as Multiple Sclerosis(MS) , Optic Neuritis
typically have no cure. MS is an idiopathic disease of suspected autoimmune cause, in which the body's
immune response attacks a person's central nervous system, leading to
demyelination. It has a prevalence that ranges between 2 and 150 per
100,000.Treatments attempt to return function after an attack, prevent new
attacks, and prevent disability.
|
Chicago | |
| Novel Anti-Toxoplasma Gondii Agents Based on Triclosan and Cyclophanes |
Toxoplasmosis
is an infection caused by a parasite which multiplies in the intestine of a cat
and is shed in cat feces. It is passed
onto humans through contact with the feces, mainly from litter boxes and garden
soil. Healthy adults rarely suffer
harmful effects from Toxoplasma infection and are predominantly asymptomatic.
Primary infection in immunocompromised people causes a mild illness resembling
mononucleosis. However, the real danger
lies with infected pregnant women; up to 60% of infections are passed on to the
fetus, which has been shown in severe cases t |
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| Novel Anti-Toxoplasma Gondii Agents Based on Triclosan and Cyclophanes |
Toxoplasmosis
is an infection caused by a parasite which multiplies in the intestine of a cat
and is shed in cat feces. It is passed
onto humans through contact with the feces, mainly from litter boxes and garden
soil. Healthy adults rarely suffer
harmful effects from Toxoplasma infection and are predominantly asymptomatic.
Primary infection in immunocompromised people causes a mild illness resembling
mononucleosis. However, the real danger
lies with infected pregnant women; up to 60% of infections are passed on to the
fetus, which has been shown in severe cases t |
Chicago | |
| Novel Aspirin Analogs for the Targeted Therapy of ER+ Breast Cancer and Colon Cancer |
Breast cancer is the most common noncutaneous malignancy in women and second only to lung carcinoma in mortality. Approximately 75% of breast cancers express estrogen receptor (ER) and are further classified as luminal A and B. Five year survival rate of luminal B is ~50% compared to ~95% for luminal A, making luminal B a target for improved therapies.Inflammation is linked clinically and epidemiologically to cancer. In addition, activation of its downstream nuclear transcription factor NFκB appears to be of central importance in tumorigenesis. |
Chicago, Oncologic | |
| Novel Atherosclerosis Treatment |
Current therapies for atherosclerosis focus almost exclusively on
lowering blood cholesterol levels using pharmacological drugs, especially
statins, and none directly target the actual disease process in the artery
wall. Relative risk reduction exceeding
40% proves difficult to achieve with current therapies, and atherosclerosis
remains the primary cause of heart disease and stroke, accounting for up to 50%
of deaths in western countries.
Atherosclerosis is an imbalance between pathogenic T cells and
regulatory T cells in response to athero-antigens, and this imbalance
|
Cardiac, Chicago, Circulatory, Vaccines | |
| Novel Combination Therapy for Multiple Sclerosis and Alzheimer's Disease |
Multiple
sclerosis (MS) is a debilitating disease in which the immune system attacks the
myelin sheath of nerve axons, which impacts the neural communication signaling.
In Alzheimer's disease (AD), healthy
brain tissue degenerates, causing a steady decline in memory and mental
abilities. |
Chicago, Nervous, Neurologic, Therapeutic | |
| Novel Compounds for Multidrug-Resistant Anti-tuberculosis Agents |
Tuberculosis (TB) is a bacterial infection which primarily affects the lungs and central nervous system. One third of the world's population is infected with the bacteria Mycobacterium tuberculosis, the causative agent of TB. There are approximately 500,000 cases of drug-resistant TB reported annually, 6.6% of which are extensively drug resistant. To make matters worse, the number of annual TB cases is increasing due to population growth, along with the frequency of multidrug resistant TB (MDR-TB). |
Chicago, Infectious, Neurologic, Antibiotic, Therapeutic | |
| Novel Compounds for Treatment of Multi-Drug Resistant HIV/AIDS |
According to the Center for Disease Control, an estimated 850,000-950,000 people in the United States are infected with the Human Immunodeficiency Virus (HIV), which can cause Acquired Immune Deficiency Syndrome (AIDS). HIV has evolved from a death sentence for all patients to a chronic condition for most. While this is true, HIV can mutate in a way that allows it to become resistant to existing drugs, even when they are given in combination. As a result, people with multi-drug resistant HIV may find themselves without an effective treatment option. |
ALL OF THESE, ALL OF THESE, Chicago, Antiviral, Therapeutic | |
| Novel Compounds Identified with Anti-Tuberculosis Activity |
Tuberculosis (TB) is an infectious disease that claims millions of lives worldwide each year. According to the World Health Organization, every country surveyed has disease strains that are resistant to a single anti-TB drug. The emergence of single, multi-drug and extensively drug-resistant tuberculosis incidences highlights the urgent need for the discovery and implementation of novel anti-TB therapeutics. |
Chicago, Infectious, Respiratory, Therapeutic | |
| Novel Compounds Interact with Nuclear Receptors to Combat Disease |
Hepatitis B or C is the most
important cause of hepatocellular carcinoma (liver cancer), particularly in patients
with chronic active hepatitis. It has
been reported that cancer chemotherapeutic agents can reactivate type B
hepatitis in asymptomatic carriers and HIV-infected patients are at increased
risk of hepatocellular carcinoma caused by the hepatitis B virus. Chronic hepatitis B virus infections can be
treated with various antiviral agents or interferon alpha therapy that inhibits
viral replication. However, the reason
these treatments fail is due to the exis |
Chicago, Endocrine, Endocrine, Infectious, Oncologic, Antiviral | |
| Novel cube antenna based on three magnetic loops and three |
The new antenna is a proposed antenna to function as a theoretical collocated six element vector antenna, i.e. three collocated orthogonal magnetic loops and three collocated orthogonal dipoles. |
Chicago, MEMS Devices | |
| Novel Device for Tensile Testing of Sub-Micron Scale Freestanding Thin Films |
This technology is a new experimental method and device for the on-chip, uni-axial tensile testing of freestanding thin films, with virtually no restriction on film thickness (nanometers to micrometers). The method obviates the use of separate gripping mechanisms, ensures virtually perfect specimen alignment, and accurately calibrates loading of the specimen with required force resolution. |
MEMS Devices, Urbana-Champaign | |
| Novel Diagnostic and Therapeutic Targets for Krabbe Disease |
Scientists at the
University of Illinois at Chicago (UIC) have identified a novel therapeutic
target and an early diagnostic biomarker for Krabbe disease. One of these targets, serine/threonine
protein Phosphatase (PP1) will be used in the development of
therapeutics and the other for development of diagnostics.
|
Chicago | |
| Novel diagnostic technique for assessment of risk of stroke and other vascular diseases |
Stroke is a leading cause of death and long-term disability in the United States and Europe every year. Statistics provided by the American Heart Association indicate that about 140,000 individuals die each year in the United States, or one every four minutes. According to the World Health Organization, about 650,000 Europeans die each year due to stroke. In total every year approximately 785,00 people in the United States have a stroke, with over 600,000 of these being first or new strokes. While increased age is a risk factor for stroke incidence, near |
Chicago, Circulatory, Ophthalmalogical, Imaging | |
| Novel epoxide-based, calpain inhibitors as promising candidates for treatment of Alzheimer's Disease (AD) |
Calpain 1 is a calcium dependent cysteine protease, which is localized and abnormally activated in the synapses of brains in patients with Alzheimer's disease (AD). Calpain inhibition is an emerging target for AD therapy making compounds showing high selectivity for calpain inhibition highly attractive in AD treatment. This technology describes synthesis and characterization of several potential epoxide-based molecules as calpain 1 inhibitors. |
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| Novel Forceps Design to Decrease the Risk of Spinal Cord Injury During Electrode Insertion |
A laminectomy is a surgery that removes a
portion of the vertebral bone to relieve back pain. It is performed when
more conservative medical treatments have failed. Frequently performed on
patients who suffer severe pain due to herniated disks, the procedure requires
that surgeons insert a paddle type electrode onto the spinal cord for stimulation. Currently, surgeons use straight or
bayonet-type forceps and must firmly grip the edges of the electrode to ensure
its stability. However, this tends to
bend the electrode in a “U” shape resulting in increased press |
Chicago, Nervous, Neurologic, Invasive device, Therapeutic hardware/ software/medical devices | |
| Novel formulation of Decitabine with increased efficacy for treating cancer and blood disorders |
Decitabine is used for cancer treatment and other hematological disorders. The UIC inventors have developed a novel formulation of Decitabine. This formulation has improved oral absorption, decreased inter-individual variability, and improved efficacy against cancer cell resistance. |
Chicago, Oncologic, Gene and Cell Therapy | |
| Novel Human Hematopoietic Growth Regulatory Gene and Uses |
Hematopoietic stem cells (HSCs) have the unique ability to undergo self-renewal and to differentiate into cells belonging to multiple hematopoietic lineages. The ability of stem cells to self renew allows them to maintain hematopoiesis throughout the life span of an organism. The knowledge of the behavior of HSCs is limited due to their rarity, difficulty of efficient isolation, and sensitivity to manipulation. |
Chicago, NONE OF THESE, NONE OF THESE, Stem cells, Therapeutic | |
| Novel in vitro growth of human prostate tissue from stem cells for studying human prostate development. | Chicago, Gender-specific disorders, Reproductive, Research tools, Cell line, Research Tools and Reagants | ||
| Novel Inhibitors of Animal Cell Motility and Growth |
Cell motility is a central feature of a range of normal and pathological processes, including embryo |
ALL OF THESE, Chicago, Oncologic, Research Tools and Reagants, Therapeutic | |
| Novel Isoxazole-Based HDAC6 Selective Inhibitors for the Treatment of Charcott-Marie-Tooth (CMT), a new epigenetic approach to therapy |
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. |
Chicago, Muscular, Nervous, Neurologic, Oncologic, Therapeutic |
|
| Novel Materials for Use as Blood Substitutes |
Blood transfusions provide important medical benefits primarily centered on the replacement of lost blood in trauma and surgical patients.
|
Perinatal, Reproductive, Respiratory, Urbana-Champaign, Cell Biology, Cell line, Research Tools and Reagants | |
| Novel Method of Creating Human Brain Cells from Human Mesenchymal Stem Cells |
Stem cells show much promise in their potential to cure various neurodegenerative diseases such as A |
Chicago, Nervous, Neurologic, Ocular, Ophthalmalogical, Cell signaling, Research Tools and Reagants, Stem cells | |
| Novel Method Of Transplanting Neurospheres Into Brain Ventricle |
The capability for in vitro expansion of human
neural stem cells (HNSCs) provides a well characterized and unlimited source
alternative to using primary fetal tissue for neuronal replacement therapies.
The HNSCs injected into the lateral ventricle of 24-month-old rats after in
vitro expansion, displayed extensive and positional incorporation into the aged
host brain with improvement of cognitive score assessed by the Morris water
maze after 4 weeks of the transplantation. |
Chicago | |
| Novel Microcombustor for Highly Efficient Generation of Electric Power from Fuel |
This technology is a microcombustor a compact, submillimeter device that burns hydrocarbon fuels homogeneously as a source of power. |
Air, Urbana-Champaign | |
| Novel Microfluidic Technology for Encapsulating Cells for Therapeutic Implantation Without Rejection |
Scientists at the University of Illinois at Chicago propose a novel method for microfluidic cell encapsulation. The invention allows for the encapsulation of pancreatic cells, which can then be implanted into patients to take on the insulin-producing function in type-1 diabetes patients without the risk of rejection by the immune system. |
Chicago | |
| Novel Molecular Mechanism of c-Src Regulation |
Src family kinases (SFKs) are associated with normal cellular homeostasis and their activity is elevated in some pathological conditions such as cancer and acute inflammation. In many human cancers, SFKs have been found to be overactive and transforming. In addition, elevated SFK activity is associated with tumor growth, survival, migration, and metastasis. Recent clinical trials have used SFK inhibitors in the treatment of breast canser and non-small cell lung cancer. |
Chicago, Oncologic, Therapeutic | |
| Novel Organic Materials with Exceptional Nonlinear Optical Properties |
These innovative organic materials offer many of the optical performance characteristics of inorganic materials. However, these organic materials have few of the drawbacks inherent in the processing of comparable inorganic materials. Unlike inorganic materials capable of similar performance, this technology is exceptionally easy and considerably less expensive to process. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Novel Orthopedic and Orthodontic Implant |
Titanium implants are conventionally used in
orthopedic medicine and dentistry to replace defective skeletal structures such
as bone and teeth. The use of titanium to replace the lost skeletal function
produces predictable results; however, the area of immediate and long-term osseointegration
still needs improvement. Current methods are focused mainly on repair over
regeneration. Therefore, even implants that initially osseointegrate properly
can fail years later because of osteolysis at the bone-implant interface. |
Chicago | |
| Novel Out-of-Plane, Arrayable Hot-wire Anemometer and Fabrication Process |
This invention is a novel, out-of-plane, hot-wire anemometer and a microfabrication method for producing it. Its composition and innovative production process enable the sensing element to be raised out of the plane of the substrate and thus arrays of sensors can be easily formed. Out-of-plane sensors provide greater sensitivity by virtue of higher thermal isolation and out-of-plane sensor arrays enable true three-dimensional representations of the flow. |
MEMS Devices, Urbana-Champaign | |
| Novel Peptide Inhibitors of Protein Synthesis, Methods of Identifying and Their Use | ALL OF THESE, ALL OF THESE, Chicago, Drug Design, Proteins, Genomics/proteomics, Research Tools and Reagants | ||
| Novel phospholipid micellar and liposomal formulations of antibiotics and antitoxins |
UIC researchers have developed a novel phospholipid micellar and liposomal formulation of antibiotics and antitoxins. The use of Polymyxin B (PxB) Sterically Stabilized Micelles (SSM) was tested. The formulation can be applied in pharmaceutical products incorporating antibiotics, including those to which resistance develops, and drug delivery. Delivering the antibiotics in the phospholipid construct will provide solubility, stability, and avoid resistance. |
Chicago, Infectious, Drug delivery | |
| Novel Radioprotective Drug for the treatment of Radiation Pneumonitis and Radiation Induced Lung Injury |
The
inherent sensitivity of normal lung tissue to radiation presents a unique
challenge in thoracic radiation therapy.
Thoracic radiation is used to treat of malignant cancer in the thoracic or
chest cavity. |
Chicago, NONE OF THESE, Oncologic, Pulmonary, Respiratory | |
| Novel screening method for oral, lung, and GI cancer |
Dr.
Schwartz, the UIC inventor, hypothesizes that an oral bacterial flora profile
reflects not only proximal oral infections such as periodontal disease but
correlates to the presence of distant cancers such as lung cancer. Given the prevalence of lung cancer, the
development of lung cancer diagnostic tools based on the inventor’s hypothesis
may have significant commercialization potential. Lung cancer causes 1 in 3 cancer deaths. Every year in the United States., 99,000 men
and 78,000 women develop lung cancer.
|
Chicago | |
| Novel self-assembled toroidal-spiral microparticles with applications including drug delivery and sustained release of proteins and oligonucleotides |
Current methods for producing microparticles and therapeutic aerosols (emulsions, double emulsions, spray drying, supercritical anti-solvent process) involve two- or three-phase systems and temperature changes. These processes have severe limitations which include: |
Chicago, Drug delivery | |
| Novel series of photoreactive benzamide probes for histone deacetylases |
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histones, increasing their positive charge and encouraging high-affinity binding between histones and the DNA backbone. The increased DNA binding condenses DNA structure, preventing transcription. |
Hematologic, Oncologic, Research Tools and Reagants, Therapeutic | |
| Novel siRNA and gene therapy delivery technology with reduced risks of an immunogenic response. |
UIC scientists have developed a novel Sterically Stabilized Lipid Nanoparticle (SSLN), which have superior properties that allow them to deliver gene material to mammalian cells. These particles incorporate naturally existing materials that coat proprietary synthetic molecules to exhibit low immunogenicity. The Nanoparticles can be pre-manufactured in bulk then coupled with receptor-targeting moeities for tissue specific delivery. The technology has been validated in-vitro on mammalian cells with high transfection rates. |
Chicago | |
| Novel Synergistic Combination: Proteasome inhibitors and Thiazole Antibiotics as Potent Anticancer Agents |
The proteasome is a protein
complex that targets ubiquitin-tagged proteins for degradation in an
ATP-dependent manner. Recent advances in the understanding of the mechanisms of
proteasome activity led to the development of proteasome inhibitors as
effective drugs against human cancer. However the precise mechanisms of the
anticancer activity of proteasome inhibitors were not well understood. |
Chicago, NONE OF THESE, NONE OF THESE, Genomics/proteomics | |
| Novel Synergistic Combination: Proteasome inhibitors and Thiazole Antibiotics as Potent Anticancer Agents |
The proteasome is a protein complex
that targets ubiquitin-tagged proteins for degradation in an ATP-dependent
manner. Recent advances in the understanding of the mechanisms of proteasome
activity led to the development of proteasome inhibitors as effective drugs
against human cancer. However the precise mechanisms of the anticancer activity
of proteasome inhibitors were not well understood. |
Chicago | |
| Novel target for estrogen sensitive breast cancer cell inhibition, the HSC17B7 gene product |
Breast
cancer is projected to be diagnosed in one out of every eight females born
today in the United States. As highly-visible public awareness campaigns, like
the pink ribbon and various Susan G. Komen sponsored activities, have educated
the public about breast cancer, the market has become increasingly anxious for
therapeutics solutions to the disease. Therapeutics for fighting and preventing
breast cancer are not currently available on the market and researchers are
looking for new pathways to explore. |
Oncologic, Reproductive, Drug targets, Research Tools and Reagants |
|
| Novel target for the treatment of malaria |
An estimated 300 million to 500 million cases of malaria occur worldwide annually. Approximately 2.7 million people die as a result of malaria each year. |
Chicago, Infectious, Nervous, Neurologic, Proteins, Genomics/proteomics | |
| Novel therapeutic agents for the treatment of hepatitis C virus infection by inhibiting NPC1L1 |
Hepatitis C is a blood‐borne infectious disease that is
caused by the Hepatitis C virus (HCV), affecting the liver. The infection is often
asymptomatic, but once established, chronic infection can cause inflammation of
the liver (chronic hepatitis). This condition can progress to scarring of the
liver (fibrosis), and advanced scarring (cirrhosis). In some cases, those with cirrhosis
will go on to develop liver failure or other complications of cirrhosis,
including liver cancer. An estimated 150‐200 million people worldwide are
infected with hepatitis C. |
Chicago, Digestive, Infectious, Antiviral, Therapeutic | |
| Novel Urea-Based HDAC6 Inhibitors for the Treatment of Various Neurodegenerative and Immune Diseases, a new epigenetic approach to therapy |
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. |
Chicago | |
| Novel vector antenna for direction of arrival (DOA) estimation, source localization and channel capacity enhancements |
This vector is a six element vector antenna (SEVA). |
Chicago, MEMS Devices | |
| Nuclear Material Sensor |
UIC researchers have developed a nuclear material sensor that detects gamma radiation at room temperature conditions. This sensor is constructed out of nanoscale materials which allows for reduction of detector size, weight, and complexity. Compared to similar products on the market, this technology is inexpensive and thus can be used in more applications. The unique design is able to function without cryogenic cooling. |
Chicago, Sensors | |
| Ohmic & Gate Contacts for High Electron Mobility Transistors (HEMTs) |
Ohmic contact degradation and gate-sinking are two major degradation mechanisms that cause semiconductor devices, such as high electron mobility transistors, or HEMTs, to fail. In general, the rapid diffusion of contact
metals into the indium phosphide substrates has restricted processing temperatures to 300ºC and reliable operating temperatures have been limited to 200ºC to 250ºC.
This set of technologies embodies two similar methods for improving reliability and performance of contacts in indium phosphide-based semiconductors. |
Processes, Urbana-Champaign | |
| One-Part Liquid Composite Molding Technique |
This technique for liquid composite molding uses a solid catalyst recrystallized onto preplaced fiber reinforcements to produce high-strength polymer matrix composites. |
Urbana-Champaign | |
| One-step Drug Nanoparticle Preparation |
Nanoprecipitation has emerged as an attractive strategy for preparing polymer nanoparticles used in drug delivery. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Drug Design, Drug delivery, Sythesis and Analysis, Research Tools and Reagants | |
| Optically-Activated Single-Bias Fast-Switching Integrated Thyristor for Power-Electronics Applications |
A common characteristic of thyristor architectures is the requirement of more than one bias voltage to control the power flow. A voltage bias is applied across the anode and cathode terminals for power flow. The other voltage bias is applied at the thyristor gate and at other auxiliary switches. By requiring more than one bias voltage for operation, the system complexity is greatly increased, more power is consumed, and reliability is reduced. |
Chicago | |
| Organic Inks for 3-D Writing |
A novel organic ink comprised of a mixture of anionic and cationic polyelectrolyte species in water has been developed for the robotic deposition of 2-D and 3-D patterned structures with micron-scale features. This invention offers a new approach for fabricating complex structures on micron length scales with potential applications as templates for photonic band gap materials, as well as scaffolds for tissue engineering, drug delivery, and nanoparticle assembly. |
Macro scale, Urbana-Champaign | |
| Overexpression of Splicing Factor is Observed in Human Ovarian Cancer Cells |
Ovarian cancer is the
most lethal gynecological malignancy and is expected to cause 14,600 deaths in
the United States in 2009. Despite
considerable advances in the treatment of this disease, the mortality of
ovarian cancer has not decreased significantly over the past decades, and the
majority of patients , especially those at advanced stages, still succumb to
it. |
Chicago | |
| Pan-specific, selective antibody for Amyloid Beta (Aß) protein |
Aß is found in high levels in pathological conditions such as dementia, vascular diseases, and traumatic brain injury. Currently, there is no antibody that is specific for Aß that does not bind to its precursor protein APP. The most widely used antibody today is 6E10. This antibody is priced at $905 for a half milliliter. The UIC inventors have developed an antibody that only binds to Aß and is pan specific in which it detects all forms of Aß (unaggregated, oligomeric and fibrillar forms). |
Antibodies, Chicago, Nervous, Neurologic, Immunoassay | |
| PARADISE: overcoming the current limitations of cardiac MRI |
This invention is an improved process for three-dimensional cardiac magnetic resonance imaging (MRI), designed to overcome the limitations of current MRI systems in imaging dynamic phenomena such as the beating heart, flow of contrast agents in blood vessels, brain excitation, or joint movement.
This invention produces motion movies of the beating heart, and other dynamic phenomena, with significantly higher spatial and temporal resolution than currently feasible. |
Cardiac, Circulatory, Muscular, Nervous, Respiratory, Urbana-Champaign, Imaging, MR, Diagnostic hardware/software/medical devices | |
| Parallel-Kinematics Flexure Stage (PKFS) |
This parallel-kinematics flexure stage (PKFS) generates a motion range larger than, or at least comparable to, current commercial designs while simultaneously eliminating the undesired secondary motion associated with them. As opposed to traditional positioning systems, parallel kinematics systems, because of their truss-like structures, are structurally stiffer and lighter and allow for high-bandwidth operations. In addition, errors associated with fabrication tend to cancel rather than compound each other. |
MEMS Devices, Urbana-Champaign | |
| Passive Control Scheme for Microfluidic Devices | MEMS Devices, Urbana-Champaign | ||
| Peptide Based Inhibitor of Calcium Current |
This technology is a short fragment of a naturally occurring peptide that can be used to regulate the density of calcium current in mammalian cells.
Modulation of calcium current across cell membrane |
Autoimmune, Circulatory, Hematologic, Infectious, Nervous, Reproductive, Urbana-Champaign, Gene expression, regulation and signal transduction, Gene and Cell Therapy, Genomics/proteomics, Therapeutic | |
| Peptide Inhibitor of Gα13 – Integrin Interaction Is Key In Thrombosis, Hemostasis, Cell Migration, Cancer Development, and Inflammatory Response |
Integrins are transmembrane proteins that mediate attachment between a cell and the environment surrounding it. Integrins convey information to a cell about the molecules in its environment so that the cell is able to respond. Conversely, integrins are also able to transduce information from the cell to the environment surrounding it. Thus, integrins are vital to cell growth, cell division, cell survival, cellular differentiation, and cell death. As such, inhibition of integrins has applications for treatment of thrombosis, inflammation, recanalization of blood vessels, and cancer. |
Chicago | |
| PerioSim™: a 2D and 3D Virtual Reality Dental Training CD for Teaching, Training and Testing Trainees Periodontal Probing Procedures |
Dental training involving patients is not practical for the novice student. The advent of virtual reality based techniques opens up new avenues in medical education. Virtual reality (VR) based training methods are highly cost effective, can be carried out a number of times and have the additional benefits of being able to record and evaluate performance with real-time feedback. With over 8000 students needing training annually in the US alone there is a need for an educational aid that addresses these goals. |
Chicago, Dental, Graphics/Visualization/Image, Therapeutic hardware/ software/medical devices | |
| Personalized Search |
This technology is a personalized search toolbar that adapts to user interest based on search context and history, returning results that have a high probability of reflecting the user's original search intent without requiring any explicit user feedback.
Based on research from the User-Centered Adaptive Information Retrieval (UCAIR) project in the Department of Computer Science, this technology complements search engines by providing more relevant results to the user. |
Search, Urbana-Champaign | |
| Pharmacological Treatment of Sleep-Related Breathing Disorders with Ondansetron and Fluoxetine |
Incremental serotonin withdrawal during
the wake to sleep transition has been postulated as a key mechanism that
renders the pharyngeal airway collapsible.
While serotonin promotion with reuptake inhibitors have demonstrated
modest beneficial effects during NREM sleep on obstructive sleep apnea (OSA),
animal studies suggest a potential therapeutic role for selective serotonin
receptor antagonists (5-HT3) in REM sleep. |
Chicago | |
| Phosphine-free rearrangement of allylic disulfides |
Development of efficient chemical ligation methods using very mild conditions for the attachment of small molecules to peptides and proteins, for joining two proteins, and for the attachment of oligosaccharides to peptides and proteins is an area of current research interest. For such methods to be useful and applicable to biological and biochemical systems, very high chemoselectivity, stability, compatibility with protic solvents and aqueous media are essential. |
Chicago | |
| Plant Derived Bio-Fungicide against Soybean Rust Disease |
Domestic soybean cultivars used in the U.S. are highlysusceptible to soybean rust disease caused by Phakopsora pachyrhizi. The rapid spread of the disease and its abilityto cause significant yield losses (ranging from 13 to 80% of total yield) canresult in major economic losses for soybean producers. Synthetic fungicides areheavily used (~74 million acres in US in 2007) to prevent rust disease buttheir effect on human health and the ecosystem is unknown. |
Crops and Germplasm, Urbana-Champaign | |
| Polyclonal Antibodies against Elements of the Human Parasites Brugia malayi and S. mansoni |
B. malayi, the causative agent for elephantiasis, is a mosquito-borne parasitic filamentary nematode that is endemic in many tropical regions. The larval form of B. malayi migrates to the lymphatic system of human hosts where it matures. The edema caused by the maturation of the parasite results in the swelling and tissue growths associated with elephantiasis. S. mansoni is one of three species of helminth parasite responsible for schistosomiasis, a debilitating liver disease that is endemic to many tropical regions. The function of Sm-GBF in S. mansoni is not presently known. |
ALL OF THESE, Chicago, NONE OF THESE, Oncologic, Therapeutic | |
| Polyclonal Antibodies for HSD17B7 [17β-hydroxysteroid dehydrogenase type 7 enzyme, formerly prolactin receptor-associated protein] |
Polyclonal antibodies for HSD17B7 [17β-hydroxysteroid dehydrogenase type 7 enzyme, formerly prolactin receptor-associated protein]. |
Antibodies, Chicago | |
| Polyclonal antibody 20alpha HSD [20 alpha-hydroxysteroid dehydrogenase, AKR1C1] |
Polyclonal antibody 20alpha HSD [20 alpha-hydroxysteroid dehydrogenase, AKR1C1]. |
Antibodies, Chicago | |
| Polymeric Self-healing Composites for Longer Lasting Products |
This proven, patent-pending material that enables a wide variety of composite products to "self-heal" is available for licensing by or joint development with commercial companies, universities, or government laboratories.
Structural polymers are susceptible to cracks that form deep within the structure where detection is difficult, and repair is often impossible. |
Macro scale, Urbana-Champaign | |
| Porphyric Insecticides: A Longer Lasting Solution to Insect Control |
This unique and highly effective insecticide chemically induces insects to accumulate high levels of tetrapyrroles, which causes insect death when exposed to daylight, and even when used in darkness.
This reaction creates an insecticide to which insects will have a much more difficult time building resistance. As a result, it will lengthen the useful life and cost-effectiveness of the insecticide. |
Crops and Germplasm, Urbana-Champaign | |
| Portable-Powered-Ankle-Foot-Orthosis |
This
technology is a novel, untethered, powered, ankle-foot-orthosis (AFO) design
that controls and assists ankle motion using plantarflexor and dorsiflexor
torque at the ankle joint. This device is called a Portable-Powered-Ankle-Foot-Orthosis
(PPAFO), and utilizes fluid-powered actuators to provide active ankle torque
assistance during gait. The system is self-contained and uses a portable
pneumatic and/or hydraulic power source and embedded electronics to power and
control the actuation of the foot. |
Assistive device, Muscular, Neurologic, Urbana-Champaign, Therapeutic hardware/ software/medical devices | |
| Power Allocation in Multitone Systems |
This technology is an algorithm designed to enhance power allocation in multichannel, orthogonal frequency division multiplexed (OFDM) telecommunications systems that use discrete multitone (DMT) protocol, among others. DMT includes all asymmetrical digital subscriber line (ADSL) systems and residential DSL systems. The algorithm serves to improve the achievable data rate or the signal-to-noise ratio (SNR), reducing errors in the transmission, and can be used for any OFDM system where the SNR varies across channels. |
Power devices, Urbana-Champaign | |
| Powerful Biphosophonates for Treatment of Cancer, Bone Loss, and Infectious Disease |
Although there are already a few existing compounds for use in the treatment of bone diseases, these new compounds may have efficacy exceeding that of current commercial species. |
ALL OF THESE, Oncologic, Urbana-Champaign, Immunotherapy, Therapeutic | |
| Pre-natal Diagnostic Testing and Evaluation Using Fetal Specific Antibodies |
Prenatal testing is used to detect birth defects, chromosome abnormalities, genetic diseases, or other conditions or diseases in a fetus or embryo. It can also be used to determine the sex of the fetus before birth. Such screening is useful to (1) enable timely medical or surgical treatment of a condition before or after birth, (2) give the parents the chance to abort a fetus with the diagnosed condition, and (3) give the parents the chance to psychologically, socially, financially, and medically prepare for a baby with a health problem or disability, or for the likelihood of a stillbirth. |
Assays, Chicago | |
| Predictive, Selective Oxidation of C-H Bonds in Complex Systems |
Professor
M. Cristina White has developed iron-based small molecule catalysts which, in
conjunction with hydrogen peroxide, can selectively oxidize aliphatic C-H bonds
in complex natural products. |
Urbana-Champaign, Sythesis and Analysis, Research Tools and Reagants |
|
| Preventing Inflammation-Induced Pulmonary Vascular Leakage |
Sepsis poses a significant health risk in the United States, with an estimated 750,000 severe cases annually. Studies estimate the overall hospital mortality rate for sepsis to be 14-29%, while another study found confirmed severe sepsis in 6.3% of intensive care unit patients, with an associated mortality of 56%. With an average cost of over $22,000 per case, the total annual costs due to severe sepsis were estimated to be $16.7 billion. Sepsis does not have a cure and currently only one drug has FDA approval for the treatment of severe sepsis. |
Chicago, Pulmonary, Respiratory, Anti-inflammatory, Therapeutic | |
| Printed Assemblies of Ultrathin, Micro-scale Inorganic Light Emitting Diodes for Deformable and Semitransparent Displays |
Display devices represent ubiquitous, central components of nearly all consumer electronics technologies. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Process for Improving Metal-Polymer Adhesion |
This novel method for depositing metal films on a polymer surface significantly increases the adhesion strength of metal-polymer interfaces by providing mechanical interlocking on a microscopic scale. |
Micro/nano scale, Urbana-Champaign | |
| Process for Producing Polymers with Improved Melt Flow Characteristics |
This technology simplifies manufacturing processes for plastics while also improving melt flow characteristics of polymers. |
Urbana-Champaign | |
| Production of Retinal Cells from Human Neural Stem Cells |
Millions of individuals suffer a lower quality of life as a result of blindness caused by retinal de |
Chicago, Ocular, Ophthalmalogical, Cell Biology, Research Tools and Reagants, Stem cells |
|
| Prolactin Receptor-Long expressing transgenic mice |
Transgenic mice which express only PRLR-L, ubiquitously (Tg-RL)
Transgenic mice which express only PRLR-L, in a CL-specific manner (CL-RL) |
Biomaterial | |
| PROMIS: An Extensible, Auto-parallelizing and Optimizing Compiler for C, C++, FORTRAN and JAVA |
PROMIS is a supercompiler that integrates a source code parallelizer and instruction-level parallelizer and optimizer, accommodating various languages (C/C++, Fortran etc) and different instruction-set architectures without changing the core compiler architecture. |
Systems, Urbana-Champaign |
|
| Quantification of AKT Protein Expression in Breast Cancer Patients |
A
cancer diagnosis is conventionally confirmed through histological examination
of cell or tissue samples removed from a patient. Clinical pathologists need to
be able to accurately determine whether such samples are benign or malignant
and to classify the aggressiveness of tumor samples deemed to be malignant,
because these determinations often form the basis for selecting a suitable
course of patient treatment. |
Chicago, Diagnostic biological tests/assays, Lymphatic, Oncologic | |
| Quantum Dot Encoding of Aptamer-Linked Nanostructures for One Pot Simultltaneous Detection of Multltiple Analytes |
Nanoparticle-based colormetric biosensors allow onsite, real-time qualitative or semi-quantitative detection without complicated analytical instruments. |
Urbana-Champaign | |
| Rapid MRI with High Motion Tolerance |
The
magnetic resonance imaging (MRI) market was worth $858.2
million in 2008. MRI is critical for
medical diagnosis of in a number of disorders. MRI uses magnetism, radio waves, and computer
to produce images of body structures. A
magnetic field aligns the protons of hydrogen atoms, which are then exposed to
a beam of radio waves. As radio waves
spin various protons in the body, the protons emit a signal that is detected by
the receiver of the MRI scanner.
Received information is processed by a computer to produce an image. Dr. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Diagnostic hardware/software/medical devices | |
| Rapid, less expensive and accurate analysis of mercury species in water |
This new technology provides a procedure, chemistry, and apparatus for rapid on-line concentration and HPLC-based separation of inorganic and monomethyl mercury in natural water, environment and tissue samples. This technology offers substantial improvement in time, cost, and labor required to complete the analysis. |
Urbana-Champaign, Water | |
| Rat decidual (GG-AD) and Rat luteal (GG-CL) cell lines |
Rat decidual (GG-AD) and Rat luteal (GG-CL) cell lines |
Chicago, Cell line | |
| Real-Time Imaging of Live, Thick Tissues Using a Near-Infrared Optical Imaging System (NOIS) |
The system provides a noninvasive, damage-free imaging technique for live subjects at a lower cost than traditional methods. |
Urbana-Champaign | |
| Real-Time, Remote, Interactive Internet Examination of Swallowing Function |
This software makes possible real-time, remote, dynamic transmission of fluoroscopic medical imaging sessions. Using standard MPEG video compression, a patient's medical images are transmitted in real time using a broadband Internet connection in a best-effort format. The transmitting computer, equipped with a video-encoding card and custom developed software is located in a remote hospital x-ray suite and is connected to a fluoroscope. |
Dental, Digestive, Gastrointestinal, Urbana-Champaign, Imaging, Diagnostic hardware/software/medical devices |
|
| Reliable NanoFET Biosensor Process with High-K Al2O3 Gate Dielectric |
This
technology is a unique method capable of being used to create very reliable
NanoFET biosensors – the processing method increases reliability dramatically
over currently used methods.
Currently, the industry does not possess a feasible method
to create NanoFETs for fluidic applications as such environments are quite
harsh on the FETs and they tend to fail rapidly. Processing has been done, up until now, predominantly
through a bottoms-up, self assembly, process that lends itself toward failure
in aqueous or biological fluidic settings. |
Sensors | |
| Repeated Electromagnetic Fields Shock (REMFS) delays and reverses cellular senescence and mortality by acting on an unprecedented cellular mechanism. |
University inventors have suggested a
novel method to delay or reverse the aging process of cells and delay
age-related diseases by using repeated electromagnetic fields shock (REMFS). The scientists have also identified the
cellular mechanism by which this technique works.
|
Chicago, NONE OF THESE, NONE OF THESE, Research Tools and Reagants | |
| RMPA Compact Pattern-Reconfigurable Microstrip Parasitic Arrays |
This invention is a class of low-power smart antennas, operating at millimeter and microwave frequencies, which are controlled by electronically manipulating the direction of an antenna's signal using |
Urbana-Champaign | |
| RNA from brush oral cytology to measure squamous cell carcinoma gene expression | Chicago, Dental, Diagnostic biological tests/assays, NONE OF THESE, Oncologic, Expression and purification, Gene expression, regulation and signal transduction, Genomics/proteomics | ||
| Robust Determination of Anisotropic Polarizability of Nanoparticles Using Coherent Confocal Microscopy |
It is currently difficult to determine the shapes of nanoparticles. Current methods rely on fluorescence or Raman-spectroscopy, yet these methods are not always reliable, especially in high-noise environments, and they do not offer a three-dimensional characterization of the nanoparticle.
This invention is a technique to identify shapes inferred from scattering properties of nanoparticles with no prior knowledge of the shapes.
|
Microscopy, Urbana-Champaign | |
| Robust Ellipsoid Algorithm for Faster Responding Control Systems |
Model predictive control (MPC) is the method of choice for controlling multivariable processes. However, as processes become more and more complex or as measurements and responses are needed on a rapid-fire basis, MPC's ability to handle constraints well and avoid instability is diminished.
The University's robust ellipsoid algorithm was developed to improve MPC performance in processes with a high rate of measurement or extremely complex calculations. This patented algorithm finds solutions to control problems very quickly orders of magnitude faster than previously possible. |
Debug/Optimize/Secure, Urbana-Champaign | |
| Role of IG20 Splice Variants in Cell Growth and Death |
Cancer is one of the leading causes of death throughout the world. Curing cancer has been a major goal of medical researchers for decades, but development of new treatments takes time and money. Recent knowledge on apoptosis has made it possible to devisenovel approaches which exploit this process of cancer treatment. Furthermore, the majority of chemotherapeutic agents as well as radiation utilize the apoptotic pathway to induce cancer cell death. |
ALL OF THESE, ALL OF THESE, Chicago, NONE OF THESE, NONE OF THESE, Oncologic, Gene expression, regulation and signal transduction, Gene and Cell Therapy, Genomics/proteomics, Therapeutic | |
| Safety Training Inert Firearm |
It is a critical for police officers to place their fingers above the trigger along the frame of the gun when they are not ready to shoot. However, during training, it is difficult for instructors to tell if the trainee's finger is positioned correctly.
This device can be added to an inert firearm to show whether the trainee is placing his or her finger at the correct position. |
Other, Urbana-Champaign | |
| Saffold Virus -2 modified to propagate in mammalian cells |
Saffold
viruses (SafV) were discovered as a new group of human cardioviruses in 2007,
and are closely related to Theiler’s murine encephalomyelitis virus (TMEV),
which virally induces paralysis as well as encephalomyelitis comparable to
Multiple sclerosis in mice. In contrast to TMEV, which is monotypic, SafV
are geneticallydiverse including eight distinct genotypes. Most genotypes are difficult to propagate in
mammalian cells, and thus, detection of SafV is rare. However, using an unconventional quantification
method one study found three-fourths of adults were ser |
Chicago | |
| Sarcoidosis Diagnostic Kit |
Current
sarcoidosis diagnosis procedures can be time consuming, including a medical
history evaluation, physical exam, chest x ray, lung function test, and biopsy. A more efficient proceedure would include diagnostic
tools and biomarkers that identify patients likely to develop progressive
declines in lung function or extra pulmonary manifestations such as cardiac or
neurologic sarcoidosis. Experimental
data indicates that the proposed PBMC expression profile can be used in
diagnosing complicated sarcoidosisin human subjects.
|
Chicago, Server | |
| Scalable Peer-to-Peer Streaming Protocol for Real Time Data |
Current direct real time streaming implementations on the internet are limited by bandwidth consumption. Peer-to-Peer streaming reduces server bandwidth requirements, but it is vulnerable to delay and reliability issues that multiply as the network scales in size. Current Peer-to-Peer streaming implementations do not scale well and are not robust This scalable Peer-to-Peer protocol uses an elegant network formation and maintenance algorithm that minimizes the issues of peer churn, bum peers, and delay, providing for maximum theoretical scaling. |
Telecom, Urbana-Champaign | |
| Scour Sensor | Chicago, Civil, Mechanical and Industrial | ||
| Screening kit for increased lactation in US Holsteins |
This technology is a new method for the genetic screening of dairy cattle. Researchers at the University of Illinois, in collaboration with Israeli dairy researchers, have isolated a single nucleotide polymorphism (SNP) on the Bovine ABCG2 gene in Holstein Cows which increases the fat and protein content of milk.
Using a DNA test kit, farmers can quickly and easily isolate the "super-producers" within their herd. Once the cattle have been identified, farmers can use selective breeding to increase the overall net production of their cows. |
Food processing, Urbana-Champaign | |
| Selectable Markers and Promoters for Environmentally Friendly Plant Tissue Culture Transformation |
This DNA-based technology provides a novel, selectable marker gene and promoter for producing transgenic plants with heightened levels of tryptophan (Trp). |
Urbana-Champaign, Marker, Diagnostic hardware/software/medical devices, Genomics/proteomics, Research Tools and Reagants | |
| Selective Apoptotic Induction in Cancer Cells |
In cancer, the signaling cascade for programmed cell death, apoptosis, is often mutated leading to resistance from natural pro-death signals. PAC-1 and related compounds are small molecules capable of specifically killing cancer cells by inducing apoptosis. It does so by targeting an inactive apoptotic precursor, procaspase-3, that is up regulated in many cancer types. In vitro and in vivo studies have shown PAC-1 to be efficacious in reducing tumor cells at doses that show no toxicity in normal counterparts. |
ALL OF THESE, Oncologic, Urbana-Champaign, Anti-inflammatory, Immunotherapy, Drug delivery, Therapeutic | |
| Selective Inhibitor Treatment for Cardiovascular Disease Related Sudden Death |
In 2010, heart disease will cost the United States $316.4 billion. This total includes the cost of health care services, medications, and lost productivity. In 2006, heart disease caused more than one in every four deaths in the United States. Heart failure alone affects 4.7 million Americans, 1.5% of the total population. Sudden cardiac death is the largest cause of natural death in the United States, causing about 325,000 adult deaths in the United States each year. |
Chicago | |
| Self-Aligning Mechanism for Uniaxial Tests at Micro-Nano Scale and Method for in situ Mechano-Electrical Measurements of Micro-Nano Scale Specimens |
Current
methods of performing tensile tests on micro-nano scale material samples have
an inherent flaw, namely that true uniaxial loads are difficult to
achieve. Part of this stems from the
adaptation of macro-scale testing methods to the micro-nano scale, which has
been shown to be inadequate.
Accordingly, the instant technology seeks to achieve true uniaxial loads
on micro-nano scale material samples to achieve more reliable test results. |
Micro/nano scale, Urbana-Champaign | |
| Self-Assembled Nanometer Scale Lipid Bilayers for Drug Discovery and Therapeutic Delivery |
One of
the most challenging problems in biochemical science are studies that involve
membranes, including small molecules and proteins which are associated with
these cellular structures. |
NONE OF THESE, NONE OF THESE, Urbana-Champaign, Therapeutic | |
| Self-assembled Nanostructured Thin Films for Photovoltaic and Photosensing Devices |
A novel photovoltaic cell design utilizing a nano-textured silicon surface demonstrates promising performance as a new solar cell. |
Urbana-Champaign | |
| Separate Lateral Confinement Quantum Well Heterostructure Laser |
This technology maximizes a semiconductor laser's optical mode overlap and injected carriers. The semiconductor laser's optical mode overlap is optimized with the gain to produce lasers with lower threshold currents than standard ridge waveguide (RW) lasers.
A separate lateral confinement (SLC) structure creates a clear reduction in lasing threshold that is possible because of confinement of the injected carriers. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Serum Albumin Docking Sequence in Myeloperoxidase |
The transport of fatty acids, steroids, thyroxine, and amino acids across
the endothelial barrier is regulated by the plasma protein albumin. Albumin binds to albumin-binding proteins
localized in caveolae and the caveole transport albumin across the endothelial
barrier. Caveole are essential for
albumin transport and are a key determinant of transcellular endothelial
permeability. |
Chicago, Drug delivery | |
| ShadowLight-Mirage...a new era in visual communication. Immerse yourself in the virtual future. |
ShadowLight-Mirage is a software application that lets users create and explore fully immersive worlds in virtual reality. Space itself becomes the design medium, encouraging artistic innovation and accelerating the design process.
Rather than restricting users to traditional systems - fixed set of artistic or construction-centric tools, ShadowLight provides a novel degree of flexibility by supporting a plug-in architecture that allows the designer to utilize high-level components as the design media. |
Graphics/Visualization/Image, Urbana-Champaign | |
| Signal Transduction: G Protein Coupled Receptor |
Currently Gαs proteins are labeled with green fluorescent protein (GFP) at either the C- or N-t |
Chicago, NONE OF THESE, NONE OF THESE, Cell signaling, Research Tools and Reagants | |
| Signal Transduction: G Protein Coupled Receptor Fully Functional GFP Labeled G Proteins |
Currently Gαs proteins are labeled with green fluorescent protein (GFP) at either the C- or N-t |
Chicago, NONE OF THESE, NONE OF THESE, Cell signaling, Research Tools and Reagants | |
| Silencing of TGF-2 receptor expression by siRNA | Cardiac, Chicago, Ocular, Research Tools and Reagants | ||
| Simple, catalytic DNA biosensors for effective detection of heavy metals & other diverse analytes based on color changes |
Researchers at the University of Illinois at Urbana-Champaign have developed a new technology capable of effectively detecting and quantifying metal ions in a sample by color changes. Accurate, versatile, and inexpensive, this technology uses the catalytic DNA-directed assembly of gold nanoparticles and its associated color changes to determine the presence and concentration of a particular metal ion. The sensor works like a pH paper and yet can detect a diverse range of analytes. |
Urbana-Champaign, Water | |
| Simple, Sensitive, Selective Colorimetric Sensor for the Detection of Gaseous Formaldehyde |
Current
sensors employed in the detection of gaseous formaldehyde lack the ability to
detect formaldehyde at low concentrations.
Those sensors that can perform this task oftentimes take long periods of
time to detect the substances and are overwhelmingly expensive to employ. Additionally,
upcoming OSHA and WHO regulations will require that sensors are able to detect
significantly lower quantities of formaldehyde. |
Sensors | |
| Simplify with Microstructured semiconducting objects |
This technology is a powerful new route to the manufacturing of high performance thin film transistors on plastic substrates. Free standing micro and nanoscale objects of single crystal silicon can be fabricated from bulk silicon or silicon on insulator wafers by lithographic patterning of resist, etching of the exposed top silicon, and removing the underlying SiO2 to liftoff the remaining silicon. This form of "top down" microtechnology represents an attractive route to high performance flexible electronic systems. |
MEMS Devices, Urbana-Champaign | |
| Simultaneous Collection and Processing for the Study of Fluorescence and Phosphorescence via a Digital Frequency Domain Fluorometer |
Fluorometers provide very useful kinetic information on structures and chemical activities of biological entities, such as cells, biomolecules, and bacteria; therefore, they are widely used as analyti |
ALL OF THESE, ALL OF THESE, NONE OF THESE, NONE OF THESE, Urbana-Champaign, Spectroscopy, Research Tools and Reagants | |
| SiRNA Delivery Vehicle: Keeping Cartilage Healthy |
siRNAare involved in the silencing of select genes, or RNA interference (RNAi). There are issues with delivering the siRNA to the targeted sites in
vivo, and once the delivery problem is resolved, the
siRNA is also problematic in that the knock-down does not always occur or the
efficiency of the knock-down is not as high as needed. TNF-α or Tumor Necrosis Factor-α is a
cytokine that is involved in systemic inflammation and the degradation of
cartilage. UIC investigators have
designed a cationic peptide conjugated hydrogel as a vehicle to deliver a T |
Chicago, Rheumatologic, Skeletal, Drug delivery | |
| Smart Mesoflaps to Improve Performance of Supersonic Jet Engines |
Designed for use with supersonic aircraft, this invention efficiently, simply, and effectively controls shock/boundary-layer interaction (SBLI). SBLI is the interaction between supersonic shockwaves and the thin layer of air surrounding the aircraft (i.e., boundary layer). SBLI negatively impacts aircraft performance and longevity. This technology controls SBLI using an array of mesoflaps with a smart aeroelastic flap material. This variably deflecting array locally controls the boundary layer's thickness and shape factor and thus reduces shocks. |
Aerospace, Urbana-Champaign | |
| Smart Mesoflaps: Mesoflaps for shock/boundary-layer interaction control |
This new technology employs a mesoflap that dynamically optimizes performance and operation as flight operational conditions change. |
Urbana-Champaign | |
| SNP Mutations that Affect Milk, Fat, and Protein Yield in Cattle |
Nucleotides are the building blocks of DNA, which form the code for genes that determine physical characteristics and production traits in animals such as milk yield. When one of the nucleotides in DNA coding for a gene is replaced by another as a result of a mutation, a single nucleotide polymorphism (SNP) is formed. These SNPs can have drastic effects on the function of a particular gene, for example increasing susceptibility to certain diseases or increasing or decreasing potential production characteristics such as milk yield.
|
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Nucleic acid manipulation, Genomics/proteomics | |
| Solid-State Electrochemical Patterning of Copper and Gold: Homogeneous and Substitution Approaches |
Nano patterning, the ability to create nanometer scale features on a solid surface, has great potential as an energy-efficient approach in manufacturing. Solid state ionic conductors offer this possibility by exploiting highly localized electrochemical reactions at the point of contact between the conductor and a metal substrate. Metal ions migrate through the bulk of the ionic conductor toward the counter electrode under the influence of an electrical bias between an ionic conductor (stamp) and a metal surface (anode). |
Processes, Urbana-Champaign | |
| Sonosynthesis of multi-walled hydrocarbon nanotubes on silicon nanowires and its use as hydrogen storage medium under ambient conditions |
It is well known that hydrogen is a cleaner energy than fossil fuel, offering high energy efficiency with no pollution. |
Chicago, Micro/nano scale (non-electronic) | |
| Soybean Aphid Resistant Gene |
Researchers at the University of Illinois at Urbana-Champaign and United States Department of Agriculture - Agricultural Research Service (USDA-ARS) have discovered a gene for soybean aphid resistance in the soybean cultivars Dowling and Jackson. The soybean aphid was identified in the Midwestern United States as a significant infestation in July of 2000 and has since expanded to twenty-one states and other parts of North America. |
Crops and Germplasm, Urbana-Champaign | |
| Soybean Promoter Can Be Used to Increase Disease- and Pest-Resistance Without Affecting Seeds |
This newly isolated and sequenced promoter from the soybean Msg gene is preferentially active in the soybean pod, not in the seeds. It can be used in the genetic engineering of plants in the legume family for improved disease resistance traits without creating any adverse byproducts in the seeds.
Not only can this gene be used to prevent crop yield loss due to disease and pests, but also to increase the control and precision with which further improvements can be engineered into legume crops. |
Crops and Germplasm, Urbana-Champaign | |
| Specially Designed Molecular Sensors for In Situ Quantitative Imaging of Cellular Lipids |
Membrane lipids control diverse cellular processes, including cell proliferation, metabolism and apoptosis. Perturbation of the complex signaling networks formed by lipids and their targets can contribute to diseases, like cancer, diabetes and inflammation.
Determination of lipid spatiotemporal fluctuation and dynamics is a key step towards greater understanding of lipid-mediated processes. Unfortunately, current methods are neither quantitative nor highly specific. |
Chicago, NONE OF THESE, NONE OF THESE, Biosensors | |
| Specific knockdown of non-muscle myosin light chain kinase by siRNA |
Smooth muscle disorders contribute to many diseases, such as hypertension and asthma. Smooth muscle contraction/relaxation cycles require reversible phosphorylation of myosin regulatory light chain by myosin light chain kinase (MLCK) and myosin phosphatase (MLCP). Activation of MLCK (myosin light chain kinase) is known to be involved in cell migration, wound healing, and cell proliferation. In endothelial cells, MLCK activation results in barrier dysfunction in response to inflammatory mediators such as thrombin and histamine. |
Chicago, Pulmonary, Respiratory, Cell Biology, Research Tools and Reagants, Therapeutic | |
| Splice Site Prediction Using Inhomogeneous Markov Chain and Neutral Network |
UIC inventors have proposed a new splice site prediction method using inhomogeneous Markov chain model, combined with three-layer feed forward Neural Networks. |
ALL OF THESE, ALL OF THESE, Chicago, Nucleic acid manipulation, Genomics/proteomics, Research Tools and Reagants | |
| State-of-the-art surveillance with the SAC - self-aiming camera |
SAC is a moveable video camera whose unique software enables it to receive and process input from multiple sensors, then automatically aim itself at a target that is the most probable source of that i |
Security, Urbana-Champaign | |
| Stem Cell Immune Modulation and Its Molecular Mechanisms |
In this discovery,
UIC inventors detail molecular mechanisms underlying the immune modulation: 1)
Blood stem cells express autoimmune regulator (a transcription factor related
to the induction of immune tolerance) contributing the immune modulation; 2)
Blood stem cells display a certain peptidase contributing the immune modulation;
3) Expression of the transcription factor in blood stem cells contribute to the
peptidase gene modulation, as demonstrated by siRNA knock-down experiments.
|
Chicago | |
| Sub-10 nm fabrication: molecular templating, electron-beam sculpting and crystallization of metallic nanowires |
This technology provides a technique for fabricating metallic structures with dimensions considerably smaller than 10 nm and the use of a focused electron beam to locally manipulate nanowires with a resolution of about 3 nm. This is the first technology to use an electron beam and achieve such a high resolution of matter manipulation. |
Processes, Urbana-Champaign | |
| Sulfated phosphatidylinositols, their preparation |
Drug delivery systems are a key to the efficacy of any treatment. In recent times several mechanisms |
Chicago, Drug delivery | |
| Superconformal Chemical Vapor Deposition |
Manufacturers can not achieve superconformal (bottom-up) filling of high aspect ratio features by a modified chemical vapor deposition method. The CVD precursor flux is augmented by a small flux of a growth suppressor, which slows deposition near the upper surface of the substrate while permitting growth at normal rates deep in a trench or via. |
Processes, Urbana-Champaign | |
| Superhydrophobic, sprayable coating for stretchable surfaces |
Nitrile rubber (NBR) is a hydrophobic, solution processable rubber, and it is used extensively in the automotive industry (seals, fuel, oil hoses, etc.) for its low production costs, excellent thermal stability and chemical resistance. The use of NBR in nanocomposites as a matrix for ceramic and CB nanofillers has also been studied at length. |
Chicago, Energy, Environmental Sciences and Materials |
|
| Supramolecular Assembly for Non-Viral Gene Delivery |
Gene
therapy is an approach for human disease treatment. This is done by inserting
nucleic acids into cells to produce proteins, fix or replace damaged genes, and
inhibit expression of harmful genes.
The
gene delivery systems are classified into viral and nonviral systems. There are several advantages in nonviral
delivery systems, including biological safety (safer than viral vehicle), low
immunogenicity, ability to deliver large genes, and large scale production at a
reasonable cost. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Gene and Cell Therapy | |
| Synergistic drug delivery system (SDDS) to control pharmacokinetics and pharmacodynamics for diagnosis and treatment of complex diseases |
For extremely complex heterogeneous diseases, such as cancer, delivery of a single therapeutic agent or a simple combination of multiple therapeutic agents is not an efficient method of treatment. The limitation of many single-target therapies can be overcome by attacking the disease system on multiple fronts. Indeed, the combination of multiple component drugs is now standard for the treatment of complex diseases, such as cancer, diabetes, and infectious diseases. |
Chicago, Drug delivery | |
| TapeChanger::MTX-1.01 |
TapeChanger::MTX-1.01 is a module to manipulate a tape library using the "mtx" tape library program. It is meant to work with a simple shell/perl script to load and unload tapes as appropriate, and to provide an interface for more complicated programs to do the same. It comes with a few basic scripts to exercise much of the functionality of the module. Full documentation is provided within the source code.
More on TapeChanger::MTX-1.01
http://www.ks.uiuc.edu/Development/MDTools/tapechanger-mtx/ |
Software, Urbana-Champaign |
|
| Targeted Delivery of Liposomes Enhances Drug Efficacy | Chicago, Drug delivery | ||
| Targeted Drug Delivery of Pain Therapeutics via Sensory Neuron Specific Markers | ALL OF THESE, Analgesic, Chicago, Pain, Therapeutic | ||
| Temperature Independent pH (TIP) buffers for use at low temperatures |
Researchers and practitioners in university, industrial and national labs increasingly rely on low temperatures in the development and study of products. |
Urbana-Champaign | |
| Temporal Release of Growth Factors from 3D Microrod Scaffolds for Tissue Regeneration |
The present invention provides a versatile microrod-Matrigel composite system that can modulate the local microenvironment of ce |
Chicago, Cellular Engineering, Drug delivery | |
| Test Methods and Kits for Identifying Resistance or Susceptibility to Bovine Leukemia Virus (BLV)-Induced Persistent Lymphocytosis (PL) |
This technology provides an accurate means for determining whether a cow is resistant to or susceptible to persistent lymphocytosis (PL). |
Urbana-Champaign, Cell Biology, Cell signaling, Research Tools and Reagants | |
| Textureshop: Scratching a new surface in photo editing |
Textureshop has created a new photo editing tool that combines existing techniques for shape-from-shading and texture synthesis to enable a user to texture objects in a photograph.
|
Graphics/Visualization/Image, Urbana-Champaign | |
| The Geochemist's Workbench |
The Geochemist's Workbench (GWB) is a robust module-based software program that provides fast graphical solutions for manipulating chemical reaction calculations, calculating stability diagrams and equilibrium states of natural waters, tracing reaction processes, and plotting the results of these calculations. Considered the industry standard, this program is easier to use and faster than other programs of its type and saves significant time and steps for those in the geochemistry field. |
Soil & water models, Urbana-Champaign | |
| The University of Illinois at Chicago Antibody Research Tools Catalog |
The University of Illinois is actively seeking corporate partners to commercialize research antibodies developed in the laboratories of university faculty. Many of these antibodies have been validated in the laboratory and highlighted in journal publications. Companies currently marketing antibodies are particularly encouraged to review the online catalog which can be downloaded at the bottom of the page. |
Chicago | |
| The University of Illinois at Chicago Research Tools and Reagents Catalog |
The University of Illinois is actively seeking corporate partners to commercialize research tools and reagents developed in the laboratories of university faculty. Many of these reagents have been validated in the laboratory and highlighted in a journal publication. |
ALL OF THESE, ALL OF THESE, Chicago | |
| Therapeutic Scheme for Human Basigin |
Cancer researchers are focusing their efforts on identifying central pathways that trigger or enhance the invasiveness of tumor cells. One such target is EMMPRIN (Extracellular Matrix Metalloproteinase Inducer). It has been shown that EMMPRIN expression is linked to various cell signaling pathways that lead to an increase in tumor cell vascularization. Researchers are focusing efforts on elucidating the role of EMMPRIN in a number of disorders including cancer, arthritis, tissue repair and numerous inflammation-dependent diseases. |
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Angiogenesis, Angiogenesis, Therapeutic | |
| Time-Efficient Phase Error Correction in EPI-PROPELLER |
Periodically Rotated Overlapping ParallEL Lines with
Enhanced Reconstruction (PROPELLER) MRI is a widely used method to correct for
patient motion. Although echo planar imaging
(EPI) based PROPELLER is a more robust technique compared to fast spin echo
(FSE) based PROPELLER, EPI-PROPELLER suffers from Nyquist ghosts which
necessitates phase correction. |
Chicago, Software, Imaging | |
| Tissue Factor (TF) Nanodisc |
This technology marries the Recombinant Human Tissue Factor (TF) with Membrane Scaffold Protein (MSP) NanodiscsTM, resulting in an efficient and easy to administer blood c |
Genetic, Nervous, Neurologic, Urbana-Champaign, Anesthetic, Proteins, Gene and Cell Therapy, Immunotherapy, Genomics/proteomics, Therapeutic | |
| Tolerogenic biodegradable artificial antigen presenting system for the treatment of autoimmune disease and transplant rejection |
Understanding complex immunological processes at the molecular level will give investigators and cli |
ALL OF THESE, Autoimmune, Chicago, Pulmonary, Immunotherapy, Therapeutic | |
| Track and Trace Agricultural Grains With A Whole New Level of Sophistication Using This RFID System Approach |
This invention is a system to track agricultural grain from harvest to the final "whole" grain point in the supply chain process; end users or processors. System components include radio frequency identification device "Grain Chips"(RFID-GC); technology to systematically deposit and remove RFID-GC; hardware, software, and software database storage. |
Agricultural Engineering, Urbana-Champaign | |
| TrafficMedia -- An Efficient Multimedia Traffic Information System to Assist Drivers about Traffic Jams and Road Hazards |
The
application of mobile wireless communication technology to provide traffic
information can help answer questions, such as whether to take the next exit
off an interstate highway or to continue driving. There has been a growing interest of consumer
demand for applications that can present a driver with real-time, dynamic
traffic and navigation information. |
Chicago | |
| Training Program for Fall Prevention |
The current UIC invention is a novel method of training for fall prevention. |
Assistive device, Chicago, Therapeutic hardware/ software/medical devices | |
| Transcorneal telescope (KSCOPE) as a visual aid for vision impairment due to eye disease such as age related macular degeneration |
The number of Americans with disabling eye disease is increasing due to an aging population. Blindness or low vision affects 3.3 million Americans age 40 and over. This figure is projected to increase to 5.5 million by the year 2020. This invention is implantable telescopic lens used for individuals requiring visual aid. The transcorneal telescopic lens allows for up to 6X magnification of images to the retina with the advantage of having a stable scaffold for long term retention and the benefit of not depending on endothelial cell health. |
Chicago, Ocular, Ophthalmalogical, Invasive device, Therapeutic hardware/ software/medical devices | |
| Transdermal Breast Cancer Therapy Enhanced by Dendrimers |
Estrogens have repeatedly been shown to stimulate the growth of breast cancers. Tamoxifen (TAM) metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen (ENX) modulate estrogen receptor (ER) expression. However, oral dosages of TAM may be responsible for unwanted side effects that have been observed during the use of these compounds in medical treatments. Side effects include thrombo-embolism, uterine cancer, and quality of life impairment through hot flashes and vaginal atrophy. |
Chicago, Oncologic, Reproductive, Drug delivery | |
| Transformation of Critical Crops to Engineer Improved Stress and Yield Characteristics |
Numerous types of stresses (heat, cold, drought, insects, high salinity in soils, UV radiation) decrease the yield of important commercial food crops. UIC researchers have found a critical, early stage of the phenylpropanoid metabolic pathway that can enhance a crop’s tolerance to plant stresses. Phenylalanine is an aromatic amino acid and essential for cellular function. Administration of additional phenylalanine at an appropriate time has been shown in both a model organism and in soybean to significantly affect resistance to stress and can improve seed yield. |
Chicago, Food | |
| Transport Communication Tool with Oxygen Cylinder |
The present invention is related to a transport communication tool with oxygen cylinder assessment. The tool comprises a grid that provides simplicity and accuracy in the assessment of oxygen cylinder. The oxygen cylinder assessment tool utilizes universal colors, red, yellow, and green, to reinforce appropriate use of the oxygen cylinder for transport. In addition, the tool is embedded in a process that utilizes the primary source of patient information, the electronic medical record (EMR) and requires peer accountability for patient & oxygen assessment prior to transportation. |
Chicago | |
| Treatment for Diastolic Dysfunction |
Heart
failure is the leading cause of hospital stays for those over the age of
65. The need for therapeutic and
diagnostic methods for this condition will only increase as the elderly
population continues to grow. Diastolic
dysfunction with preserved left ventricular function is a condition where
abnormal stiffening of the heart ventricles leads to abnormal filling of the
ventricles during their relaxation period.
As the condition advances, fluid extravasates into the lungs, and the
situation is elevated to diastolic heart failure (DHF). DHF is associa |
Chicago | |
| Treatment for Diastolic Dysfunction |
Heart failure is the leading cause of hospital stays for those over the age of 65. The need for therapeutic and diagnostic methods for this condition will only increase as the elderly population continues to grow. Diastolic dysfunction with preserved left ventricular function is a condition where abnormal stiffening of the heart ventricles leads to abnormal filling of the ventricles during their relaxation period. As the condition advances, fluid extravasates into the lungs, and the situation is elevated to diastolic heart failure (DHF). |
Chicago | |
| Treatment Method for Salt-Sensitive Hypertension |
Affecting 50 million Americans and over 500 million people worldwide, hypertension is the most commo |
Cardiac, Chicago, Circulatory, Hematologic, Therapeutic | |
| Treatment of Diseases Caused by Bacterial Exotoxins |
Exotoxins and enterotoxins released by Staphyloccal aureus and Streptococcus pyogenes trigger massive release of inflammatory proteins (cytokines) by the immune system, which cause clinical problem |
Circulatory, Dermatologic, Integumentary, Pulmonary, Respiratory, Urbana-Champaign, Anti-inflammatory, Therapeutic | |
| Treatment Significantly Increases Conversion of Homocysteine to Methionine for Reducing Human Cardiovascular Disease (CVD) Risk and Use of Animal Feed Additives |
This treatment method and pharmaceutical composition could be significantly more effective at lowering the risk of hyperhomocysteinemia-related cardiovascular disease than traditional betaine treatmen |
Urbana-Champaign | |
| Tunnel Coupling Layer for Efficient Quantum Dot Lasers |
A major problem with quantum dot (QD) lasers is the stochastic nature of QD structures, the lack of uniformity, the insufficient QD density, and the poor QD-to-QD coupling. |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Tyrosine Phosphorylation of the Integrin B3 Subunit Regulates B3 Cleavage by Calpain |
Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases can be treated effectively and, theoretically, artificial tissues could be built. |
Chicago | |
| U of I Extension Online Registration and Payment Processing System |
Looking for a centralized system to help you process and keep track of registrations? The U of I Online Registration and Payment Processing System does that and allows you to now serve your customers with online registrations. It is easy and saves time and money. |
Business Software, Urbana-Champaign | |
| Ultra Low Power Multi-Constraint Physical Synthesis Tool |
Researchers at UIC have developed a low-power physical synthesis
(PS) tool DNF-PS for chip design. This
tool simultaneously applies a set of
very effective power/timing optimizing transforms (in particular, multiple Vdd, multiple Vth, cell sizing,
buffer insertion, cell replication and global re-placement), and does so
simultaneously
across the entire circuit while satisfying multiple constraints (e.g., on timing, voltage islands, area,
congestion). |
Packaging, processing | |
| Ultra-low thermal conductivity insulation |
Vacuum insulation is an advanced thermal insulation technology that significantly outperforms conventional materials. Typically, vacuum insulation is 3 to 7 times better than conventional insulation of polyurethane foam, polystyrene foam, and fiberglass batting. A vacuum insulation panel (VIP) is the most common embodiment of vacuum insulation, of flat or sometimes shaped structures that, when holding a vacuum (often in the range of 0.1 to 1 millibar), provides the resistance to thermal conduction. |
Chicago, Civil, Mechanical and Industrial | |
| Ultrathin Dielectric Oxide Films for Improved Passivation of Superconducting Materials |
This technology is a method of fabricating an oxide layer on the surface of a high-temperature (high Tc) superconductor. The oxide layer passivates the superconductor, preventing degradation via air and moisture and eliminating the need to store materials at low temperatures in controlled atmospheres. The oxide coating also permits higher resolution measurements of the electronic structure at the superconductor surface than was previously possible. The technology is useful in forming improved tunnel junctions and potentially Josephson tunnel junctions. |
Processes, Urbana-Champaign | |
| Ultrathin Dielectric Oxide Films on Silicon |
The technology is a chemical method for preparing ultrathin oxide films on silicon with low leakage currents and high capacitance, optimizing the electrical properties of the dielectric barrier. |
Processes, Urbana-Champaign | |
| Uniflow Aerodynamic Deduster for Air Cleaning |
This invention is a new form of no-contact dust separation technology designed to clean very dusty or polluted air with little maintenance and low energy costs, removing most of the harmful respirable particles smaller than 10 μm. |
Agricultural Engineering, Urbana-Champaign |
|
| Unique similarity of Angiotensin II sequence across species and its use in detecting apoptosis in all tissues and species |
Angiotensin II induces apoptosis in various cell types. Angiotensin II has been shown to be involved in both extrinsic (directly transducing the signal via adapter proteins to the apoptotic mechanisms) and intrinsic (targeting mitochondria functionality) mechanisms of apoptosis. Hence the technology proposes the use of angiotensin as a marker for apoptosis in all tissue types and in all species. Angiotensin II differs by only one amino acid across species. Hence it can be used as a universal marker for detection of apoptosis across all species, cell and tissue types. |
Chicago, Diagnostic biological tests/assays | |
| Universal Memory Architecture For Integrating Emerging Memory Technologies |
Current main memory system designs are severely limited by the traditional synchronous DRAM architecture. This architecture requires the memory controller to track the internal status of memory devices (chips) and schedule the timing of device operations. This rigidity has become an obstacle for integrating emerging memory technologies such as PCM into existing memory systems--PCM requirements are vastly different. |
Chicago, Networking/Data Transmission | |
| Unprecedented control of cofactor regeneration using Microfluidic Device that Performs Electrochemical Synthetic Reactions |
This microfluidic device is an electrochemical cell based on multi-stream laminar flow. It allows for specific control over reactions taking place at the electrodes. |
Urbana-Champaign | |
| Use of a Parasite-derived Novel Protein as an Anti-inflammatory and Immunomodulatory Agent |
A protein with anti-inflammatory and immunomodulatory functions was identified and isolated from the |
Chicago | |
| Use of eNOS inhibitor and/or agonist of protein kinase G for treatment of pulmonary hypertension |
The present invention is a medical invention related to a novel therapeutic strategy for the treatment of pulmonary hypertension. Pulmonary hypertension is continuous high blood pressure in the pulmonary (lung) artery, and may be either primary (unknown etiology), or secondary (due to chronic heart or lung disease, blood clots in the lungs, or scleroderma). Current treatment protocols for pulmonary hypertension are often complex and require multiple combination drug regimens in addition to extensive follow-up care. |
Chicago, Circulatory, Gene and Cell Therapy, Therapeutic | |
| Use of Specific Inhibitors of Protein Kinase C (PKC) Isoforms to Normalize Fast Axonal Transport Function in the Treatment of Familial and Sporadic Forms of Parkinson’s Disease |
The invention describes a molecular mechanism that leads to neurodegeneration in people with certain forms of Parkinson’s disease. |
Chicago, Nervous, Neurologic, Therapeutic | |
| Use of specific inhibitors of stress-activated protein kinases to preserve fast axonal transport function for the treatment of neurodegeneration in amyotrophic lateral sclerosis (ALS) |
Amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's disease," is a progressive n |
Chicago | |
| Use of specific inhibitors of stress-activated protein kinases to preserve fast axonal transport function in the treatment of polyglutamine expansion neurodegenerative diseases |
The polyglutamine expansion diseases include Kennedy’s Disease (Spinobulbar muscular atrophy), Hunti |
Chicago, Nervous, Neurologic, Therapeutic |
|
| Use of Specifically Engineered Enzymes to Enhance the Efficacy of Prodrugs |
A significant problem for cancer patients is that 40-50% of those diagnosed with cancer may develop resistance to anticancer drugs. Furthermore, those with advanced acute and chronic leukemia and lymphoma cannot be cured. Cancer chemotherapy involves a variety of clinically established treatments for malignant diseases. However, there are issues, such as an insufficient therapeutic index, a lack of specificity, and the appearance of drug-resistant cell subpopulations. One issue, in particular, is with anti-metabolites and nucleoside analogs (NA). |
ALL OF THESE, Chicago, NONE OF THESE, Oncologic, Therapeutic | |
| Using Dendritic Material as a Dry-Release Sacrificial Layer to Create Micro-Scale Gaps for MEMS |
This technology is a method for forming micro-scale gaps, such as those required between a suspended microstructure and an opposing surface in microelectromechanical systems (MEMS) fabrication, using dendritic material as a dry-releasable, sacrificial layer. The sacrificial layer can be applied to a surface by spin coating a solution of dissolved, dendritic material. After patterning and forming the desired microstructures, the sacrificial layer can be removed by heating the dendritic material past the point of decomposition, such that it vaporizes. |
Processes, Urbana-Champaign | |
| Using Organosilacyclobutanes to Form Carbon-Carbon Bonds without Toxic Byproducts |
Traditional methods for forming carbon-carbon bonds between unsaturated moieties have a number of well-known difficulties. |
Diagnostic biological tests/assays, Urbana-Champaign, Expression and purification, Immunoassay |
|
| Using Phosphorous to Diagnosis Disease using a novel MRI-based imaging technique and software |
The
magnetic resonance imaging (MRI) market was worth $858.2 million in 2008. MRI is critical for medical diagnosis of in a
number of disorders. MRI uses magnetism,
radio waves, and computational processing to produce images of body
structures. A magnetic field aligns the
protons of hydrogen atoms, which are then exposed to a pulse of radio
waves. As radio waves spin various
protons in the body, the protons emit a signal that is detected by the receiver
of the MRI scanner. Received information
is processed by a computer to produce an image.
Dr. |
Cardiac, Circulatory, Imaging, MR, Diagnostic hardware/software/medical devices | |
| UV and light protecting effects on plants of phenylalanine in various solutions |
UIC researchers demonstrated that phenylalanine in solution or in solution with other compounds confers UV shielding effects to the surface of plants or to other materials that are in the same mixture as the phenylalanine. |
Chicago, Food | |
| Vaccination strategy to eradicate the cycle of malaria transmission |
Currently, there is
no medication guaranteed to prevent malaria.
Thus, it is important to combine personal protective measures with drug
prophylaxis to achieve maximum protection. |
Chicago | |
| VaPRRS -Technology for Effective Air Quality Control |
The University's Vapor Phase Removal and Recovery System (VaPRRS) is a patented long-lasting filter that effectively removes dilute volatile organic compounds (VOCs) and hazardous air pollutants (HAPs) from gas streams and recovers them as pure liquids. The technology can be integrated into a variety of manufacturing facilities and air pollution control (APC) systems to make them more effective.
VaPRRS is a VOC/HAP recovery system that uses an activated carbon fiber cloth and electrothermal desorption (ED) to inexpensively and selectively remove vapors from gas streams. |
Air, Urbana-Champaign | |
| Ventricular Volume Sensor of the Brain |
Hydrocephalus is a condition marked by abnormal and excessive accumulation of cerebrospinal fluid (C |
Chicago, NONE OF THESE, NONE OF THESE, Invasive device, Therapeutic hardware/ software/medical devices | |
| Versatile and Simplified Production of High Surface Area-Small Particle Hydrated Limes |
This technology provides a simple, commercially practical method for preparing hydrated lime with high surface area, high porosity, and low particle size. |
Air, Urbana-Champaign | |
| Versatile Microdischarge Devices |
The University of Illinois at Urbana-Champaign is offering a suite of microdischarge technologies for license and/or joint development by qualified companies.
Microdischarge device technology involve |
Optoelectronics, Photonics and Lasers, Urbana-Champaign | |
| Video and thermal imaging system for monitoring interiors of high temperature reaction vessels |
The proper flame controls within high temperature reaction vessels may provide enhanced efficiency, environmental performance, and reliability. The proposed invention involves low-cost video and thermo imaging systems allowing real time monitoring of temperature in high temperature reaction vessels and more specifically in combustion and gasification apparatuses. The invention utilizes color digital signals and calibration function for temperature recognition inside the reaction vessels. The thermal image is formed based on the temperatures acquired for each individual pixel. |
Chicago | |
| VIP as a Diagnostic Agent |
The biologically active form of Vasoactive Intestinal Peptide (VIP) incorporated into sterically sta |
ALL OF THESE, ALL OF THESE, Chicago, Diagnostic biological tests/assays, NONE OF THESE, NONE OF THESE, Biosensors |
|
| VIP as Therapeutic |
Vasoactive intestinal peptide (VIP) can be utilized in a wide variety of therapeutic uses. However, |
Chicago, Diagnostic biological tests/assays, Integumentary, Drug delivery | |
| VIP micelle and liposomal based formulations for eye disorders |
The major limitation to the use of Vasoactive Intestinal Peptide (VIP) and other amphipathic molecules as a therapeutic agent under normal physiological conditions is that the peptide is cleaved rapidly by enzymes and its effects are usually weak and very brief, which requires administration of large amounts over extended periods. Water insoluble drugs, exemplified by testosterone and the anti-cancer drug, Taxol may precipitate after intravenous administration. These agents might require larger doses which increases the risk of possible deleterious side effects. |
Chicago | |
| Visualization of Constitutive Relations and Stress and Strain Tensors in Mechanics (VIZCORE, http://cee.uiuc.edu/vizcore/) |
In this technology, advanced constitutive relations are used in engineering mechanics to simulate measured material behavior in the laboratory, and in analytical models (finite elements/difference).
The software transforms the representation of constitutive relations, as well as stress and strain quantities from a series of mathematical equations and matrix quantities to multidimensional geometric/visual objects in a dynamic, interactive display environment. |
Soil & water models, Urbana-Champaign | |
| Wastewater/Groundwater Treatment Improves Destruction of Oxidation-Refractory Contaminants |
Compared to currently available oxidative processes, this reductive water treatment process dramatically improves the efficiency of treatment for nitro-containing compounds (e.g., ordnance and energetic compounds); halogenated compounds (such as CCl4); and others containing electron-withdrawing substituents such as sulfonate, nitrile, and carboxylate. It is a cost-effective treatment that can be added to existing oxidative water treatment processes. |
Urbana-Champaign, Water | |
| Water Purification Using Ion Exchange Resins and Electric Fields: A Cost Effective Alternative to Reverse Osmosis |
Removal
of impurities using ion exchange resins is currently a well developed
technology. For example, it is widely
used in water softening where zeolites are
used for reduce water hardness. In
addition, ion exchange resins are used to replace the sodium and chloride ions
in sea water with an equivalent number of protons and hydroxy groups that then
combine to form water. Efficient methods
are available to regenerate these resins either thermally or, in some cases,
chemically. The main hu |
Chicago, Environmental Testing and Remediation | |
| Water Resistant Metal-Organic Frameworks |
The construction of nanoporous metal-organic frameworks (MOF) by copolymerization of organic molecules with metal ions has received widespread attention in recent years. |
Urbana-Champaign, Water | |
| WaveTracker 3D: Speed and Accuracy in Detonation Shock Wave Modeling |
Accuratelymodeling detonation shock fronts is a critical challenge for explosiveengineers in aerospace, defense, mining, drilling, and demolition. Currently available level set-based modelsuse a computationally intensive process to model every point on a definedplane, resulting in extreme accuracy at speeds so slow that many users neverrun high resolution models at all. Particle-based models run more quickly, but are difficult to implementand likely to miss splits and merges in the wave front. |
Chemistry and Physics, Urbana-Champaign | |
| Web Portal Framework – Media Aggregation and Analysis for the Open Web |
As
consumers increasingly turn to online sources for news and information, news
portals play an important role in aggregating, analyzing and selecting news to
publish. To maintain relevance amid the
growing influence of social media and “open web” sources, these news portals
must extend their reach to include content from blogs, vlogs, tweets, and other
new media. |
Business Software | |
| Wireless Deep Brain Stimulation (DBS) to reduce tremors in Essential Tremor and Parkinson’s Disease |
Deep
brain stimulation is used to control unwanted tremors in patients with
Essential Tremor disorder or Parkinson’s disease. Currently, the stimulus is continuous and can
only be turned on or off. Over 100,000
people in the U.S. have neuronal implants to control tremors currently. |
Chicago, Nervous, Neurologic, Therapeutic hardware/ software/medical devices | |
| Wireless Personal Elevator Control | Civil, Mechanical and Industrial, Urbana-Champaign |
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| “From Morning ‘Til Night: Programming in Residential Facilities” |
This workbook was designed for residential youth facility staff who work with emotionally and behaviorally disturbed residents. The workbook contains information on how to run effective milieus and programming and also includes activities to use with youth. |
Chicago |