Preventing Inflammation-Induced Pulmonary Vascular Leakage
Sepsis poses a significant health risk in the United States, with an estimated 750,000 severe cases annually. Studies estimate the overall hospital mortality rate for sepsis to be 14-29%, while another study found confirmed severe sepsis in 6.3% of intensive care unit patients, with an associated mortality of 56%. With an average cost of over $22,000 per case, the total annual costs due to severe sepsis were estimated to be $16.7 billion. Sepsis does not have a cure and currently only one drug has FDA approval for the treatment of severe sepsis.