Matricellular Scaffold Modulators for Regeneration of Periodontal Tissues
Periodontal disease is one of the major reasons for tooth loss in the United States and may be associated with systemic effects, including heart disease and rheumatoid arthritis. Although tooth retention has greatly improved over the past few decades, a significant percentage of older Americans do not have functional dentitions and only 42.4% of the U.S. population aged 50 years and older have 21 or more natural teeth. The consequences of severe periodontitis are increased tooth motility and ultimately tooth loss. One approach towards fighting periodontal disease involves the replacement of lost periodontal tissues with new tissues matching the structure and function of oral tissues such as the gingiva, the root cementum and the alveolar bone. The 95% of Americans suffering from periodontal disease are now more than ever seeking alternative methods for treating their ailments while maintaining their natural teeth.