Technologies
Proteins
Bipolar disorder is a devastating psychiatric condition that affects approximately 3 million persons in the US. It is characterized by mood disorders that range from episodes of abnormally elevated energy levels, and intense cognition followed by transient depressive states. The disease usually manifests in late adolescence or early adulthood. The extreme manic phases of the disease can be accompanied by psychotic delusion and hallucinations.
S100 proteins are small calcium-binding proteins that are found at high levels in the extracellular milieu during inflammatory conditions. The UIC inventor has discovered that these proteins possess significant anti-inflammatory and anti-hypoxic activity. It was also shown that S100 proteins inhibit the activation of peripheral neutrophils by activating a specific type of PKC known for its anti-inflammatory activity, and have a protective effect against hypoxia.
An estimated 300 million to 500 million cases of malaria occur worldwide annually. Approximately 2.7 million people die as a result of malaria each year.
A sub-population of CD4+ T-cells that express CD25 has been identified for its crucial role in the physiological control of autoimmunity and is referred to CD4+CD25+ cells. These cells account for a small percentage of the normal CD4+ T-cells. The discovery of CD4+CD25+ cells has lead to a flurry of investigations to utilize these cells to control undesired responses of T-cells against beneficial foreign antigens. The current invention leverages CD4+CD25+ cells in a way that surpasses any prior art for tolerizing the immune system for specific antigen suppression.
In the last decade the incidence of thrombo-embolic diseases in which anti-platelet drugs may have been beneficial was estimated to be 2,500,000 patients affected by coronary artery diseases, 873,000 patients with cerebrovascular disease, i.e., stroke or transient ischemic attack, and 2,000,000 patients with peripheral arterial occlusive disease. The interaction between the platelet glycoprotein (GP) Ib-IX complex and von Willebrand factor (VWF) is known to initiate both hemostasis and pathological thrombosis, particularly in arteries and capillaries.
ALL OF THESE, ALL OF THESE, Urbana-Champaign, Cell Biology, Gene expression, regulation and signal transduction, Anti-inflammatory, Marker, Molecular Biology, Drug Design, Drug targets, Proteins, Immunotherapy, Drug delivery, Genomics/proteomics, Sythesis and Analysis, Research Tools and Reagants, Therapeutic
This technology marries the Recombinant Human Tissue Factor (TF) with Membrane Scaffold Protein (MSP) NanodiscsTM, resulting in an efficient and easy to administer blood c
These patent-pending optical contrast agents and molecular detection technologies were developed to enhance the ability of optical coherence tomography (OCT) to non-invasively map molecules in living specimens and diagnose disease where it starts. OCT utilizes low-coherence interferometry to measure the intensity of reflected or backscattered light to form images with micrometer resolution, is readily integrated with existing optical instrumentation and has application across a wide range of biological, medical, surgical, and non-biological specialties.
ALL OF THESE, ALL OF THESE, Assistive device, Circulatory, CT, Diagnostic biological tests/assays, Hematologic, NONE OF THESE, NONE OF THESE, Urbana-Champaign, Imaging, Biomaterial, Gene expression, regulation and signal transduction, Invasive device, Marker, Diagnostic hardware/software/medical devices, Molecular Biology, Drug Design, Proteins, Enzymes, Genomics/proteomics, Sythesis and Analysis, Research Tools and Reagants