Technologies

Molecular Biology

Advanced molecular imaging tools combinedwith investigative tools like biochemical and cell based assays have thepotential to unravel complex molecular processes. These tools combined withhigh throughput screening can significantly impact diagnostics for cancerscreening and accelerate drug discovery. The present inventions are two new FluorescenceResonance Energy Transfer (FRET) biosensor pairs, one composed of two newcolors, mOrange2 and mCherry and the other composed of a modified high-sensitiveECFP/YPet pair that can significantly enhance the dynamic range of a variety ofbiosensors.
These patent-pending optical contrast agents and molecular detection technologies were developed to enhance the ability of optical coherence tomography (OCT) to non-invasively map molecules in living specimens and diagnose disease where it starts. OCT utilizes low-coherence interferometry to measure the intensity of reflected or backscattered light to form images with micrometer resolution, is readily integrated with existing optical instrumentation and has application across a wide range of biological, medical, surgical, and non-biological specialties.
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