Technologies
Sub Categories
Genomics/proteomics
Bipolar disorder is a devastating psychiatric condition that affects approximately 3 million persons in the US. It is characterized by mood disorders that range from episodes of abnormally elevated energy levels, and intense cognition followed by transient depressive states. The disease usually manifests in late adolescence or early adulthood. The extreme manic phases of the disease can be accompanied by psychotic delusion and hallucinations.
Advanced molecular imaging tools combinedwith investigative tools like biochemical and cell based assays have thepotential to unravel complex molecular processes. These tools combined withhigh throughput screening can significantly impact diagnostics for cancerscreening and accelerate drug discovery. The present inventions are two new FluorescenceResonance Energy Transfer (FRET) biosensor pairs, one composed of two newcolors, mOrange2 and mCherry and the other composed of a modified high-sensitiveECFP/YPet pair that can significantly enhance the dynamic range of a variety ofbiosensors.
This technology provides an effective means of control release kinetics for pharmaceuticals.
UIC inventors have proposed a new splice site prediction method using inhomogeneous Markov chain model, combined with three-layer feed forward Neural Networks.
Currently, it takes several years to gather reliable data for selecting genetically superior dairy cows or bulls for use in breeding programs using traditional methods.
Nucleotides are the building blocks of DNA, which form the code for genes that determine physical characteristics and production traits in animals such as milk yield. When one of the nucleotides in DNA coding for a gene is replaced by another as a result of a mutation, a single nucleotide polymorphism (SNP) is formed. These SNPs can have drastic effects on the function of a particular gene, for example increasing susceptibility to certain diseases or increasing or decreasing potential production characteristics such as milk yield.
S100 proteins are small calcium-binding proteins that are found at high levels in the extracellular milieu during inflammatory conditions. The UIC inventor has discovered that these proteins possess significant anti-inflammatory and anti-hypoxic activity. It was also shown that S100 proteins inhibit the activation of peripheral neutrophils by activating a specific type of PKC known for its anti-inflammatory activity, and have a protective effect against hypoxia.
An estimated 300 million to 500 million cases of malaria occur worldwide annually. Approximately 2.7 million people die as a result of malaria each year.
The present invention is a medical invention related to a novel diagnostic marker for cancer. In particular, it relates to studies investigating the expression profile of a pseudo MLCK gene. Myosin-light-chain kinase (MLCK) is a serine/threonine-specific protein kinase that phosphorylates the regulatory light chain of myosin II. It is of critical importance in regulating cytoskeletal dynamics by increasing myosin-actin crossbridge.
In the last decade the incidence of thrombo-embolic diseases in which anti-platelet drugs may have been beneficial was estimated to be 2,500,000 patients affected by coronary artery diseases, 873,000 patients with cerebrovascular disease, i.e., stroke or transient ischemic attack, and 2,000,000 patients with peripheral arterial occlusive disease. However, even though G protein signaling pathways are known to be intimately involved in the genesis of thromboembolic events, it has not been possible to pharmacologically target G proteins as a means of decreasing blood platelet functi