Technologies

Gene expression, regulation and signal transduction

The present invention is a medical invention related to a novel diagnostic marker for cancer. In particular, it relates to studies investigating the expression profile of a pseudo MLCK gene. Myosin-light-chain kinase (MLCK) is a serine/threonine-specific protein kinase that phosphorylates the regulatory light chain of myosin II. It is of critical importance in regulating cytoskeletal dynamics by increasing myosin-actin crossbridge.
Cancer is one of the leading causes of death throughout the world. Curing cancer has been a major goal of medical researchers for decades, but development of new treatments takes time and money. Recent knowledge on apoptosis has made it possible to devisenovel approaches which exploit this process of cancer treatment. Furthermore, the majority of chemotherapeutic agents as well as radiation utilize the apoptotic pathway to induce cancer cell death.
This technology is a short fragment of a naturally occurring peptide that can be used to regulate the density of calcium current in mammalian cells. Modulation of calcium current across cell membrane
These patent-pending optical contrast agents and molecular detection technologies were developed to enhance the ability of optical coherence tomography (OCT) to non-invasively map molecules in living specimens and diagnose disease where it starts. OCT utilizes low-coherence interferometry to measure the intensity of reflected or backscattered light to form images with micrometer resolution, is readily integrated with existing optical instrumentation and has application across a wide range of biological, medical, surgical, and non-biological specialties.
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