Counter-current chromatography (CCC) is a high resolution separation technique useful for fractionating complex mixtures, such as natural product extracts, under very mild conditions based on their relative solubility in two immiscible phases. Cross-platform comparison of CCC chromatograms is essential for the calibration, quality control, trouble shooting, and test performance of instruments, as well as rapid development of new CCC/CPC (Counter-partition chromatography) columns.