Foxm1b siRNA to Inhibit Tumor Cell Proliferation
Hepatocellular Carcinoma (HCC), also known as primary liver cancer or hepatoma, is a cancer that arises from the liver and accounts for 80% to 90% of all liver cancers. Occurring more often in men than women, HCC is mainly prevalent in people 50 to 60 years of age. Contributing factors to the disease include chronic liver disease, viral hepatitis (especially hepatitis B and C), alcohol consumption, fatty liver disease, hemochromatosis, hepatic carcinogens, and toxins. FoxM1B, also known as Forkhead Box (Fox) M1B, is a member of the family of Fox genes, found in all animals ranging from insects to mammals. FoxM1 transcription factor regulates expression of genes involved in controlling cell division. FoxM1B is required for both DNA replication and mitosis. In previous laboratory experiments, deletion of the FoxM1b gene was shown to prevent development of mouse liver cancer in response to chemical carcinogens. This led the researchers to believe that FoxM1B gene plays a role in promoting the growth of tumors in liver cancer as well as other types of cancer.