Biomimetic 3D Scaffolds for Bone and Dental Pulp Tissue Regeneration
Loss of dental and craniofacial tissues due to disease, injury or genetic disorders negatively affects the quality of life of millions of Americans. Presently, the gold standard in clinical treatment for craniofacial bone defects is autografts and demineralized bone matrix (DBM). Autografts perform exceptionally well, but are known to induce donor site morbidity and DBMs poorly induce regeneration of lost tissue. With respect to treatment for injury/trauma or loss of the dental pulp, current clinical procedure is to use fillers such as mineral trioxide aggregate (MTA) that do not permit regeneration of the lost pulp tissue. Tissue engineering has the potential to overcome these deficiencies. However, problems associated with growth factor delivery and control of stem cell behavior over time has proved to be a significant challenge.