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The research and level of innovation at the University has resulted in an impressive and balanced portfolio of technologies including everything from therapeutic treatments to new crop varieties, semiconductors to genetic algorithms, imaging agents to internet tools, and fuel cells to microfluidics.

Title Teaser Technology Numbers Inventor Name

Understanding the geometric, topologic, and mechanical properties of cells and their interactions is critical for studying tissue pattern formation and organ development. Although a number of computational tools exist, they do not account for detailed cellular shapes as well as dynamic changes in cell geometry and topology accurately.

Dr. Jie Liang and his lab have developed a new algorithm and software tool for simulating birth, death, growth, rearrangement, fusion, and pattern formation of cells with realistic shape.


DG161 Jie Liang
Methods for Reducing Chemical Shift Displacement Errors in 2D MR Spectroscopy (J-LASER and J-sLASER)

Magnetic Resonance (MR) spectroscopy is a non-invasive diagnostic test that measures biochemical changes in the brain to differentiate between different neurological conditions and tumor types.

DG090 Shaolin Yang
Method for Simultaneous Acquisition of 3D Displacement Data in MR Elastography (SLIM-MRE)

Manual palpation of the body for assessing pathologies represents one of the most effective traditional diagnostic methods. The sensitivity of manual palpation is rooted in the correlation of pathological changes with the mechanical behavior of biological tissue. Inside the body, the mechanical properties can be determined using the emerging technique of magnetic resonance elastography (MRE)

DG062 Dieter Klatt
Method for Reducing Fold-Over Artifacts in Magnetic Resonance Imaging

A “featherlike” artifact, termed a cusp artifact, is sometimes seen along the phase-encoding direction in sagittal or coronal fast spin echo images. This artifact arises from the spins, at a location distant from the magnet isocenter, that are excited and aliased to the field of view because their precession frequency is similar to those at the isocenter. Such a situation is created due to a combination of excessive gradient nonlinearity and rapid change of the main magnetic field near the edge of the magnet where the artifact-producing spins are located.

DC103 Xiaohong Joe Zhou
Method for Simultaneous MR Elastography and Diffusion Acquisitions: Diffusion-MRE (dMRE)

MR elastography (MRE) is an emerging imaging technology that is capable of assessing tissue stiffness through the visualization and analysis of low-frequency mechanical shear waves. In the brain, diffusion-weighted imaging (DWI) is now well established for the clinical assessment of stroke patients, and diffusion tensor imaging (DTI) is very useful for the detection of brain diseases associated with myelin and axonal injuries.. In addition, diffusion MRI has recently been extended to abdominal targets, particularly in the liver.

DH039 Dieter Klatt
Method for Reducing Chemical Shift Displacement Errors in 2D MR Spectroscopy (sLASER-first-COSY)

Magnetic Resonance (MR) spectroscopy is a non-invasive diagnostic test that measures biochemical changes in the brain to differentiate between different neurological conditions and tumor types.

DG127 Shaolin Yang
Method for Selective Spectral Displacement Projection in 3D Multifrequency MRE (SDP-MRE)

Pathological changes involve an alteration of tissue mechanical properties. For example, the increase of connective tissue within the liver during the progression of hepatic fibrosis leads to a stiffening of the organ, while mechanical response of the brain is decreased in neurodegenerative diseases such as multiple sclerosis and Alzheimer’s disease. In Magnetic Resonance Elastography (MRE), external vibrations are introduced into the target tissue, measured via phase-contrast based MRI and analyzed for determining tissue mechanical properties.

DG095 Temel Yasar
A Hypervirulent Mutant of Agrobacterium Tumefaciens

The mutant Agrobacterium tumefaciens has a functionally deleted atu1060 gene that codes for the cyclic di-GMP synthase Atu1060. The mutant exhibits altered polar binding and an increased efficiency for causing crown gall tumors, which may explain the increased efficiency.

This mutation provides a cost effective way to make crops more genetically competitive. It can be used to transform a wider variety of commercially important plants, even plants that are traditionally resistant.

TF09160 Stephen Farrand
A Novel Efficient And Reliable DC/AC Converter For Fuel Cell Power Conditioning

Fuel-cell (FC) energy systems have to address three key issues to achieve their potential: cost, durability and energy efficiency. 

Power electronics, which interfaces directly to the cell array and stacks, has a great impact on the long-term durability energy efficiency of the fuel cells. Fuel cell power-conditioning system energy-conversion efficiency is of significant importance in light of the lower kW/doIlar of some conventional energy systems. Today, the efficiencies of power-electronics conversion technology have exceeded 90%. 

CW074 Sudip Mazumder, Kaustura Acharya, Rajni Burra
Med-Dashboard™ for Patient Management

Currently very few technologies replace the paper and pen  carried by physicians.  Most of these are either web based or they operate only on one platform. 

Inventors at UIC have developed an end-to-end mobile computing patient management system  that will integrate physician sign-out, visualization of patient data, clinical outcomes data collection, order writing, task management and  supervision by attending physicians. 

DF144 Birk, Buy et al.
New 3D Gels for Cell Culture and Therapy

Researchers from the University of Illinois have created a new porus 3D gel. This gel can be prepared with a variety of natural or synthetic polymers and can also contain growth factors or other cellular signaling molecules to improve 3D cell culturing.

This technology has the potential to be used in many novel techniques including stem cell therapy, organ and skin transplants as well as many research technologies and other medical processes.

TF13139 Hyun Joon Kong
Site- and Stereoretentive Cross-Coupling of Unactivated Secondary Boronic Acids

University of Illinois researchers have developed a reaction that allows for the retention of stereochemistry in the Suzuki-Miyaura cross-coupling of boronates

TF13130 Martin Burke
Advanced Technique for Processing Sacrificial Fibers

Researchers from the University of Illinois have developed a new method for making sacrificial fibers. This method can be used to produce larger and more complex microvascular networks in polymers and fiber-reinforced composites. The better mixing method means that the networks left will be more uniform. These microvascular networks are useful for cooling, self-healing applications, or for weight saving designs.

Scott White
String Protection for Photovoltaic Cells

Researchers from the University of Illinois have developed a method and apparatus to protect solar cells from hot spotting and damage resulting from arc faults. This device would also provide a way to shut off the solar array remotely.

By preventing the damage caused by hot spotting and arc faults this device increases the longevity of solar arrays. It also reduces the risk of fire and provides a remote way to cut the power in cases of emergency.

TF13113 Philip Krein
New Way to Detect DNA Changes

Researchers from the University of Illinois have identified a new, cheaper and easier way to detect methylation (alterations) of DNA. By measuring the methylation of certain DNA sequences, doctors can predict the likelihood of cancers and other disorders. This early detection has the potential to save lives.

TF13109 Rashid Bashir
Real-Time 3D Face Modeling with a Commodity Depth Camera (Open Source)

Researchers at the University of Illinois have developed a software for real-time 3D face modeling with a commodity depth camera. This invention captures more facial detail and produces a better output than current techniques using commodity depth cameras.

Find out more about this technology here.


TF13066 Minh Do
Miniaturized Walking Biological Machines

Dr. Bashir has developed a walking biological machine. This "bio-bot" can move spontaneously, and may be useful for sensing, information processing, transport, protein expression and actuation applications.

TF13108 Rashid Bashir
Virtual Oscillator Control of Power Electronic Inverters

Researchers from the University of Illinois have developed a device that will synchronize the output of DC/AC inverters for the purpose of combining them into a micro-grid. The system would instantly react to power supplies suddenly connecting or disconnecting without ever allowing any deviation from the present perameters.

The benefits over current systems is the lack of communication needed, and the impossibility of dangerous surges while adjusting to sudden changes.

TF13105 Philip Krein
New, Improved Contrast Agents for MRI

Researchers at the University of Illinois have identified a new nanoparticle that is easily assembled and yields improved images from MRI scans. The nanoparticle consists of a liposome coated with Gd, solely on the surface which allows for a higher MR signal intensity. These particles also extended the circulation time of Gd in the blood.


TF13104 Hyun Joon Kong
Novel Method for the Production of Nylon

University of Illinois researchers have identified a new process for the production of nylon. Nylon is one of the most commonly used polymers, however the common production technology uses high temperatures & pressures and creates undesirable by-products.

This novel method is performed at room temperature & pressure and only creates water as a by-product. This is an extremely environmentally friendly method and will allow us to continue to enjoy the benefits of stockings, fabrics, ropes and other items we use daily.

TF13103 Jennifer Lewis
High Power Flow Battery

Researchers from the University of Illinois have developed a novel membrane formulation for use in flow batteries or fuel cells. The device, based on synthetic metals (electroconductive polymers) and iron based redox couples, enables a higher rate of energy delivery.

This will enable utility scale energy storage for the next generation electrical grid. Such technology enables lower cost, lowre volume, and higher rates of delivery than current mechanisms.

TF13101 Martin Gruebele
Novel Use for Personal Glucose Meters

University of Illinois researchers have identified a new use for hand-held glucose meters to detect a variety of new disorders. By measuring the concentration of a certain cofactor, the glucose meter can correlate the reading to other non-diabetes diseases.

TF13098 Yi Lu
Complex and Diverse Compounds from Abietic Acid

Dr. Paul Hergenrother from the University of Illinois has created a diverse compound screening library from the synthetic scaffold abietic acid. Abietic acid is an abundant and widely available compound. Through manipulation of the ring system, the Hergenrother lab has constructed more than 91 novel and diverse compounds to be used in a high throughput drug screen.

TF13097 Paul Hergenrother
Blue-Shifting of Resonant Dispersive Wave Pulses

Researchers from the University of Illinois have developed a way to shift a laser beam into a broadband of light with lower wavelengths.

This technology enables the use of pulsed pump lasers in ultrafast spectroscopy, nonlinear biomedical imaging, and many other imaging fields.

TF13086 Stephen Boppart
Quantitative Pneumatic Otoscopy

University of Illinois researchers have developed a device for accurately measuring the rigidity of the ear drum, which is crucial in diagnosing Otis Media and Otis Media with effusion.

Currently the pneumatic otoscopes used rely on the doctor visually diagnosing, and over 50% of the diagnoses are correct.

TF13079 Stephen A. Boppart
Disposable Micro Gas Chromatography Column

Researchers at the University of Illinois have developed a novel method for the fabrication of an all-polymer micro GC column. This method is extremely exciting and the lab has been able to produce columns that have similar separation capabilities as the much more expensive models on the market now.

TF13077 Kenneth S. Suslick
siRNA Delivery System for Inflammatory Diseases

Researchers at the University of Illinois have developed a system for delivering small interfering RNA (siRNA). siRNA can be used as a specific form of interference in the inflammation cascade that could be used to treat inflammatory diseases. The invention greatly enhances the delivery efficiency of the siRNA to the intended tissue.

This technology was developed in the laboratory of Dr. Jianjun Cheng, who has made significant contributions to Drug Delivery. For more about the Cheng Research Group, visit http://cheng.matse.illinois.edu/index.htm


TF13054 Jianjun Cheng
A Novel 3D Microbattery Architecture Created by 3D Printing

Researchers from the University of Illinois and Harvard have developed methods to prepare cathode and anode electrode materials to produce inks for depositing an intericate, interdigitated 3D architecture via 'direct-write' 3D printing method for building a 3D microbattery for small electronics such as medical implants.

TF13064 Shen J. Dillon
Scalable Semiconducting Carbon Nanotube Purification

Researchers fromt the University of Illinois have developed a method of identifying and removing the metallic carbon nanotubes in an array without damaging the semiconducting carbon nanotubes. The method is nearly 100% effective and scalable to large arrays.  This technology enables the large-scale creation of CNT arrays with a very high I on/I off ratios.

TF13051 John Rogers
Multi-Gang Electrical Box for Confined Spaces

Researchers at the University of Illinois have invented a new form of "vertical gang" electrical box which can be used for providng volume for wire connections and splices in applications with confied spaces where the electrical devices are relatively deep.

TF13047 Philip Krein
Less Toxic Amphotericin B Derivative

Researchers at the University of Illinois have d eveloped a derivative of Amphotericin B that likely has a lower toxicity than the popular fungicide. The derivative binds ergosterol but not cholesterol, which retains its fungicidalk properties without the toxicity.

TF13039 Martin Burke
Ultrasensitive Detection of Immunoassays

Researchers at the University of Illinois have developed an ultrasensitive test based on enzymatic enhancement of immunoassays using photonic sensor arrays. This technology offers high gains in sensitivity compared to traditional ELISA tests and thus is suitable for challenging biosensing applications such as serum and cerebrospinal fluid diagnostics.

TF13037 Ryan Bailey
Stabilized Natural Flavorant

Researchers at the University of Illinoi shave developed a method for stabilizing the common natural flavorant 2-Acetyl-1-pyrroline and its homologues. The composition is significantly more stable than 2-AP and can be implemented without major expense.

TF13036 Keith Cadwallader
Transient electronics utilizing conventional foundry processes
Researchers from the University of Illinois have developed a process that is fully compatible with conventional foundry processes for manufacturing transient electronics.
Utilizing conventional foundry processes allows high volume, low cost production of transient electronics which may expedite commercialization of transient technology. 
John Rogers
SLICE Tablet Software Development Framework (Open Source)

Researchers at the University of Illinois have created a software framework for developing pen based apps for Android and Windows tablets. The applications that have been built using this framework are primarily for education apps and connected classrooms as they help facilitate communication among several users.

For more information and to download: http://slice.cs.uiuc.edu

TF13022 Samuel Kamin
Assertion Generation Suite

University of Illinois researchers have developed this suite of assestion generation tools which includes:

A Figure of Merit Evaluation: a method to evaluate and rank assertions used in hardware design validation based on readability and importance

Shobha Vasudevan
Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics
Researchers from the University of Illinois and Washington University  have developed a new design for injectable class of cellular-scale optoelectronics  wit h wireless and programmed control of complex behavior  over freely moving animals in elaborate environmental contexts.
TF13015 John Rogers
Tuneable High Throughput Platform for Studying Protein-Membrane Interactions

Researchers at the University of Illinois have developed a precisely controlled high throughput platform for studying protein-lipid bilayer interactions in a precision manner.  The technique does not require chemical modification or tagging of biomolecules preventing alterations to their native and thus active conformations.

The platform can be used to expedite studies of protein-bilayer interaction mechanisms or drug desing strategies.

Stephen Sligar
Ryan Bailey
Colorimetric Imaging of Biomolecules using nano-Lycurgus Cup Arrays
Researchers from the University of Illinois have developed a new way to use surface plasmon resonance that allows for quantitative analysis using colorimetric techniques.
TF13004 Gang Logan Liu
Expedited Test for Bt resistance in Western Corn Rootworm

Researchers from the University of IL have developed a quick test to test for Bt resistance in Western Corn Rootworm (WCR)  that can be carried out on adult WCRs and takes 10 days compared to 1 year for current testing method.

The test provides real-time resistance and thus is up-to-date with evolving Bt resistance in crops, allowing early & effective counter measures.


TF12203 Manfredo Seufferheld
Stretchable Batteries with Self-Similar Serpentine Interconnects and Integrated Wireless Recharging Systems

Researchers at the University of Illinois  have developed a new design for manufacturing stretchable batteries with "self-similar serpentine interconnects" that offers extraodinary stretchability along with high recharging capacity. 

In addition, their design also includes stretchable inductive coils that allows wireless recharging without any direct physical contact. 

These batteries will be useful for powering wearble and epidermal electronics, a new class of electronic and optoelectronic technology.

TF12197 John Rogers
Improved Quantum Well Transistor Laser

Researchers at the University of Illinois have improved the performance of a Quantum Well Transistor and Laser. Their invention helps improve the performance of optical communications systems and can also be used to determine the noise figure of semiconductor optical amplifiers.

Overview of the Transistor Laser (from the website of Professor Feng):

TF12193 Milton Feng
RNAi-Assisted Genome Engineering

Researchers at the University of Illinois have developed a method for genomic engineering that takes advantage of RNAi. The technology is a platform for improving a yeast strain's properties by using RNAi in an iterative manner to "evolve" the organism. The invention could potentially be used to engineer improved yeast strains for biofeuls, pharmaceutical research, food and beverage processing, and agriculture.

TF12191 Huimin Zhao
Antibacterial Drug Targeting Isoprenoid Biosynthesis

Researchers at the University of Illinois and the University of California at San Diego have developed a variety of potential inhibitors of Isoprenoid biosynthesis, an integral step in bacterial cell wall synthesis. The inhibitors may be useful in killing other strains that have developed resistance to other anti-bacterials.

TF12190 Eric Oldfield
Coupled Heterogeneous Nanowire Nanoplate Planar Transistor Sensors for Giant Nernst Response

Researchers at the University of Illinoi sand Purdue University have designed new Ion-Sensitive Field Effect Transistors (ISFETs) for monitoring the pH of electrolytes with >10 V/pH Nernst response with a top-down CMOS compatible approach. This technology may be useful for biomedical applications like prton-based genome sequencers, pharmaceutical testing, and environmental toxin monitoring.

TF12185 Rashid Bashir
Continuous Flow Anti-solvent Crystallization

Researchers from the University of Illinoi shave developed a composition for crystallizing Active Pharmaceutical Ingredients (API). This invention allows for a smaller distribution of particle size. It could potentially enable particle synthesis suitable for inhalable pharmaceuticals.

TF12177 Kenneth Suslick
Dispersion-Relation Fluorescence Spectroscopy

Researchers from the University of Illinois have developed a new  method of studying live cell dynamics and function - particularly molecular transport dynamics - over a broad range of spatial and temporal scales.

The method uses fluorescence rather than inserting probes. It can distinguish between diffusive motion and advection motion as well as diffusive transport and active or directed transport.

TF12170 Gabriel Popescu
Graphics & Tools from the NCSA's Advanced Visualization Laboratory

From the Advanced Visualization Laboratroy's website...

The Advanced Visualization Laboratory (AVL) creates high-fidelity, data-driven scientific visualizations in 3D.

Electronic Tuning of Site Selectivity for Complex Molecule Synthesis

Researchers from the University of Illinois have developed a method for selectively derivatizing complex natural molecules such as Amphotericin B. The technology could allow for greater regio-control over current synthetic methods.

TF12157 Martin Burke
Smartphone Biosensor

Researchers at the University of Illinois have developed a portable spectrometer cradle that can be attached to smartphones.

The device uses the camera lens and light source of the smartphone to enable the spectrometer assembly in the cradle and measure the intensity and wavelength of the light similar to a lab spectrometer. The spectrometer cradle could instead incorporate its own low powered laser within the cradle as well.

TF12154 Brian Cunningham
Extreme Miniaturized 3D Spiral On-Chip Inductors, Transformers, and Transmission Lines


Researchers at the University of Illinois have developed a novel design of on-chip inductors using multiple turn microtubes based on stain-induced self-rolled-up nanotechnology.

This technology would allow nearly 200x smaller footprint  compared to conventional planar inductors while achieving significant performance improvements in all aspects.

Xiuling Li
Four Level Laser Pumping Method

Researchers at the University of Illinois have developed a new laser pumping method which provides efficient and continuous high power (>10W) lasers in the visible, ultraviolet, and near-infrared regions in both gas and solid state systems.

This method allows cooling of the laser medium while achieving over 100% quantum efficiency. Combined with frequency doubling this laser should yield more than 10 watts of violet (426 or 427 nm), a region of the spectrum in which no powerful sources exist.

TF12143 James Gary Eden
Computed Pathology: Stain-Free Computational Imaging

Researchers fromt he University of Illinoi shave developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological samples without the use of any stains or dyes. The tissue is computationally recreated as if it were stained and imaged in diagnosis of biological samples.

This method improves the cost and efficiency by avoiding expense and lessening the time required to complete multiple stains. Also, it improves the overall consistency of the staining process.

TF12133 Rohit Bhargava
Coherently Scattering Probes for Super-resolved Mapping

Researchers at the University of Illinois have developed coherently scattering probes to allow imaging of intracellular structures at nanometer spatial resolution using far-field instruments. The probes can acquire data in a multiplex fashion,

This technology circumvents the temporal multiplexing of conventional PALM/STORM microscopy. Images are acquired quickly with high signal-to-noise ratio, making it applicable for dynamic biological samples.

TF12132 P. Scott Carney
High Efficiency Photocatalytic Systems

Researchers from the University of Illinois have developed a high efficiency photocatalytic system using novel oxide materials that allow absorption of a broader range of the solar spectrum than existing photocatalysts.

The ability to absorb more solar radiation increases the efficiences of the photocatalytic system by 3-4x existing systems.

The invention is envisioned to improve processes for splitting water to produce hydrogen as well as conversion of CO2 to simple and higher order fuels.

TF12124 Lane Martin
Transfer Printing of Flexible High-Quality Functional Insulators

Researchers from the University of Illinois have developed a new transfer printing method that facilitates flexible electronics devices with high-quality functional insulators in the structure.

By utilizing pre-etched silicon-on-insulator (SOI) wafers, the deposited high-quality insulator is free from fluorine-based wet etching, thereby maintaining insulator quality and preventing device degradation.

TF12116 Kyekyoon Kim
Optical Parametric Amplification of Weak Signals for Imaging Biological Tissue

Researchers at the University of Illinois have developed a method of applying optical parametric amplification technology to enhance ultrweak signals from scattering biological tissue. This method can also  be utilized for other types of signals such as fluorescence, parametirc processes, and Raman for tissue analysis in research applications.

Although high sensitivity photodetectors exist, this method deals with instances of extremely low-level light signals that w ould otherwise result in long integration time and slow imaging speed.

TF12107 Stephen Boppart
TIGER: Tiled Iterative Genome Assembler

A University of Illinois team has identified a new and efficient method for genome assembly.  The iterative algorithm has the ability to embed multiple assemblers in it and produce an assembled genome at a fraction of the cost and using significantly fewer resources than traditional assemblers.

TF12074 Wen-Mei Hwu
Parallel Interleaved Inverters for Efficient DC-AC Power Conversion and Low Distortion Current Output

Researchers from the University of Illinois have developed a new method to reduce the distortion in the output c urrent of multiple inverters used in DC to AC power conversion. This new technology helps to reduce the size and cost of the power electronic components currently used in power conversion. Also, this method is scalable and so this concept can be implemented on micro-scale systems. 

TF12063 Philip T Krein
High Performance, Energy Efficient Chipkill Correct Memory w ith Multidimensional Parity

Researchers at the University of Illinois have developed a new error correction code to reduce the power consumption in the memory systems of data servers.  By sharing the resources available for error correction, this software reduces the power of chipkill correct memories (a type of error correction in memory in case of chip failure) in DRAM chips.  This is accomplished without c ompromising the reliability against soft errors.

TF12060 Rakesh Kumar
Nitrated sphingosine 1-phosphate 3 receptor (S1P3R) in endothelial microparticles is a novel biomarker in acute lung injury and predictor of ALI-associated mortality

Research done under Dr. Joe Garcia, from UIC’s Dept. of Medicine, has detected significantly elevated levels of nitrated S1PR3 in the blood plasma of ALI patients, and has correlated high levels of S1PR3 with high mortality rates in these patients. The investigators have discovered a novel biomarker that should allow for easy, rapid diagnosis and evaluation of patients with ALI via blood sample. 

DF022 Joe G. Garcia
A Bio-chemical Nano Reactor Based on Membrane Liquid Cells


Cryo transmission electron microscopy has been extensively used in modern biological research to study cells and other tissue samples. The addition of these electron microscopy (EM) accessories to EMs can further the study of biological samples and chemical reactions. 

Canhui Wang
Robert F. Klie
Tolou Shokuhfar
Method and software to analyze muscle cell function

In vitro experiments on muscle cells are limited by the fact that there is no method for analyzing the improvement or decline in function of the muscle cells. There is also a need for software which can analyze data should there be a method to analyze muscle function over time. Researchers have in the past decided when to test by a manual and random technique. This does not allow the researcher to fully analyze the form and function of the cells.

Kathleen Broughton
Matthew Curtis
Brenda Russel
Luciferin-based biosensors to specifically detect peroxynitrite or hydrogen peroxide in vivo or in vitro

Hydrogen peroxide (H2O2) is a compound which is produced by living organisms to kill invading pathogens and for cellular signaling. Abnormal production of H2O2 results from oxidative stress related from aging, disease and injury. The study of H2O2 in relation to health of animals has been limited by a lack of methods to study H2O2 in the context of animal health and because of the transient nature of this molecule.

DF082 Marcelo Bonini, Ph.D.
Ex vivo expanded blood progenitor cells for faster reconstitution and sustained blood cell production Hematopoietic stem cells (HSC) transplantation, in some instances following high-dose chemotherapy or radiation therapy, offers the best treatment option for most leukemias and other malignant and non-malignant blood disorders. A HSC transplant can help the body make enough healthy white blood cells, red blood cells or platelets to replace damaged or diseased cells, and reduce the risk of life-threatening infections, anemia and bleeding.However, the difficulty of obtaining tissue matched donors limits the widespread use of allogeneic HSC transplantation to treat these diseases. DF072
Nadim Mahmud, MD, PhD
Hiroto Araki
A specific chemokine dampens inflammatory heart disease

Heart disease is the leading cause of death, disability, and healthcare expenditure in the U.S. and is the leading cause of death worldwide.  New treatments for heart disease could affect a broad population and have significant health and financial benefits.  Inflammatory heart disease (IHD) is inflammation of heart muscles caused a bacteria or virus infection or from an internal peculiarity.  IHD is often associated with episodes of rheumatic fever and kawasaki disease and may be classified as either myocarditis, pericarditis or endocarditis.

DF119 Kurt Bachmaier, MD, Ph.D.
Novel Selective Estrogen Mimics for Extending Survival Times of Tamoxifen-Resistant Breast Cancer Patients

Approximately 230,000 new cases of breast cancer (BC) appear in the US each year making BC the most common type of cancer in women and the second deadliest type of cancer in the United States. Up to 80% of BC’s are estrogen receptor positive (ER+) in which estrogen promotes tumor growth and patients with hormone receptor-positive metastatic breast cancer (MBC) typically undergo endocrine therapy as the initial therapeutic option.

Gregory Thatcher, Ph.D.
Debra Tonetti, Ph.D.
Mouse monoclonal antibody for human lipid phosphate phosphatase-3 (LPP3) DF025 Kishore Wary, Ph.D.
Small molecules that inhibit intercellular communication of Gram-positive bacteria

Small molecule inhibitors of peptide mediated intercellular signaling among gram positive bacteria such as Streptococcus pyogenes are responsible for a wide array of negative effects in infections, such as biofilm formation, virulence, and incorporating foreign DNA with potential to acquire antibacterial resistance.  

Michael Federle, Ph.D.
George Chlipala, Ph.D.
Data acquisition and analysis software for laser desorption, imaging mass spectrometers

The software for the laser desorption/ablation time-of-flight mass spectrometer is for imaging applications and is designed for two different time-of-flight (TOF) mass spectrometers.  The software can be used for any mass spectrometer instruments that use motor controllers from PI miCos Gmbh or Newport Corp. or Gage Applied digitizer cards.

Luke Hanley
Yang Cui
NAPRALERT, the trademarked acronym for Natural Products Alert, an extensive online database for medicinal natural product information

The NAPRALERT® is the world’s first computerized database of ethnobotany, pharmacology, chemistry, toxicology, and clinical trials on medicinal plants. NAPERALERT was created in 1975 by the late Norman R. Farnsworth, Ph.D. More than 200,000 scientific reviews and articles are on NAPRALERT and contain information on natural products and the organisms which produce the products.

Norman R. Farnsworth Ph.D.
Polycistronic co-expression and nondenaturing purification of histone octamers

Histone octamers are the basic building blocks of chromatin and are platforms for diverse genetic mechanisms. In nucleosomes they set the stage for genetic transactions such as replication, transcription, and repair, and they are often the direct targets of protein machineries controlling these processes. Compositional and post-translational variations in histones also sculpt the epigenetic landscape for gene regulation.

DG075 Jung-Hyun Min, Ph.D.
Secondary metabolite fractionated libraries from crude extracts of marine-derived Actinomycete bacteria

The surfaces of marine organisms provide a source of nutrients for microbes within our oceans. Consequently a competition for space results between surface-colonizing (epibiotic) microorganisms.

Select secondary metabolites from epibiotic bacteria, which serve as chemical defenses or means of inter- and intra-species microbial communication, can be utilized to probe and combat the pathogenic mechanisms of human microbial pathogens.

DF016 Brian Murphy, Ph.D.
Novel Isoxazole, Urea, and Indole Based HDAC6 Selective Inhibitors for the Treatment of Charcott-Marie-Tooth (CMT), Neurodegenerative diseases, Pancreatic Cancer, as well as Immune diseases; a new epigenetic approach to therapy

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome.

Alan P. Kozikowski, Ph.D.
Microfluidic Device Platform for Perfusion Chamber Systems

In stroke research, the hippocampal acute brain slice preparation is a model for studying how neuronal tissue responds to a hypoxic insult. Additionally, in diabetes research, pancreatic islets preparation and dynamic loading of oxygen and glucose is critical to understand how hypoxia alters the glucose-insulin response of the pancreas. However, standard techniques using commercial perfusion chambers cannot accurately provide oxygen delivery and control to model hypoxic conditions.

David Eddington, PhD
Nexturastat, a novel Urea-based HDAC6 inhibitor effective against specific cancers

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.

Alan P. Kozikowski, Ph.D.
Joel Bergman, Ph.D.
Novel Isoxazole-Based HDAC6 Selective Inhibitors for the Treatment of Charcott-Marie-Tooth (CMT), a new epigenetic approach to therapy

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 

Alan P. Kozikowski, Ph.D.
Irina Gaisina, Ph.D.
Carbazole Derivatives as G9a Methyltransferase Inhibitors for Cancer Treatment and Autophagy Induction.

G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation.

DF108 Alan P Kozikowski, Ph.D.
CAVE2 (TM) System

Increasingly, the Nation’s computational science and engineering research communities work with international collaborators to tackle complex global problems.

Andrew Johnson, PhD
Maxine Brown, PhD
Jason Leigh, PhD
Thomas Perterka, PhD
Daniel Sandin, PhD
Scalable Peer-to-Peer Streaming Protocol for Real Time Data

Current direct real time streaming implementations on the internet are limited by bandwidth consumption.  Peer-to-Peer streaming reduces server bandwidth requirements, but it is vulnerable to delay and reliability issues that multiply as the network scales in size.  Current Peer-to-Peer streaming implementations do not scale well and are not robust 

This scalable Peer-to-Peer protocol uses an elegant network formation and maintenance algorithm that minimizes the issues of peer churn, bum peers, and delay, providing for maximum theoretical scaling.


TF11142 Srikant Rayadurgam
Mouse model for mutant allele of the cell cycling inhibitor BARA in mice.