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Search Technologies

The research and level of innovation at the University has resulted in an impressive and balanced portfolio of technologies including everything from therapeutic treatments to new crop varieties, semiconductors to genetic algorithms, imaging agents to internet tools, and fuel cells to microfluidics.

Title Teaser Technology Numbers Inventor Name
Mouse Retinal Photoreceptor-Derived Cell Line (661 W)

The mouse retinal photoreceptor-derived 661W cell line was developed by researchers at the University of Oklahoma Health Sciences Center and the University of Illinois to study cone photoreceptor cell function and to understand diseases affecting cone photoreceptor cells.

OU Technology 05HSC006
DC076
Muayyad Al-Ubaidi
Development of low-glutaminase Erwinia chrysanthemi L-asparaginase: Novel Engineered enzymes with lower side effect profile

UIC-2015-021

Arnon LaVie
Synthetic Ebola glycoprotein for screening anti-Ebola virus entry inhibitors

UIC-2015-047

Lijun Rong
A new glioma cKO LKB1 (conditional knock-out Liver Kinase B1) cell line for cancer research

TF13064 Shen J. Dillon
Scalable Semiconducting Carbon Nanotube Purification

Researchers fromt the University of Illinois have developed a method of identifying and removing the metallic carbon nanotubes in an array without damaging the semiconducting carbon nanotubes. The method is nearly 100% effective and scalable to large arrays.  This technology enables the large-scale creation of CNT arrays with a very high I on/I off ratios.

TF13051 John Rogers
Multi-Gang Electrical Box for Confined Spaces

Researchers at the University of Illinois have invented a new form of "vertical gang" electrical box which can be used for providng volume for wire connections and splices in applications with confied spaces where the electrical devices are relatively deep.

TF13047 Philip Krein
Less Toxic Amphotericin B Derivative

Researchers at the University of Illinois have d eveloped a derivative of Amphotericin B that likely has a lower toxicity than the popular fungicide. The derivative binds ergosterol but not cholesterol, which retains its fungicidalk properties without the toxicity.

TF13039 Martin Burke
Ultrasensitive Detection of Immunoassays

Researchers at the University of Illinois have developed an ultrasensitive test based on enzymatic enhancement of immunoassays using photonic sensor arrays. This technology offers high gains in sensitivity compared to traditional ELISA tests and thus is suitable for challenging biosensing applications such as serum and cerebrospinal fluid diagnostics.

TF13037 Ryan Bailey
Stabilized Natural Flavorant

Researchers at the University of Illinoi shave developed a method for stabilizing the common natural flavorant 2-Acetyl-1-pyrroline and its homologues. The composition is significantly more stable than 2-AP and can be implemented without major expense.

TF13036 Keith Cadwallader
Transient electronics utilizing conventional foundry processes
Researchers from the University of Illinois have developed a process that is fully compatible with conventional foundry processes for manufacturing transient electronics.
 
Utilizing conventional foundry processes allows high volume, low cost production of transient electronics which may expedite commercialization of transient technology. 
 
TF13035
John Rogers
SLICE Tablet Software Development Framework (Open Source)

Researchers at the University of Illinois have created a software framework for developing pen based apps for Android and Windows tablets. The applications that have been built using this framework are primarily for education apps and connected classrooms as they help facilitate communication among several users.

For more information and to download: http://slice.cs.uiuc.edu

TF13022 Samuel Kamin
Assertion Generation Suite

University of Illinois researchers have developed this suite of assestion generation tools which includes:

A Figure of Merit Evaluation: a method to evaluate and rank assertions used in hardware design validation based on readability and importance

TF13018
TF13019
TF13020
Shobha Vasudevan
Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics
Researchers from the University of Illinois and Washington University  have developed a new design for injectable class of cellular-scale optoelectronics  wit h wireless and programmed control of complex behavior  over freely moving animals in elaborate environmental contexts.
TF13015 John Rogers
Tuneable High Throughput Platform for Studying Protein-Membrane Interactions

Researchers at the University of Illinois have developed a precisely controlled high throughput platform for studying protein-lipid bilayer interactions in a precision manner.  The technique does not require chemical modification or tagging of biomolecules preventing alterations to their native and thus active conformations.

The platform can be used to expedite studies of protein-bilayer interaction mechanisms or drug desing strategies.

TF13014
Stephen Sligar
Ryan Bailey
Colorimetric Imaging of Biomolecules using nano-Lycurgus Cup Arrays
Researchers from the University of Illinois have developed a new way to use surface plasmon resonance that allows for quantitative analysis using colorimetric techniques.
TF13004 Gang Logan Liu
Expedited Test for Bt resistance in Western Corn Rootworm

Researchers from the University of IL have developed a quick test to test for Bt resistance in Western Corn Rootworm (WCR)  that can be carried out on adult WCRs and takes 10 days compared to 1 year for current testing method.

The test provides real-time resistance and thus is up-to-date with evolving Bt resistance in crops, allowing early & effective counter measures.

 

TF12203 Manfredo Seufferheld
Stretchable Batteries with Self-Similar Serpentine Interconnects and Integrated Wireless Recharging Systems

Researchers at the University of Illinois  have developed a new design for manufacturing stretchable batteries with "self-similar serpentine interconnects" that offers extraodinary stretchability along with high recharging capacity. 

In addition, their design also includes stretchable inductive coils that allows wireless recharging without any direct physical contact. 

These batteries will be useful for powering wearble and epidermal electronics, a new class of electronic and optoelectronic technology.

TF12197 John Rogers
Improved Quantum Well Transistor Laser

Researchers at the University of Illinois have improved the performance of a Quantum Well Transistor and Laser. Their invention helps improve the performance of optical communications systems and can also be used to determine the noise figure of semiconductor optical amplifiers.

Overview of the Transistor Laser (from the website of Professor Feng):

TF12193 Milton Feng
RNAi-Assisted Genome Engineering

Researchers at the University of Illinois have developed a method for genomic engineering that takes advantage of RNAi. The technology is a platform for improving a yeast strain's properties by using RNAi in an iterative manner to "evolve" the organism. The invention could potentially be used to engineer improved yeast strains for biofeuls, pharmaceutical research, food and beverage processing, and agriculture.

TF12191 Huimin Zhao
Antibacterial Drug Targeting Isoprenoid Biosynthesis

Researchers at the University of Illinois and the University of California at San Diego have developed a variety of potential inhibitors of Isoprenoid biosynthesis, an integral step in bacterial cell wall synthesis. The inhibitors may be useful in killing other strains that have developed resistance to other anti-bacterials.

TF12190 Eric Oldfield
Coupled Heterogeneous Nanowire Nanoplate Planar Transistor Sensors for Giant Nernst Response

Researchers at the University of Illinoi sand Purdue University have designed new Ion-Sensitive Field Effect Transistors (ISFETs) for monitoring the pH of electrolytes with >10 V/pH Nernst response with a top-down CMOS compatible approach. This technology may be useful for biomedical applications like prton-based genome sequencers, pharmaceutical testing, and environmental toxin monitoring.

TF12185 Rashid Bashir
Continuous Flow Anti-solvent Crystallization

Researchers from the University of Illinoi shave developed a composition for crystallizing Active Pharmaceutical Ingredients (API). This invention allows for a smaller distribution of particle size. It could potentially enable particle synthesis suitable for inhalable pharmaceuticals.

TF12177 Kenneth Suslick
Dispersion-Relation Fluorescence Spectroscopy

Researchers from the University of Illinois have developed a new  method of studying live cell dynamics and function - particularly molecular transport dynamics - over a broad range of spatial and temporal scales.

The method uses fluorescence rather than inserting probes. It can distinguish between diffusive motion and advection motion as well as diffusive transport and active or directed transport.

TF12170 Gabriel Popescu
Graphics & Tools from the NCSA's Advanced Visualization Laboratory

From the Advanced Visualization Laboratroy's website...

The Advanced Visualization Laboratory (AVL) creates high-fidelity, data-driven scientific visualizations in 3D.

TF12169
TF12207
Electronic Tuning of Site Selectivity for Complex Molecule Synthesis

Researchers from the University of Illinois have developed a method for selectively derivatizing complex natural molecules such as Amphotericin B. The technology could allow for greater regio-control over current synthetic methods.

TF12157 Martin Burke
Smartphone Biosensor

Researchers at the University of Illinois have developed a portable spectrometer cradle that can be attached to smartphones.

The device uses the camera lens and light source of the smartphone to enable the spectrometer assembly in the cradle and measure the intensity and wavelength of the light similar to a lab spectrometer. The spectrometer cradle could instead incorporate its own low powered laser within the cradle as well.

TF12154 Brian Cunningham
Extreme Miniaturized 3D Spiral On-Chip Inductors, Transformers, and Transmission Lines

Inductors

Researchers at the University of Illinois have developed a novel design of on-chip inductors using multiple turn microtubes based on stain-induced self-rolled-up nanotechnology.

This technology would allow nearly 200x smaller footprint  compared to conventional planar inductors while achieving significant performance improvements in all aspects.

TF12147
TF13001
TF13016
Xiuling Li
Four Level Laser Pumping Method

Researchers at the University of Illinois have developed a new laser pumping method which provides efficient and continuous high power (>10W) lasers in the visible, ultraviolet, and near-infrared regions in both gas and solid state systems.

This method allows cooling of the laser medium while achieving over 100% quantum efficiency. Combined with frequency doubling this laser should yield more than 10 watts of violet (426 or 427 nm), a region of the spectrum in which no powerful sources exist.

TF12143 James Gary Eden
Computed Pathology: Stain-Free Computational Imaging

Researchers fromt he University of Illinoi shave developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological samples without the use of any stains or dyes. The tissue is computationally recreated as if it were stained and imaged in diagnosis of biological samples.

This method improves the cost and efficiency by avoiding expense and lessening the time required to complete multiple stains. Also, it improves the overall consistency of the staining process.

TF12133 Rohit Bhargava
Coherently Scattering Probes for Super-resolved Mapping

Researchers at the University of Illinois have developed coherently scattering probes to allow imaging of intracellular structures at nanometer spatial resolution using far-field instruments. The probes can acquire data in a multiplex fashion,

This technology circumvents the temporal multiplexing of conventional PALM/STORM microscopy. Images are acquired quickly with high signal-to-noise ratio, making it applicable for dynamic biological samples.

TF12132 P. Scott Carney
High Efficiency Photocatalytic Systems

Researchers from the University of Illinois have developed a high efficiency photocatalytic system using novel oxide materials that allow absorption of a broader range of the solar spectrum than existing photocatalysts.

The ability to absorb more solar radiation increases the efficiences of the photocatalytic system by 3-4x existing systems.

The invention is envisioned to improve processes for splitting water to produce hydrogen as well as conversion of CO2 to simple and higher order fuels.

TF12124 Lane Martin
Transfer Printing of Flexible High-Quality Functional Insulators

Researchers from the University of Illinois have developed a new transfer printing method that facilitates flexible electronics devices with high-quality functional insulators in the structure.

By utilizing pre-etched silicon-on-insulator (SOI) wafers, the deposited high-quality insulator is free from fluorine-based wet etching, thereby maintaining insulator quality and preventing device degradation.

TF12116 Kyekyoon Kim
Optical Parametric Amplification of Weak Signals for Imaging Biological Tissue

Researchers at the University of Illinois have developed a method of applying optical parametric amplification technology to enhance ultrweak signals from scattering biological tissue. This method can also  be utilized for other types of signals such as fluorescence, parametirc processes, and Raman for tissue analysis in research applications.

Although high sensitivity photodetectors exist, this method deals with instances of extremely low-level light signals that w ould otherwise result in long integration time and slow imaging speed.

TF12107 Stephen Boppart
TIGER: Tiled Iterative Genome Assembler

A University of Illinois team has identified a new and efficient method for genome assembly.  The iterative algorithm has the ability to embed multiple assemblers in it and produce an assembled genome at a fraction of the cost and using significantly fewer resources than traditional assemblers.

TF12074 Wen-Mei Hwu
Parallel Interleaved Inverters for Efficient DC-AC Power Conversion and Low Distortion Current Output

Researchers from the University of Illinois have developed a new method to reduce the distortion in the output c urrent of multiple inverters used in DC to AC power conversion. This new technology helps to reduce the size and cost of the power electronic components currently used in power conversion. Also, this method is scalable and so this concept can be implemented on micro-scale systems. 

TF12063 Philip T Krein
High Performance, Energy Efficient Chipkill Correct Memory w ith Multidimensional Parity

Researchers at the University of Illinois have developed a new error correction code to reduce the power consumption in the memory systems of data servers.  By sharing the resources available for error correction, this software reduces the power of chipkill correct memories (a type of error correction in memory in case of chip failure) in DRAM chips.  This is accomplished without c ompromising the reliability against soft errors.

TF12060 Rakesh Kumar
A Bio-chemical Nano Reactor Based on Membrane Liquid Cells

 

Cryo transmission electron microscopy has been extensively used in modern biological research to study cells and other tissue samples. The addition of these electron microscopy (EM) accessories to EMs can further the study of biological samples and chemical reactions. 

DG128
Canhui Wang
Robert F. Klie
Tolou Shokuhfar
Method and software to analyze muscle cell function

In vitro experiments on muscle cells are limited by the fact that there is no method for analyzing the improvement or decline in function of the muscle cells. There is also a need for software which can analyze data should there be a method to analyze muscle function over time. Researchers have in the past decided when to test by a manual and random technique. This does not allow the researcher to fully analyze the form and function of the cells.

DG089
Kathleen Broughton
Matthew Curtis
Brenda Russel
Luciferin-based biosensors to specifically detect peroxynitrite or hydrogen peroxide in vivo or in vitro

Hydrogen peroxide (H2O2) is a compound which is produced by living organisms to kill invading pathogens and for cellular signaling. Abnormal production of H2O2 results from oxidative stress related from aging, disease and injury. The study of H2O2 in relation to health of animals has been limited by a lack of methods to study H2O2 in the context of animal health and because of the transient nature of this molecule.

DF082 Marcelo Bonini, Ph.D.
Ex vivo expanded blood progenitor cells for faster reconstitution and sustained blood cell production Hematopoietic stem cells (HSC) transplantation, in some instances following high-dose chemotherapy or radiation therapy, offers the best treatment option for most leukemias and other malignant and non-malignant blood disorders. A HSC transplant can help the body make enough healthy white blood cells, red blood cells or platelets to replace damaged or diseased cells, and reduce the risk of life-threatening infections, anemia and bleeding.However, the difficulty of obtaining tissue matched donors limits the widespread use of allogeneic HSC transplantation to treat these diseases. DF072
Nadim Mahmud, MD, PhD
Hiroto Araki
A specific chemokine dampens inflammatory heart disease

Heart disease is the leading cause of death, disability, and healthcare expenditure in the U.S. and is the leading cause of death worldwide.  New treatments for heart disease could affect a broad population and have significant health and financial benefits.  Inflammatory heart disease (IHD) is inflammation of heart muscles caused a bacteria or virus infection or from an internal peculiarity.  IHD is often associated with episodes of rheumatic fever and kawasaki disease and may be classified as either myocarditis, pericarditis or endocarditis.

DF119 Kurt Bachmaier, MD, Ph.D.
Novel Selective Estrogen Mimics for Extending Survival Times of Tamoxifen-Resistant Breast Cancer Patients

Approximately 230,000 new cases of breast cancer (BC) appear in the US each year making BC the most common type of cancer in women and the second deadliest type of cancer in the United States. Up to 80% of BC’s are estrogen receptor positive (ER+) in which estrogen promotes tumor growth and patients with hormone receptor-positive metastatic breast cancer (MBC) typically undergo endocrine therapy as the initial therapeutic option.

DG042
Gregory Thatcher, Ph.D.
Debra Tonetti, Ph.D.
Mouse monoclonal antibody for human lipid phosphate phosphatase-3 (LPP3) DF025 Kishore Wary, Ph.D.
Small molecules that inhibit intercellular communication of Gram-positive bacteria

Small molecule inhibitors of peptide mediated intercellular signaling among gram positive bacteria such as Streptococcus pyogenes are responsible for a wide array of negative effects in infections, such as biofilm formation, virulence, and incorporating foreign DNA with potential to acquire antibacterial resistance.  

DG096
Michael Federle, Ph.D.
George Chlipala, Ph.D.
Data acquisition and analysis software for laser desorption, imaging mass spectrometers

The software for the laser desorption/ablation time-of-flight mass spectrometer is for imaging applications and is designed for two different time-of-flight (TOF) mass spectrometers.  The software can be used for any mass spectrometer instruments that use motor controllers from PI miCos Gmbh or Newport Corp. or Gage Applied digitizer cards.

DG023
Luke Hanley
Yang Cui
NAPRALERT, the trademarked acronym for Natural Products Alert, an extensive online database for medicinal natural product information

The NAPRALERT® is the world’s first computerized database of ethnobotany, pharmacology, chemistry, toxicology, and clinical trials on medicinal plants. NAPERALERT was created in 1975 by the late Norman R. Farnsworth, Ph.D. More than 200,000 scientific reviews and articles are on NAPRALERT and contain information on natural products and the organisms which produce the products.

CK03
DF051
Norman R. Farnsworth Ph.D.
Polycistronic co-expression and nondenaturing purification of histone octamers

Histone octamers are the basic building blocks of chromatin and are platforms for diverse genetic mechanisms. In nucleosomes they set the stage for genetic transactions such as replication, transcription, and repair, and they are often the direct targets of protein machineries controlling these processes. Compositional and post-translational variations in histones also sculpt the epigenetic landscape for gene regulation.

DG075 Jung-Hyun Min, Ph.D.
Secondary metabolite fractionated libraries from crude extracts of marine-derived Actinomycete bacteria

The surfaces of marine organisms provide a source of nutrients for microbes within our oceans. Consequently a competition for space results between surface-colonizing (epibiotic) microorganisms.

Select secondary metabolites from epibiotic bacteria, which serve as chemical defenses or means of inter- and intra-species microbial communication, can be utilized to probe and combat the pathogenic mechanisms of human microbial pathogens.

DF016 Brian Murphy, Ph.D.
Novel Isoxazole, Urea, and Indole Based HDAC6 Selective Inhibitors for the Treatment of Charcott-Marie-Tooth (CMT), Neurodegenerative diseases, Pancreatic Cancer, as well as Immune diseases; a new epigenetic approach to therapy

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome.

DC101
DF074
DF132
Alan P. Kozikowski, Ph.D.
Microfluidic Device Platform for Perfusion Chamber Systems

In stroke research, the hippocampal acute brain slice preparation is a model for studying how neuronal tissue responds to a hypoxic insult. Additionally, in diabetes research, pancreatic islets preparation and dynamic loading of oxygen and glucose is critical to understand how hypoxia alters the glucose-insulin response of the pancreas. However, standard techniques using commercial perfusion chambers cannot accurately provide oxygen delivery and control to model hypoxic conditions.

DA077
DF124
David Eddington, PhD
Nexturastat, a novel Urea-based HDAC6 inhibitor effective against specific cancers

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.

DF132
Alan P. Kozikowski, Ph.D.
Joel Bergman, Ph.D.
Novel Isoxazole-Based HDAC6 Selective Inhibitors for the Treatment of Charcott-Marie-Tooth (CMT), a new epigenetic approach to therapy

Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 

DF074
Alan P. Kozikowski, Ph.D.
Irina Gaisina, Ph.D.
CAVE2 (TM) System

Increasingly, the Nation’s computational science and engineering research communities work with international collaborators to tackle complex global problems.

DE079
Andrew Johnson, PhD
Maxine Brown, PhD
Jason Leigh, PhD
Thomas Perterka, PhD
Daniel Sandin, PhD
Scalable Peer-to-Peer Streaming Protocol for Real Time Data

Current direct real time streaming implementations on the internet are limited by bandwidth consumption.  Peer-to-Peer streaming reduces server bandwidth requirements, but it is vulnerable to delay and reliability issues that multiply as the network scales in size.  Current Peer-to-Peer streaming implementations do not scale well and are not robust 

This scalable Peer-to-Peer protocol uses an elegant network formation and maintenance algorithm that minimizes the issues of peer churn, bum peers, and delay, providing for maximum theoretical scaling.

 

TF11142 Srikant Rayadurgam
Mouse model for mutant allele of the cell cycling inhibitor BARA in mice.