Technologies

Renal

Glucagon-like peptide-1 (GLP-1) is a 30-mer peptide hormone secreted by intestinal L-cells that bind to GLP-1 receptor on the β-cell and stimulates insulin secretion in response to ingested carbohydrates and lipids. Native GLP-1 peptide, however, has limited applications as a therapeutic agent due to its rapid elimination in vivo. A number of GLP-1 analogs with longer half-lives have been synthesized and approved for treatment. The aqueous solubility of the peptide is low.
print