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Miniaturized Walking Biological Machines Dr. Bashir has developed a walking biological machine. This "bio-bot" can move spontaneously, and may be useful for sensing, information processing, transport,... Read More Dr. Bashir has developed a walking biological machine. This "bio-bot" can move spontaneously, and may be useful for sensing, information processing, transport, protein expression and actuation applications.
New Way to Detect DNA Changes Researchers from the University of Illinois have identified a new, cheaper and easier way to detect methylation (alterations) of DNA. By measuring the methylation... Read More Researchers from the University of Illinois have identified a new, cheaper and easier way to detect methylation (alterations) of DNA. By measuring the methylation of certain DNA sequences, doctors can predict the likelihood of cancers and other disorders. This early detection has the potential to save lives.
Temperature Independent pH (TIP) Buffers for Use at Low Temperatures Researchers and practitioners in university, industrial and national labs increasingly rely on low temperatures in the development and study of products. For... Read More Researchers and practitioners in university, industrial and national labs increasingly rely on low temperatures in the development and study of products. For example, pharmaceutical companies routinely use low temperatures to study disease targets and markers. The biomolecules are always in buffers. Since the pH of buffers changes dramatically upon lowering temperature, the biolmolecules are not the same pH when they are at the room temperature. The change of pH can dramatically change the structural and functional properties of the biomolecules so that information obtained at low temperature does not reflect its properties at room temperature or physiological temperature. Additionally, since the exact pH buffer at different temperatures is not often predictable, the results obtained using a temperature variable pH buffer cannot easily correlate back to the pH at room temperature. This invention is a new design of pH buffers that show negligible pH change upon cooling to low temperatures, including cryotempatures. This invention solves the problem of significant change in apparent pH of a glycerol solution of common biological buffers upon cooling to cryotemperature. By combining a buffer that increases pH upon cooling with one that decreases pH upon cooling, the apparent pH change upon cooling to cryotemperature is minimized.
Enhanced Resolution for Biomedical Ultrasound Imaging Prof. Oelze from the University of Illinois has developed a novel technique of processing ultrasound images which will improve the spatial resolution by a factor... Read More Prof. Oelze from the University of Illinois has developed a novel technique of processing ultrasound images which will improve the spatial resolution by a factor of 6.9 (at least) over the diffraction limited approaches. It will also provide significant noise reduction.
Computational Improvements for Optical Coherence Tomography Dr. Boppart from the University of Illinois has developed new computational algorithms to improve Optical Coherence Tomography (OCT) imaging. This will provide... Read More Dr. Boppart from the University of Illinois has developed new computational algorithms to improve Optical Coherence Tomography (OCT) imaging. This will provide surgeons with a better view of cancerous tissue and allow improved treatment of numerous diseases.
EMCCD Scintillation Camera for Low Energy X and Gamma Ray Imaging A system that incorporates teachings of the present disclosure may include, for example, an ionizing radiation sensor having a first scintillator for generating... Read More A system that incorporates teachings of the present disclosure may include, for example, an ionizing radiation sensor having a first scintillator for generating photons from incoming ionizing radiation, an imaging intensifier for amplifying the photons, and an electron-multiplying charge-coupled device (EMCCD) coupled to the imaging intensifier for sensing the amplified photons generated by the imaging intensifier.
A Non-Invasive Blood Viscosity Measurement through Pulse Oximetry A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation... Read More A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation level in a liquid, a magnetic source coupled to the pulse oximeter sensor, and a controller to control the pulse oximeter sensor and the magnetic source, and to measure a mechanical effect on the liquid responsive to the magnetic source applying a magnetic field to the liquid.
Ultrasonic Biopsy Needle Shear Wave Imaging An apparatus and method for estimating and imaging mechanical properties of biological tissues. The apparatus includes one or two ultrasound emitting devices (... Read More An apparatus and method for estimating and imaging mechanical properties of biological tissues. The apparatus includes one or two ultrasound emitting devices (transducers) that first apply an acoustic radiation force to vibrationally displace a sphere embedded in the medium. Alternatively, a biopsy needle may be inserted into the medium and vibrated along its axis to generate shear waves. During and after vibration, ultrasound is again applied to image shear waves in the medium that propogate from the vibrating sphere or needle. By measuring the local wavelength of the shear waves, the shear modulus and viscous coefficient of the medium surrounding the vibrating element are estimated.
Computed Pathology: Stain-Free Computational Imaging Researchers from the University of Illinois have developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological... Read More Researchers from the University of Illinois have developed a method of stain-free chemical imaging to highlight the morphology and molecular content of biological samples without the use of any stains or dyes. The tissue is computationally recreated as if it were stained and imaged in diagnosis of biological samples. This method improves the cost and efficiency by avoiding expense and lessening the time required to complete multiple stains. Also, it improves the overall consistency of the staining process.
Highly Accelerated Image Reconstruction in Medical Imaging Researchers from the University of Illinois have developed a state of the art method that can reconstruct images in better quality, in less time, with fewer scans... Read More Researchers from the University of Illinois have developed a state of the art method that can reconstruct images in better quality, in less time, with fewer scans. They leveraged sparse characteristic of the image data and produced a two step algorithm that learns the patches of the image from the data and subsequently decreases elements in each patch.

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