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A Handbook for Inventors and Innovators: Technology Transfer at the University of Illinois

An introduction to the University’s intellectual property policies, patenting and commercialization services, intellectual property fundamentals, and most importantly, to your role in the process of commercializing University innovations. Learn more.

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Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 
G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation.
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Starfire Industries

Develops advanced plasma technologies with application to space propulsion, nuclear fusion, and industrial processing.

Mimosa Acoustics

Manufactures and distributes a portable Otoacoustic Emission System that is FDA-approved for testing the inner-ear function of infants, but can also be used in hearing screening research.

Distant Focus Corporation

Distant Focus provides innovative solutions to a variety of research and development communities, specializing in optical systems, computer automation, specialty optical sensors and sensor networks, and distributed processing environments. Founded by UI professor David Brady.

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