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A Handbook for Inventors and Innovators: Technology Transfer at the University of Illinois

An introduction to the University’s intellectual property policies, patenting and commercialization services, intellectual property fundamentals, and most importantly, to your role in the process of commercializing University innovations. Learn more.

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Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 
G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation.
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Dioxide Materials Inc.

Dioxide Materials develops and licenses new technology for CO2 remediation. This includes technology to reduce the amount of CO2 that is produced, and technology to create uses for any CO2 that is formed. The company is focused on devices that reduce the carbon footprint of homes and businesses and processes that convert waste CO2 into useful fuels and chemicals. The company aims to make homes and businesses safer and more energy efficient and to reduce the carbon footprint of US industry. Founded by Dr.

HDF Group

Open source data management solutions for large amounts of scientific data, maintain and program Heirarchal Data Format (HDF). Spin out from NCSA.

WebScalers

WebScalers provides solutions to various business problems associated with online search coverage, quality and effectiveness. The WebScaler’s technology is based upon several years of collaborative research and development between universities and the company and is funded by the National Science Foundation. Deliver in time-sensitive and location-specific information from surface and deep Web, the technology platform can be used to build various industry-specific vertical applications.

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