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A Handbook for Inventors and Innovators: Technology Transfer at the University of Illinois

An introduction to the University’s intellectual property policies, patenting and commercialization services, intellectual property fundamentals, and most importantly, to your role in the process of commercializing University innovations. Learn more.

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In stroke research, the hippocampal acute brain slice preparation is a model for studying how neuronal tissue responds to a hypoxic insult. Additionally, in diabetes research, pancreatic islets preparation and dynamic loading of oxygen and glucose is critical to understand how hypoxia alters the glucose-insulin response of the pancreas. However, standard techniques using commercial perfusion chambers cannot accurately provide oxygen delivery and control to model hypoxic conditions.
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 
G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation.
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CASI, Computational Applications and System Integration, Inc.

Development and licensing of mission-critical solvers for solutions of linear systems.

Common Ground Publishing

Common Ground is a producer and manager of content for print and the internet. The company works in four areas: conferences, publishing, research, and software.

Numentek America, Inc.

Numentek America Incorporation is a high technology venture company established by Numentek Co., Ltd in South Korea for manufacturing state-of-the-art lasers and optical instruments targeting biomedical and bioengineering applicaitons .

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