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A Handbook for Inventors and Innovators: Technology Transfer at the University of Illinois

An introduction to the University’s intellectual property policies, patenting and commercialization services, intellectual property fundamentals, and most importantly, to your role in the process of commercializing University innovations. Learn more.

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Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Epigenetic regulation and subsequent gene expression or silencing represents a tightly orchestrated interplay among enzymes responsible for modifying the tails of histones, around which nuclear DNA is wrapped.
Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation.  Dysregulation of histone acetylation, involving CBP, a neuroprotective transcription factor with histone acetyltransferase activity, has been found in Huntington’s disease (HD), Alzheimer’s disease (AD), and Rubinstein-Taybi syndrome. In a cellular model of AD, cell death was accompanied by loss of CBP function and histone deacetylation. 
G9a is overexpressed in various human cancer including leukemia, prostate cancer, hepatocellular carcinoma and lung cancer. Inhibitors of G9a are candidates for cancer treatment. A new family of G9A inhibitors have been recently identified and characterized. Through the characterization of these inhibitors, insight has been gained on the mechanistic contribution of G9a in the deregulation of the cell cycle in cancer and methyltransferase G9a regulation of a crucial step in cellular degradation.
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IllinoisRocstar LLC

IllinoisRocstar performs computational analyses for U.S. government agencies and industries, employing first-principles based physics for high-fidelity numerical analysis of fluid flows, combustion, materials, structures, and their interactions in complex changing geometries.

Autonomic Materials Incorporated

AMI is developing self-healing technologies that extend the lifetime of coatings. The technologies can be used in elastomer coatings, thermosetting coatings, and powder coatings, making them useful across a wide range of markets, from marine to aerospace.

Jangee Venture, Ltd

Jangee is a peer-to-peer social lending platform, enabling individuals to acquire unsecured loans at competitive rates without going through traditional financial institutions such as banks and credit unions.

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